The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Impaired Autonomic Function Is Associated With Increased Mortality, Especially in Subjects With Diabetes, Hypertension, or a History of Cardiovascular Disease
Open accessAbstract
OBJECTIVE: Measures of baroreflex sensitivity, heart rate variability (HRV), and the classical Ewing test parameters are currently used for the diagnosis of diabetic autonomic neuropathy and for mortality risk stratification after myocardial infarction. However, the strengths of the associations of these measures of autonomic function with risk of mortality have never been compared in one study population. Furthermore, no evidence is available on the possible effect of glucose tolerance on these associations. RESEARCH DESIGN AND METHODS: The study population (n = 605) consisted of a glucose tolerance-stratified sample from a general population (50-75 years of age). Cardiac cycle duration and continuous finger arterial pressure were measured under two conditions: at rest and on metronome breathing. From these readings, seven parameters of autonomic function were assessed (one Ewing, five HRV, and one baroreflex sensitivity). RESULTS: During 9 years of follow-up, 101 individuals died, 43 from cardiovascular causes. Subjects with diabetes and low levels of the autonomic function parameters, indicating impaired autonomic function, had an approximately doubled risk of mortality. This association was consistent, though not statistically significant, for all parameters. The elevated risk was not observed in subjects without diabetes, hypertension, or prevalent cardiovascular disease. CONCLUSIONS: Impaired autonomic function is associated with all-cause and cardiovascular mortality. Moreover, the results of the present study suggest that cardiac autonomic dysfunction in patients already at risk (diabetes, hypertension, or history of cardiovascular disease) may be especially hazardous.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, despite HRV being linked with the severity of T2DM [23], no studies have comprehensively assessed the role of the most common variables, such as age [24], gender [25], blood glucose control [26], or medications treating for T2DM, on HRV parameters [27,28].”
From Heart rate variability in type 2 diabetes mellitus: A systematic review and meta–analysis (2018) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289
Rovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120
Frequency domain measures of heart period variability and mortality after myocardial infarction
Bigger, J. T., Fleiss, J. L., Steinman, R. C., Rolnitzky, L. M., Kleiger, R. E., & Rottman, J. N. (1992) · Circulation · doi:10.1161/01.cir.85.1.164 · Cited by 1,712
The Value of Cardiovascular Autonomic Function Tests: 10 Years Experience in Diabetes
Ewing, D. J., Martyn, C., Young, R. J., & Clarke, B. F. (1985) · Diabetes Care · doi:10.2337/diacare.8.5.491 · Cited by 1,436
Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study
Tsuji, H., Venditti, F. J., Manders, E. S., Evans, J. C., Larson, M. G., Feldman, C. L., & Levy, D. (1994) · Circulation · doi:10.1161/01.cir.90.2.878 · Cited by 1,114
Fifteen years experience with finger arterial pressure monitoring: assessment of the technology
Imholz, B. P. M. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00067-4 · Cited by 841
de Vegt, F., Dekker, J. M., Ruhé, H. G., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., & Heine, R. J. (1999) · Diabetologia · doi:10.1007/s001250051249 · Cited by 611
Balkau, B., Shipley, M. J., Jarrett, R. J., Pyörälà, K., Pyörälä, M., Forhan, A., & Eschwège, É. (1998) · Diabetes Care · doi:10.2337/diacare.21.3.360 · Cited by 597
Dekker, J. M., Schouten, E. G., Klootwijk, P., Pool, J., Swenne, C. A., & Kromhout, D. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009049 · Cited by 519
Research works printed but not linked: 2
- Tenvoorde BJ, Faes ThJC, Janssen TWJ, Scheffer GJ, Rompelman O: Respiratory modulation of blood pressure and heart rate studied with a computer model of baroreflex control. In Computer Analysis of Cardiovascular Signals. Di Rienzo M, Mancia G, Parati G, Pedotti A, Zanchetti A, Eds. Washington, DC, IOS Press, 1995, p. 119–134
- World Health Organization: International Classification of Diseases. Vol. 1–2, 9th ed. Geneva, World Health Organization, 1977
Cited by
Sorted by citations
Items 101–200 of 455
Autonomic Peripheral Neuropathy
Freeman, R. L. (2007) · Neurologic Clinics · doi:10.1016/j.ncl.2007.01.001 · Cited by 51
Sangaleti, C. T., Katayama, K. Y., Angelis, K. D., de Moraes, T. L., de Araújo, A. A., Lopes, H. F., Camacho, C. P., Bortolotto, L. A., Michelini, L. C., Irigoyen, M. C., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.613979 · Cited by 50
“morbidity and mortality in MetS, and cardiovascular disease (6, 8, 12).”
