The Incidence of Type 1 Diabetes in the Age Group 0–39 Years Has Not Increased in Antwerp (Belgium) Between 1989 and 2000
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OBJECTIVE—A worldwide increase in the incidence of childhood type 1 diabetes has been observed. Because in various countries the majority of new type 1 diabetic patients are diagnosed in adulthood, we investigated whether the rising incidence of this disorder in children reflects a global increase in the incidence of diabetes or a shift toward earlier clinical presentation. RESEARCH DESIGN AND METHODS—The incidence of type 1 diabetes presenting before age 40 years was prospectively measured in the Antwerp district over a 12-year period (1989–2000). The completeness of ascertainment was evaluated by the capture-recapture method. Trends in incidence during the study period were analyzed by Poisson regression. RESULTS—The incidence of type 1 diabetes diagnosed before age 40 years remained constant over the 12-year period, averaging 9.9 cases per 100,000 individuals per year. The incidence was similar in both sexes under age 15 years, but a marked male excess was noted for adult-onset disease, in particular after age 20 years, resulting in a male-to-female ratio of 0.9 under age 15 years vs. 1.6 thereafter (P = 0.001). During the 12-year observation period, there was a significant tendency toward increasing incidence under age 15 years at the expense of a decreasing incidence between ages 15 and 40 years (P = 0.025). The annual increase in incidence averaged 1.8% under age 15 years and 5.0% under age 5 years (P = 0.06). CONCLUSIONS—Our results indicate that in Belgium, the increasing incidence of childhood type 1 diabetes—especially for children under age 5 years—is not attributable to a global increase in disease incidence, but rather to earlier clinical manifestation. The results suggest that an environmental factor may preferentially accelerate the subclinical disease process in young diabetes-prone subjects.
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Many reports indicate an excess of type 1 diabetes cases in male adults after the pubertal years, with a male-to-female ratio of at least 1.5, in populations of European origin.
“Many reports indicate an excess of T1D cases in male adults after the pubertal years (male-female ratio ≥1.5) in populations of European origin 31–34.”
From Epidemiology of type 1 diabetes (2010) · cites this paper as [32]
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Islet/pancreas transplantation: challenges for pediatrics
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Incidencia de la diabetes mellitus tipo 1 en Asturias entre 2011 y 2020
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Incidence of type 1 diabetes mellitus in Navarre stabilized in the last eight years
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- Authors
- Weets, I., De Leeuw, I. H., Du Caju, M. V. L., Rooman, R., Keymeulen, B., Mathieu, C., Rottiers, R., Daubresse, J.-C., Rocour-Brumioul, D., Pipeleers, D. G., Gorus, F. K., & The Belgian Diabetes Registry
- Affiliations
- Diabetes Research Center, Free University, Brussels, Belgium
- Departments of Endocrinology and Pediatrics, University of Antwerp, Antwerp, Belgium
- University of Antwerp (BE)
- KU Leuven (BE)
- Ghent University (BE)
- Hôpital Civil de Charleroi (BE)
- Centre hospitalier régional de la Citadelle (BE)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2002-05-01
- Volume
- 25
- Issue
- 5
- Pages
- 840-846
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2152560869
- Cited by
- 137
- References
- 34
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 5 · 2016: 7 · 2015: 6 · 2014: 14 · 2013: 8 · 2012: 4
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- Queen's University
- Novo Nordisk
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 1 diabetes, incidence trends, pediatric diabetes, adult-onset type 1 diabetes, age of onset, sex differences, mark-recapture, environmental risk factors, Antwerp
- MeSH terms
- Adolescent, Adult, Belgium, Child, Child, Preschool, Diabetes Mellitus, Type 1, Female, Humans, Infant, Infant, Newborn, Male, Regression Analysis, Time Factors, Incidence, Age Distribution, Sex Distribution
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