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Cited by 97Diabetes Management and ResearchDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Effect of meal frequency on blood glucose, insulin, and free fatty acids in NIDDM subjects

Bertelsen, Jette, Christiansen, Christian, Thomsen, Claus, Poulsen, Per L, Vestergaard, Svend, Steinov, Alice, Rasmussen, Lars H, Rasmussen, Ole +1 more·1993·Diabetes Care
DOI 10.2337/diacare.16.1.4
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Abstract

OBJECTIVE: We studied the effects of meal frequency on blood glucose, serum insulin, and FFAs in 12 NIDDM subjects. RESEARCH DESIGN AND METHODS: Subjects were assigned in random order to two 8-hr observation periods after an overnight fast. They received isocaloric diets with similar composition either as six small or as two large meals. At the end of each study period, an IVGTT was given. RESULTS: Two large meals induced an 84% greater maximum amplitude of glucose excursions than six small meals (6.1 +/- 0.5 vs. 3.3 +/- 0.5 mM, P < 0.005) and higher insulin responses (P < 0.03). The Kg response to an IVGTT did not differ in the two situations. The average FFA level was lowest in response to frequent meals (P < 0.02). CONCLUSIONS: A higher meal frequency acutely subdues glucose excursions and reduces insulin and FFA levels during the daytime in older NIDDM subjects.

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Crossref · 10.2337/diacare.16.1.4

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  • Clinical trials, both short-term and long-term, with or without caloric restriction, in various populations, have produced contradictory results regarding the association of meal frequency with body weight, postprandial glycemia, insulin resistance, and overall glycemic control.

    “Clinical trials, both short-term (14–28 days) [321,325,328,329,330,331,332] and long-term [323,324] with no caloric restriction in non-obese and obese women with PCO syndrome at an early or late stage IGT or overt early-stage T2DM, and long-term studies with caloric restriction in T2DM without [333] or with antidiabetic treatment [320,326], have produced contradictory results regarding the associ”

    From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [330]

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Authors
Bertelsen, J., Christiansen, C., Thomsen, C., Poulsen, P. L., Vestergaard, S., Steinov, A., Rasmussen, L. H., Rasmussen, O., & Hermansen, K.
Affiliations
Aarhus Municipality (DK)
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
1993-01-01
Volume
16
Issue
1
Pages
4-7
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.16.1.4
OpenAlex
W1964898528
Cited by
97
References
14
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 9 · 2014: 1 · 2013: 8
FWCI
2.11
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
meal frequency, type 2 diabetes, blood glucose, insulin response, free fatty acids, glycemic excursions, isocaloric diet, glucose tolerance, older adults
MeSH terms
Blood Glucose, Diabetes Mellitus, Type 2, Eating, Fatty Acids, Nonesterified, Female, Glycosuria, Humans, Insulin, Male, Middle Aged, Time Factors

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