BackgroundNishimura, M., Hashimoto, T., Kobayashi, H., Fukuda, T., Okino, K., Yamamoto, N., Nakamura, N., Yoshikawa, T., Takahashi, H., & Ono, T. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh361 · Cited by 49
“Coexistence of cardiovascular autonomic neuropathy and LVH, both of which are independent risk factors for major cardiac events such as myocardial infarction or congestive heart failure [1,3–5], is likely to be one of the key factors for poor prognosis in diabetic ESRD Autonomic neuropathy and LVH in diabetic ESRD 2537”
BackgroundScholte, A. J. H. A., Schuijf, J. D., Delgado, V., Kok, J. A., Bus, M. T. J., Maan, A. C., Stokkel, M. P. M., Kharagitsingh, A. V., Dibbets‐Schneider, P., van der Wall, E. E., et al. (2010) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-010-1442-0 · Cited by 49
“Furthermore, CAN is one of the most common complications associated with diabetes and has been associated with an increased risk of mortality and major cardiovascular events [4].”
BackgroundResultLiu, A., Ma, X., Shen, F., Liu, J., Chen, H., & Su, D. (2007) · Stroke · doi:10.1161/strokeaha.106.480061 · Cited by 49
Kaikkonen, K., Korpelainen, R., Tulppo, M. P., Kaikkonen, H., Vanhala, M., Kallio, M., Keinanen-Kiukaanniemi, S. M., & Korpelainen, J. T. (2014) · Journal of Physical Activity and Health · doi:10.1123/jpah.2012-0405 · Cited by 48
Fakhrzadeh, H., Yaminisharif, A., Sharifi, F., Tajalizadekhoob, Y., Mirarefin, M., Mohammadzadeh, M., Sadeghian, S., Badamchizadeh, Z., & Larijani, B. A. (2012) · ISRN Endocrinology · doi:10.5402/2012/168264 · Cited by 50
“In the Hoorn Town of The Netherlands HF, and LF powers and SDNN were lower among T2DM participants compared to those with normal fasting glucose [25].”
BackgroundCohort Profile: The Hoorn Studies
Rutters, F., Nijpels, G., Elders, P. J. M., Stehouwer, C. D. A., van der Heijden, A. A. W. A., Groeneveld, L., Hart, L. M. ‘., Dekker, J. M., & Beulens, J. W. J. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyx227 · Cited by 46
Howorka, K., Pumprla, J., Tamm, J., Schabmann, A., Klomfar, S., Kostineak, E., Howorka, N., & Sovová, E. (2013) · Autonomic Neuroscience · doi:10.1016/j.autneu.2013.08.065 · Cited by 44
“Diabetic autonomic neuropathy is related to an increased all-cause mortality risk in diabetic patients (Ewing et al., 1985; Ziegler et al., 1992; Vinik and Erbas, 2001; Gerritsen et al., 2001; Wheeler et al., 2002).”
BackgroundJung, C., Kim, B., Kim, C., Kang, S., Jung, S.-H., & Mok, J. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-24 · Cited by 45
Resistant Hypertension: Mechanisms and Treatment
Hwang, A. Y., Dietrich, E. A., Pepine, C. J., & Smith, S. M. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0754-x · Cited by 47
Koivikko, M. L., Tulppo, M. P., Kiviniemi, A. M., Kallio, M., Perkiömäki, J. S., Salmela, P. I., Airaksinen, J. K. E., & Huikuri, H. V. (2012) · Diabetes Care · doi:10.2337/dc11-2120 · Cited by 46
“A dysfunction of autonomic nervous system has been associated with increased mortality after myocardial infarction (13,14) in patients with diabetes (15,16) and in the general population (17).”
BackgroundCardiovascular autonomic neuropathy: Diagnosis and management
Vinik, A. I., & Erbas, T. A. (2006) · Current Diabetes Reports · doi:10.1007/s11892-006-0074-z · Cited by 44
“In addition, the investigators suggested that cardiovascular autonomic dysfunction in individuals already at high risk (eg, those with diabetes, high blood pressure, or a history of cardiovascular disease) may be particularly hazardous [ 30 ].”
