The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cognitive Function in an Elderly Population With Persistent Impaired Glucose Tolerance
Abstract
OBJECTIVE: To study cognitive function in an elderly population with persistent impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS: Fasting and postload 2-h plasma glucose and insulin levels were determined at baseline in a population-based sample of 1,300 people and repeated an average of 3.5 years later in 980 subjects. At follow-up, cognitive function was evaluated in subjects with persistent normal glucose tolerance (NGT; n = 506) and IGT (n = 80) with a brief neuropsychological test battery. RESULTS: Subjects with persistent IGT scored lower in the Mini-Mental State Examination (MMSE) and in the Buschke Selective Reminding Test long-term memory scores. Multiple linear regression analysis revealed that age, education, and insulin levels (either fasting or 2-h value) were associated with the MMSE score in subjects with persistent IGT. Other potential risk factors for impaired cognitive function were not significantly associated with the MMSE score. CONCLUSIONS: Our study showed that persistent IGT in the elderly is associated with mildly impaired cognitive function, and hyperinsulinemia may account for this association.
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Cites
Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
Modan, M., Halkin, H., Almog, S., Lusky, A., Eshkol, A., Shefi, M., Shitrit, A., & Fuchs, Z. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111776 · Cited by 1,465
Impaired Glucose Tolerance as a Disorder of Insulin Action
Lillioja, S., Mott, D. M., Howard, B. V., Bennett, P. H., Yki-Järvinen, H., Freymond, D., Nyomba, B. L., Zurlo, F., Swinburn, B., & Bogardus, C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805123181901 · Cited by 578
Strachan, M. W. J., Deary, I. J., Ewing, F. M. E., & Frier, B. M. (1997) · Diabetes Care · doi:10.2337/diacare.20.3.438 · Cited by 529 · cited 1×
“I mpaired cognitive function has been frequently reported in NIDDM (1), but milder abnormalities in glucose metabolism, i.”
BackgroundEffect of insulin on central catecholamines
Sauter, A., Goldstein, M., Engel, J., & Ueta, K. (1983) · Brain Research · doi:10.1016/0006-8993(83)90691-1 · Cited by 181 · cited 1×
“Insulin has been shown to reduce cholinergic activity in cultured striatal neurons (33) and to accelerate the turnover of monoamines in the brain (34,35).”
BackgroundVanhanen, M., Koivisto, K., Karjalainen, L., Helkala, E.-L., Laakso, M., Soininen, H., & Riekkinen, P. (1997) · NeuroReport · doi:10.1097/00001756-199704140-00041 · Cited by 77
Self-citation
Cited by
Insulin and neurodegenerative disease: shared and specific mechanisms
Craft, S., & Stennis Watson, G. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00681-7 · Cited by 830
Cognitive Dysfunction and Diabetes Mellitus
Kodl, C. T., & Seaquist, E. R. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0034 · Cited by 802
Smith, E., Hay, P., Campbell, L., & Trollor, J. N. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00920.x · Cited by 707
Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
Kanoski, S. E., & Davidson, T. L. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.003 · Cited by 676
The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function
Awad, N., Gagnon, M., & Messier, C. (2004) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390490514875 · Cited by 551
Metadata
- Authors
- Vanhanen, M., Koivisto, K., Kuusisto, J., Mykkänen, L., Helkala, E.-L., Hänninen, T., Riekkinen, P., Soininen, H., & Laakso, M.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1998-03-01
- Volume
- 21
- Issue
- 3
- Pages
- 398-402
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2171754797
- Cited by
- 187
- References
- 5
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vanhanen, M., Koivisto, K., Kuusisto, J., Mykkänen, L., Helkala, E.-L., Hänninen, T., Riekkinen, P., Soininen, H., & Laakso, M. (1998). Cognitive Function in an Elderly Population With Persistent Impaired Glucose Tolerance. Diabetes Care. https://doi.org/10.2337/diacare.21.3.398
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