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Cited by 97Diabetes and associated disordersDiabetes Management and ResearchGenetic Associations and Epidemiology

Epidemiology, clinical aspects, and biology of IDDM patients under age 40 years. Comparison of data from Antwerp with complete ascertainment with data from Belgium with 40% ascertainment. The Belgian Diabetes Registry

Vandewalle, Christina L, Coeckelberghs, Marina I, De Leeuw, Ivo H, Caju, Marc V Du, Schuit, Frans C, Pipeleers, Daniel G, Gorus, Frans K·1997·Diabetes Care
DOI 10.2337/diacare.20.10.1556
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Abstract

OBJECTIVE: To compare the incidence rate of IDDM in the age-groups 0–14 and 15–39 years in Antwerp, Belgium, and to compare demographic, clinical, and biological data from Antwerp IDDM patients with 92% ascertainment with those from a larger Belgian patient group with 40% ascertainment. RESEARCH DESIGN AND METHODS: Incident cases of IDDM were reported by physicians of the Belgian Diabetes Registry and in Antwerp by several other sources. In Antwerp, completeness of ascertainment was calculated by the capture-recapture method. Demographic and clinical data were collected by questionnaire. Blood was sampled for HLA-DQ genotyping and, in new-inset patients, for autoantibodies. RESULTS: In Antwerp, the age- and sex-standardized IDDM incidence rates were similar in both age-groups (0–14 years: 11.8/100,000; 15–39 years: 8.9/100,000). The incidence rate decreased in girls above age 15 years (6.9/100,000; P = 0.003) but not in boys (11.0/100,000). Both in Antwerp and Belgium, IDDM was diagnosed more frequently in the 15–39 years age-group (60% of all cases) than under age 15 years, with a lower prevalence of acute symptoms, ketonuria, high-risk HLA-DQ genotype, and autoantibodies against insulin, islet cells, and IA-2, but with a higher prevalence of GAD65 autoantibodies. CONCLUSIONS: In Antwerp, the incidence rate of IDDM under age 15 years is intermediately high compared with the rates in other European regions. It is similar in the 15–39 years age-group, but with a marked male predominance. Demographic, clinical, and biological data show the same age-dependent heterogeneity as the data collected nationwide, with 40% ascertainment indicating the representativeness of the latter.

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Crossref · 10.2337/diacare.20.10.1556

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  • Type 1 diabetes is the major diabetes type in youth, accounting for at least 85% of all diabetes cases in youth under 20 years worldwide.

    “T1D is the major type of diabetes in youth, accounting for ≥85% of all diabetes cases in youth < 20 years of age worldwide 2,21,22.”

    From Epidemiology of type 1 diabetes (2010) · cites this paper as [21]

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Authors
Vandewalle, C. L., Coeckelberghs, M. I., De Leeuw, I. H., Caju, M. V. D., Schuit, F. C., Pipeleers, D. G., & Gorus, F. K.
Affiliations
  • Vrije Universiteit Brussel (BE)
  • Algemeen Kinderziekenhuis Departments of Endocrinology, Vrije Universiteit Brussel Belgian Diabetes Registry, Brussels, Belgium
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
1997-10-01
Volume
20
Issue
10
Pages
1556-1561
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.20.10.1556
OpenAlex
W2047647457
Cited by
97
References
0
Citations by year
2025: 1 · 2022: 2 · 2021: 18 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 3
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fonds Wetenschappelijk Onderzoek
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
type 1 diabetes, type 1 diabetes incidence, children and adolescents, autoantibodies, GAD65 antibodies, islet autoantibodies, IA-2 autoantibodies, insulin autoantibodies, ketonuria, Antwerp
MeSH terms
Adolescent, Adult, Age Factors, Autoantibodies, Belgium, Child, Child, Preschool, Demography, Diabetes Mellitus, Type 1, Female, Genotype, HLA-DQ Antigens, Humans, Infant, Insulin Antibodies, Male, Surveys and Questionnaires, Registries, Sex Factors, Urban Population, Reproducibility of Results, Incidence, HLA-DQ alpha-Chains, HLA-DQ beta-Chains

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