BackgroundPowell, L., Guastella, A. J., McGreevy, P., Bauman, A., Edwards, K. M., & Stamatakis, E. (2019) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2018.10.008 · Cited by 63
Measurement fidelity of heart rate variability signal processing: The devil is in the details
Jarrin, D. C., McGrath, J. J., Giovanniello, S., Poirier, P., & Lambert, M. A. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.07.004 · Cited by 50
“…2002), irritable bowel syndrome, anorexia nervosa (Mazurak et al., 2011), epilepsy (Ferri et al., 2002), anxiety (Friedman, 2007; Friedman and Thayer, 1998), and major depressive disorder (Nugent et al., 2011), as well as mortality (Camm et al., 2001; Gerritsen et al., 2001; Thayer and Lane, 2007).”
BackgroundBaroreflex sensitivity and outcomes following coronary surgery
Ranucci, M., Porta, A., Bari, V., Pistuddi, V., & Rovere, M. T. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175008 · Cited by 41
Gimelli, A., Liga, R., Agostini, D., Bengel, F. M., Ernst, S., Hyafil, F., Saraste, A., Scholte, A. J. H. A., Verberne, H. J., Verschure, D. O., et al. (2021) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeab007 · Cited by 42
“cardial ischaemia, ultimately leading to increased arrhythmia susceptibility.(75,76) CAN has been classically demonstrated non-invasively by assessing heart rate variability (HRV) and baroreflex sensitivity.”
BackgroundPozza, R. D., Bechtold, S. M., Bonfig, W., Putzker, S., Kozlik-Feldmann, R. G., Schwarz, H., & Netz, H. (2007) · Diabetologia · doi:10.1007/s00125-007-0823-9 · Cited by 42
“Impairment of BRS has been shown to be a valuable predictor of future cardiovascular morbidity and mortality in a variety of diseases that are associated with disturbed autonomic function, such as myocardial infarction and diabetes mellitus [8, 9].”
BackgroundAldosterone, From (Patho)Physiology to Treatment in Cardiovascular and Renal Damage
Waanders, F., de Vries, L. V., van Goor, H., Hillebrands, J., Laverman, G. D., Bakker, S. J. L., & Navis, G. J. (2011) · Current Vascular Pharmacology · doi:10.2174/157016111796642689 · Cited by 41
“Aldosterone is a risk factor for decreased heart rate variability and prolonged QT interval, factors that predict sudden cardiac death [94-96].”
BackgroundSympathetic-leptin relationship in obesity: effect of weight loss
Quilliot, D., Böhme, P., Zannad, F. M., & Ziegler, O. (2008) · Metabolism · doi:10.1016/j.metabol.2007.11.020 · Cited by 41
Sacchetta, L., Chiriacò, M., Nesti, L., Leonetti, S., Forotti, G., Natali, A., Solini, A., & Tricò, D. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01675-6 · Cited by 41
Flynn, A. C., Jelinek, H. F., & Smith, M. (2005) · Australian Journal of Rural Health · doi:10.1111/j.1440-1854.2005.00658.x · Cited by 40
Beijers, H. J. B. H., Ferreira, I., Bravenboer, B., Dekker, J. M., Nijpels, G., Heine, R. J., & Stehouwer, C. D. A. (2009) · Diabetes Care · doi:10.2337/dc08-1544 · Cited by 40
“Table 3—Association of microalbuminuria or C-AD with cardiovascular and all-cause mortality Model* RR (95% CI)† Cardiovascular mortality All-cause mortality Microalbuminuria 1 3.49 (1.87–6.53) 2.12 (1.36–3.21) 2 2.23 (1.16–4.29) 1.46 (0.92–2.31) 3 2.09 (1.07–4.08) 1.32 (0.83–2.12) 4 2.13 (1.09–4.17) 1.33 (0.83–2.13) C…”
BackgroundMethodInfluentialBurger, A. J., D’Elia, J. A., Weinrauch, L. A., Lerman, I. G., & Gaur, A. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00346-7 · Cited by 40
Jung, C., Jung, S.-H., Kim, K.-J., Kim, B., Kim, C., Kang, S., & Mok, J. (2015) · Diabetes and Vascular Disease Research · doi:10.1177/1479164115588546 · Cited by 40
Cardiac Autonomic Function Correlates with Arterial Stiffness in the Early Stage of Type 1 Diabetes
Liatis, S., Αλεξιάδου, Κ., Tsiakou, A. G., Makrilakis, K., Katsilambros, Ν., & Tentolouris, N. (2011) · Experimental Diabetes Research · doi:10.1155/2011/957901 · Cited by 39
“Reduced cardiovascular autonomic function has been associated with increased total mortality and cardiovascular morbidity as well as mortality [17, 18].”
BackgroundLow, P. A. (2002) · Current Opinion in Neurology · doi:10.1097/00019052-200210000-00011 · Cited by 39
Autonomic Dysfunction in Diabetes: a Consequence of Cardiovascular Damage
Lefrandt, J. D., Smit, A. J., Zeebregts, C. J., Gans, R. O. B., & Hoogenberg, K. (2010) · Current Diabetes Reviews · doi:10.2174/157339910793499128 · Cited by 38
Cardoso, C. R. L., Leite, N. C., FREITAS, L., DIAS, S. B., Muxfeldt, E. S., & Salles, G. F. (2008) · Hypertension Research · doi:10.1291/hypres.31.865 · Cited by 38
“This increased mortality risk appears to be more marked in patients with diabetes, hypertension, or cardiovascular diseases (1).”
BackgroundGreen, K. T., Dennis, P. A., Neal, L. C., Hobkirk, A. L., Hicks, T. A., Watkins, L. L., Hayano, J., Sherwood, A., Calhoun, P. S., & Beckham, J. C. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.01.003 · Cited by 40
Alternative Quantitative Tools in the Assessment of Diabetic Peripheral and Autonomic Neuropathy
Vinik, A. I., CASELLINI, C. M., & Névoret, M. L. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.03.010 · Cited by 38
“Moreover, impaired autonomic function is associated with increased all-cause and cardiovascular mortality so that CAN in patients already at risk (diabetes, hypertension, or history of CVD) may be especially hazardous (Gerritsen et al., 2001).”
BackgroundJungen, C., Scherschel, K., Flenner, F., Jee, H., Rajendran, P. S., Jong, K. A. D., Nikolaev, V. O., Meyer, C. G., Ardell, J. L., & Tompkins, J. D. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00249.2019 · Cited by 38
Thiyagarajan, R., Subramani, S. K., Sampath, N., Trakroo, M., Pal, P., Bobby, Z., Paneerselvam, S., & Das, A. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041889 · Cited by 37
“74 participants were excluded from the study due to CVDs, chronic illness, primary autonomic failure, renal insufficiency or any history of medication intake that can affect CAF and FPG.”
BackgroundInfluentialBaroreceptor sensitivity and diabetes mellitus
Rowaiye, O. O., Jankowska, E. A., & Ponikowska, B. (2013) · Cardiology Journal · doi:10.5603/cj.2013.0130 · Cited by 36
“In the Hoorn study [80] involving hundreds of subjects who had either DM, or hypertension or a history of cardiovascular disease with a 9 year follow-up period, it was shown that the mortality risk from cardiac and other causes was roughly twice greater in those who had DM and concomitant impairment in autonomic funct…”
BackgroundDraghici, A. E., & Taylor, J. A. (2017) · Autonomic Neuroscience · doi:10.1016/j.autneu.2017.08.007 · Cited by 36
“(Grimm et al., 1998) reported lesser baroreflex sensitivity in individuals with low thoracic injuries whereas Houtman et al.”
Parati, G., & Carretta, R. (2006) · Journal of Hypertension · doi:10.1097/hjh.0b013e328012bf0f · Cited by 36
Korosoglou, G., Humpert, P. M., Halbgewachs, E., Bekeredjian, R., Filusch, A., Buss, S. J., Morcos, M., Bierhaus, A., Katus, H. A., Nawroth, P. P., et al. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.06.056 · Cited by 36
Determinants of autonomic dysfunction in idiopathic Parkinson’s disease
Korchounov, A., Kessler, K. R., Yakhno, N. N., Damulin, I. V., & Schipper, H. I. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0909-6 · Cited by 36
“Arterial hypertension has not been accounted for in previous studies on autonomic dysfunction in IPD, although it has been noted as one of several risk factors for erectile dysfunction [18], impaired heart rate variability [36] or cardiovascular reflexes [13].”
BackgroundSalles, G. F., Ribeiro, F. M., Guimarães, G. M., Muxfeldt, E. S., & Cardoso, C. R. L. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000068 · Cited by 34
“Reduced HRV was also demonstrated to predict worse cardiovascular prognosis not only in patients with coronary heart disease [6,7] and heart failure [8,9] but also in diabetic and hypertensive individuals [10,11] and in elderly population [12].”
BackgroundNeurovascular Function and Sudorimetry in Health and Disease
Vinik, A. I., Névoret, M. L., CASELLINI, C. M., & Parson, H. K. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0392-x · Cited by 37
“strongest predictor for mortality in diabetes mellitus, independently of baseline CV disease (CVD), diabetes duration , traditional CVD risk factors, and medications [70–72].”
BackgroundFrancica, J. V., Scapini, K. B., Bernardes, N., Spadari, J. A. A., Bigongiari, A., Mazuchi, F. D. A. E. S., Caperuto, É. C., Sanches, Í. C., Rodrigues, B., & Angelis, K. D. (2018) · Clinics · doi:10.6061/clinics/2018/e253 · Cited by 34
“Impaired baroreflex sensitivity has been found to be associated with an increased risk of cardiovascular events and mortality in several disorders, such as myocardial infarction (19,27), coronary surgery (28), heart failure (29), diabetes (30), and acute ischemic stroke (7).”
BackgroundRelationship between autonomic neuropathy and hypertension—are we underestimating the problem?
Istenes, I., Keresztes, K., Hermányi, Z., Putz, Z., Vargha, P., Gandhi, R. A., Tesfaye, S. H., & Kempler, P. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02458.x · Cited by 34
Dafaalla, M. D., Nimir, M., Mohammed, M. I., Ali, O., & Hussein, A. (2016) · Open Heart · doi:10.1136/openhrt-2015-000336 · Cited by 33
Influence of bariatric surgery on indices of cardiac autonomic control
Alam, I., Lewis, M. J., Lewis, K. E., Stephens, J. W., & BAXTER, J. N. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.08.007 · Cited by 32
“Notably, weight loss reverses obesity-related autonomic dysfunction, probably owing to increased cardiac vagal modulation, resulting in increased HRV and a reduction in heart rate (Tsuji et al., 1996; Gerritsen et al., 2001).”
BackgroundThe association between baroreflex sensitivity and blood pressure in children
Fitzgibbon‐Collins, L. K., Coverdale, N. S., Phillips, A. A., Shoemaker, J. K., Klentrou, P., Wade, T. J., Cairney, J., & O’Leary, D. D. (2012) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h11-163 · Cited by 32
Race Differences in Age-Trends of Autonomic Nervous System Functioning
Fuller‐Rowell, T. E., Williams, D. R., Love, G. D., McKinley, P. S., Sloan, R. P., & Ryff, C. D. (2013) · Journal of Aging and Health · doi:10.1177/0898264313491427 · Cited by 32
“Higher levels of HRV are associated with reduced risk of recurrent events in patients following myocardial infarction and with heart failure (Camm et al., 2004; Gerritsen et al., 2001; Kleiger, Miller, Bigger, & Moss, 1987) and with a lower likelihood of incident heart disease in initially healthy participants in comm…”
Whang, W., & Bigger, J. T. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00618-0 · Cited by 32
Sanya, E. O., Brown, C., Dütsch, M., Zikeli, U., Neundörfer, B., & Hilz, M. J. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01170.x · Cited by 32
Yang, H. P., Lopes, L. T., Barioni, N. O., Roeske, J., Incognito, A. V., Baker, J. R., Raj, S. R., & Wilson, R. J. A. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab334 · Cited by 32
Perugini, R. A., Li, Y., ROSENTHAL, L. S., Gallagher-Dorval, K. A., Kelly, J. J., & Czerniach, D. R. (2009) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2009.09.012 · Cited by 34
Baroreflex analysis in diabetes mellitus: linear and nonlinear approaches
Javorka, M., Lazarova, Z., Tonhajzerová, I., Turianiková, Z., Honzíková, N., Fišer, B., Javorka, K., & Baumert, M. (2010) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-010-0707-x · Cited by 31
“Survival analyses in diabetic subjects showed that impaired autonomic function was consistently associated with an approximately doubled risk of mortality [16].”
BackgroundHe, S., Yi-Ming, W., Xu, L., Miao, C., & Su, D. (2004) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2004.03988.x · Cited by 31
Eighteen Years of Fair Glycemic Control Preserves Cardiac Autonomic Function in Type 1 Diabetes
Larsen, J. R., Sjöholm, H., Berg, T. J., Sandvik, L., Brekke, M., Hanssen, K. F., & Dahl‐Jørgensen, K. (2004) · Diabetes Care · doi:10.2337/diacare.27.4.963 · Cited by 31
Hypoglycemia as a Driver of Cardiovascular Risk in Diabetes
Moheet, A. A., & Seaquist, E. R. (2013) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0351-7 · Cited by 30
(ESC), G. D. T. S. D. Y. E. C. D. L. S. E. D. C., & (EASD), D. L. S. E. P. E. E. D. L. D. (2007) · Revista Española de Cardiología · doi:10.1016/s0300-8932(07)75070-4 · Cited by 28
Heart rate variability is severely impaired among type 2 diabetic patients with hypertension
Istenes, I., Körei, A. E., Putz, Z., Németh, N., Martos, T., Keresztes, K., Kempler, M., Vági, O. E., Vargha, P., & Kempler, P. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2496 · Cited by 29
“This association was generally stronger in subjectswith diabetes, hypertension and a history of cardiovascular disease [29].”
BackgroundBari, V., Vaini, E., Pistuddi, V., Fantinato, A., Cairo, B., MARIA, B. D., Vecchia, L. A. D., Ranucci, M., & Porta, A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01319 · Cited by 29
Orthostatic hypertension and major adverse events: a systematic review and meta-analysis
Pasdar, Z., Paola, L. D., Carter, B., Pana, T. A., Potter, J. F., & Myint, P. K. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad158 · Cited by 29
Jung, C., Baek, A.-R., Kim, K.-J., Kim, B., Kim, C., Kang, S., & Mok, J. (2013) · Endocrinology and Metabolism · doi:10.3803/enm.2013.28.4.309 · Cited by 29
Santisteban, M. M., Zubcevic, J. A., Baekey, D. M., & Raizada, M. K. (2013) · Current Hypertension Reports · doi:10.1007/s11906-013-0361-4 · Cited by 31
Lee, S. J., Jeong, S. J., Lee, Y. C., Lee, Y. H., Lee, J. E., Kim, C. H., Min, K. W., & Cha, B. Y. (2017) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2017.41.4.275 · Cited by 30
Validity and Efficacy of the Elite HRV Smartphone Application during Slow-Paced Breathing
Vondrasek, J. D., Riemann, B. L., Grosicki, G. J., & Flatt, A. A. (2023) · Sensors · doi:10.3390/s23239496 · Cited by 39
Stuckey, M. I., Kiviniemi, A. M., & Petrella, R. J. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00121 · Cited by 32
Tiftikçioğlu, B. İ., Bilgin, Ş., Duksal, T., Köse, Ş., & Zorlu, Y. (2016) · Medicine · doi:10.1097/md.0000000000003340 · Cited by 28
“Loss of HRV was found to be an independent predictor of all-cause and cardiovascular mortality in population-based studies.(8,9) In patients with CAN, vagal impairment can lead to a relative predominance of sympathetic activity in the sympathovagal balance.”
BackgroundInterplay between baroreflex sensitivity, obesity and related cardiometabolic risk factors (Review)
Konstantinidou, S. M., Argyrakopoulou, G., Tentolouris, N., Karalis, V. D., & Kokkinos, A. D. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10990 · Cited by 31
“In addition, there is evidence that physical activity affects the autonomous nervous system and improves the condition of patients with autonomic disorders (72).”
BackgroundChesterton, L. J., & McIntyre, C. W. (2005) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000185981.02578.0e · Cited by 28
Urbančič‐Rovan, V., Meglič, B., Stefanovska, A., Bernjak, A., Ažman-Juvan, K., & Kocijancic, A. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02019.x · Cited by 28
Cardiac and pulmonary arterial remodeling after sinoaortic denervation in normotensive rats
Flues, K., Moraes-Silva, I. C., Mostarda, C. T., Souza, P. R. M., Diniz, G. P., Moreira, E. D., Piratello, A. C., de Chaves, M. L. M. B., Angelis, K. D., Salemi, V. M. C., et al. (2011) · Autonomic Neuroscience · doi:10.1016/j.autneu.2011.10.005 · Cited by 27
“Changes in baroreflex sensitivity and heart rate variability (HRV), the two main markers of autonomic nervous system activity, have been linked to an increased mortality rate, particularly in hypertensive subjects with a history of cardiovascular disease (La Rovere et al., 1998; Schwartz and La Rovere, 1998; Gerritsen…”
Chen, H., Lin, H.-D., Won, J. G. S., Lee, C.-H., Wu, S., Lin, J.-D., Juan, L.-Y., Ho, L., & Tang, K. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.08.012 · Cited by 27
“[3] J.”
BackgroundFu, Y.-J., He, S., Miao, C., Wang, M., & Su, D. (2004) · Journal of Hypertension · doi:10.1097/00004872-200406000-00018 · Cited by 27
Imaging of myocardial metabolism
Herrero, P., & Gropler, R. J. (2005) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2005.03.010 · Cited by 27
Vitamin D in the Spectrum of Prediabetes and Cardiovascular Autonomic Dysfunction
Dimova, R. B., Tankova, T. I., & Chakarova, N. Y. (2017) · Journal of Nutrition · doi:10.3945/jn.117.250209 · Cited by 27
Marital Status and Heart Rate Variability in Patients with Suspected Coronary Artery Disease
Randall, G., Bhattacharyya, M. R., & Steptoe, A. (2009) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9137-0 · Cited by 26
Kuncová, J., Švíglerová, J., Tonar, Z., & Slavı́ková, J. (2005) · Autonomic Neuroscience · doi:10.1016/j.autneu.2005.05.005 · Cited by 26
“Diabetes mellitus is frequently associated with cardiovascular autonomic neuropathy (CAN) that represents a serious complication of long-lasting diabetes and contributes significantly to the increased morbidity and mortality of diabetic patients (Ewing et al., 1991; Gerritsen et al., 2001).”
BackgroundZhang, W. J., Liu, A., Yi-Ming, W., Liu, J., Shen, F., & Su, D. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04746.x · Cited by 26
Clinical Implications of Baroreflex Sensitivity in Type 2 Diabetes
Sakamoto, M., Matsutani, D., & Kayama, Y. (2019) · International Heart Journal · doi:10.1536/ihj.18-455 · Cited by 25
Cardiovascular Autonomic Neuropathy Is Associated With Macrovascular Risk Factors in Type 2 Diabetes
Fleischer, J., Yderstræde, K. B., Gulichsen, E. H., Jakobsen, P. E., Lervang, H. H., Eldrup, E., Nygaard, H., Tarnow, L., & Ejskjær, N. (2014) · Journal of Diabetes Science and Technology · doi:10.1177/1932296814528616 · Cited by 24
“The Hoorn prospective study of glucose tolerance in a general population of Caucasian subjects (50-75 years of age) showed that autonomic dysfunction in patients already at risk (hypertension or history of cardiovascular disease) may be particularly hazardous.(30) From our results, obesity and smoking should also be a…”
BackgroundHuang, J., Kuo, I., Tsai, Y., Lee, J., Lim, L., Chen, S., Chiu, Y., Chang, J., & Chen, H.-H. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000469716 · Cited by 25
von Scholten, B. J., Hansen, C. S., Hasbak, P., Kjær, A., Rossing, P. R., & Hansen, T. W. (2016) · Diabetes · doi:10.2337/db16-0437 · Cited by 25
“CAN is strongly associated with cardiovascular morbidity and mortality (1,2).”
BackgroundBaroreflex sensitivity impairment during hypoglycemia: implications for cardiovascular control
Rao, A. D., Bonyhay, I., Dankwa, J., Baimas-George, M., Kneen, L., Ballatori, S., Freeman, R., & Adler, G. K. (2016) · Diabetes · doi:10.2337/db15-0871 · Cited by 25
“Baroreflex dysfunction is also associated with an increased risk of cardiac arrhythmias (29) and is a predictor of mortality in the period after a myocardial infarction (15) and in individuals with type 2 diabetes (13).”
BackgroundSoydan, N., Bretzel, R. G., Fischer, B., Wagenlehner, F., Pilatz, A. M. E., & Linn, T. (2013) · Metabolism · doi:10.1016/j.metabol.2012.12.003 · Cited by 26
Ren, L., Fang, X., Li-dong, R., Jian, G., Wang, Y., & Qi, G. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-104 · Cited by 24
Age‐related loss of cardiac vagal preganglionic neurones in spontaneously hypertensive rats
Corbett, E. K. A., Mary, D., McWilliam, P. N., & Batten, T. F. C. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2007.038216 · Cited by 24
Gasch, J., Reimann, M., Reichmann, H., Rüdiger, H., & Ziemssen, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018061 · Cited by 24
“In consequence baroreflex dysfunction has been associated with a worse outcome in diabetes mellitus [1] and after myocardial infarction [2].”
BackgroundLiu, A., Ling, G., Wu, J., Shen, F., Wang, D., Lin, L., Liu, J.-G., & Su, D. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.06.021 · Cited by 23
Stefano, C. D., Milazzo, V., Milan, A., Veglio, F., & Maule, S. V. (2016) · Liver International · doi:10.1111/liv.13126 · Cited by 23
“Several prospective studies have outlined the close correlation between increased mortality from cardiovascular causes and AD in diabetics (83).”
BackgroundAssociation between dysfunction of autonomic nervous system activity and mortality in schizophrenia
Hattori, S., Suda, A., Kishida, I., Miyauchi, M., Shiraishi, Y., Fujibayashi, M., Tsujita, N., Ishii, C., Ishii, N., Moritani, T., et al. (2018) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2018.08.002 · Cited by 23
Delirium in patients with hip fracture is associated with increased heart rate variability
Ernst, G., Watne, L. O., Rostrup, M., & Neerland, B. E. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01447-5 · Cited by 22
Bavanandan, S., Ajayi, S. O., Fentum, B., Paul, S. K., Carr, S., & Robinson, T. G. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00165.x · Cited by 22
Shen, F., Wang, J., Ni, C.-R., Yu, J., Wang, W.-Z., & Su, D. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04626.x · Cited by 22
Association of β-adrenoceptor polymorphisms with cardiac autonomic modulation in Japanese males
Matsunaga, T., Yasuda, K., Adachi, T., Gu, N., Yamamura, T., Moritani, T., Tsujimoto, G., & Tsuda, K. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.03.053 · Cited by 22
Decision trees and multi-level ensemble classifiers for neurological diagnostics
Jelinek, H. F., Abawajy, J., Kelarev, A. V., Chowdhury, M. U., & Stranieri, A. (2014) · AIMS Medical Science · doi:10.3934/medsci.2014.1.1 · Cited by 22
Syncope and orthostatic intolerance
Weimer, L. H., & Williams, O. A. (2003) · Medical Clinics of North America · doi:10.1016/s0025-7125(03)00007-5 · Cited by 22
Bravo, P. E., Hage, F. G., Woodham, R. M., Heo, J., & Iskandrian, A. E. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.06.021 · Cited by 22
Vági, O. E., Svébis, M. M., Domján, B. A., Körei, A. E., Istenes, I., Putz, Z., Mészáros, S., Hajdú, N., Békeffy, M. Z., Tesfaye, S. H., et al. (2021) · Journal of Diabetes Research · doi:10.1155/2021/6662159 · Cited by 24
Cardiovascular manifestations of neurologic disease
Dombrowski, K. E., & Laskowitz, D. T. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-7020-4086-3.00001-1 · Cited by 23
Wu, J., Lu, F., Yang, Y., Chang, S.-H., Huang, Y., Chen, J. J., & Chang, C. (2014) · Acta Diabetologica · doi:10.1007/s00592-013-0548-9 · Cited by 21
“sure, while impaired baroreflex sensitivity (BRS) is associated with adverse cardiovascular outcomes [1].”
BackgroundCardiovascular Autonomic Neuropathy
Stevens, M. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-311-0_24 · Cited by 21
Islet Transplantation as a Treatment for Diabetes
Harlan, D. M., & Rother, K. I. (2004) · New England Journal of Medicine · doi:10.1056/nejm200405133502022 · Cited by 21
Assessment of autonomic dysfunction in patients with type 2 diabetes using reactive hyperemia
Wu, H., Hsu, P.-C., Sun, C., Wang, H.-J., Liu, C.-C., Chen, H., Liu, A., Tang, C.-J., & Lo, M. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2013.03.022 · Cited by 20
Metadata
- Authors
- Gerritsen, J., Dekker, J. M., TenVoorde, B. J., Kostense, P. J., Heine, R. J., Bouter, L. M., Heethaar, R. M., & Stehouwer, C. D. A.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Department of Epidemiology and Biostatistics, Vrije Universiteit, Amsterdam, the Netherlands
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2001-10-01
- Volume
- 24
- Issue
- 10
- Pages
- 1793-1798
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2141929799
- Cited by
- 456
- References
- 27
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 14 · 2023: 15 · 2022: 14 · 2021: 20 · 2020: 17 · 2019: 17 · 2018: 17 · 2017: 17 · 2016: 22 · 2015: 24 · 2014: 21 · 2013: 32 · 2012: 29
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Diabetes Fonds
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- cardiovascular mortality, all-cause mortality, diabetic autonomic neuropathy, heart rate variability, baroreflex sensitivity, Ewing test, cardiac autonomic dysfunction, diabetes mellitus, hypertension, cardiovascular disease, glucose tolerance, risk stratification
- MeSH terms
- Aged, Autonomic Nervous System Diseases, Cardiovascular Diseases, Female, Heart Rate, Humans, Hypertension, Male, Middle Aged, Respiration, Risk Factors, Supination, Baroreflex, Diabetes Complications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
