Cited by 4,760Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk FactorsCardiovascular Health and Risk Factors

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Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome

Isomaa, Bo, Almgren, Peter, Tuomi, Tiinamaija, Forsén, Björn, Lahti, Kaj, Nissén, Michael, Taskinen, Marja-Riitta, Groop, Leif·2001·Diabetes Care

DOI 10.2337/diacare.24.4.683

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Abstract

OBJECTIVE—To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization (WHO). RESEARCH DESIGN AND METHODS—A total of 4,483 subjects aged 35–70 years participating in a large family study of type 2 diabetes in Finland and Sweden (the Botnia study) were included in the analysis of cardiovascular risk associated with the metabolic syndrome. In subjects who had type 2 diabetes (n = 1,697), impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) (n = 798), or insulin-resistance with normal glucose tolerance (NGT) (n = 1,988), the metabolic syndrome was defined as presence of at least two of the following risk factors: obesity, hypertension, dyslipidemia, or microalbuminuria. Cardiovascular mortality was assessed in 3,606 subjects with a median follow-up of 6.9 years. RESULTS—In women and men, respectively, the metabolic syndrome was seen in 10 and 15% of subjects with NGT, 42 and 64% of those with IFG/IGT, and 78 and 84% of those with type 2 diabetes. The risk for coronary heart disease and stroke was increased threefold in subjects with the syndrome (P < 0.001). Cardiovascular mortality was markedly increased in subjects with the metabolic syndrome (12.0 vs. 2.2%, P < 0.001). Of the individual components of the metabolic syndrome, microalbuminuria conferred the strongest risk of cardiovascular death (RR 2.80; P = 0.002). CONCLUSIONS—The WHO definition of the metabolic syndrome identifies subjects with increased cardiovascular morbidity and mortality and offers a tool for comparison of results from different studies.

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Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555
Cardiovascular Survey Methods.
Rose, G., & Blackburn, H. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-69-6-1335_2 · Cited by 3,090
Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents.
Tunstall-Pedoe, H., Kuulasmaa, K., Amouyel, P., Arveiler, D., Rajakangas, A.-M., & Pająk, A. (1994) · Circulation · doi:10.1161/01.cir.90.1.583 · Cited by 2,260
Comment on the provisional report from the WHO consultation
(1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00059.x · Cited by 1,820
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728
The Deadly Quartet
Kaplan, N. M. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.7.1514 · Cited by 1,672
Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
Modan, M., Halkin, H., Almog, S., Lusky, A., Eshkol, A., Shefi, M., Shitrit, A., & Fuchs, Z. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111776 · Cited by 1,465

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Show all 36 references

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Descovich GC, Benassi B, Cancelli V, D’Addato S, De Simone, Dormi A: An epidemic view of the plurimetabolic syndrome. In Diabetes, Obesity and Hyperlipidemias. V. The Plurimetabolic Syndrome Crepaleli G, Tiengo A, Manzato E, Eds. Amsterdam, Netherlands, Elsevier Science, 1993, p. 31–39
Bouchard C, Perusse L: Genetics of causes and manifestations of the metabolic syndrome. In Diabetes, obesity and hyperlipidemia: V. The plurimetabolic syndrome Crepaldi G, Tiengo A, Manzato E, Eds., Amsterdam, Elsevier Science, 1993, p. 67–74

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Bonora, E., Targher, G., Formentini, G., Calcaterra, F., Lombardi, S., Marini, F., Zenari, L., Saggiani, F., Poli, M., Perbellini, S., et al. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.01068.x · Cited by 287
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Weitzman, M. L., Cook, S. R., Auinger, P., Florin, T. A., Daniels, S. R., Nguyen, M., & Winickoff, J. P. (2005) · Circulation · doi:10.1161/circulationaha.104.520650 · Cited by 267
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Balkau, B., Vernay, M., Mhamdi, L., Novak, M., Arondel, D., Vol, S., Tichet, J., & Eschwège, É. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70067-8 · Cited by 268
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Hanley, A. J., Karter, A. J., Williams, K., Festa, A., Agostino, R. B. D., Wagenknecht, L. E., & Haffner, S. M. (2005) · Circulation · doi:10.1161/circulationaha.105.559633 · Cited by 267
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Caterson, I. D., Hubbard, V. S., Bray, G. A., Grunstein, R. R., HANSEN, B. C., Hong, Y., Labarthe, D. R., Seidell, J. C., & Smith, S. C. (2004) · Circulation · doi:10.1161/01.cir.0000140114.83145.59 · Cited by 264
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Boden-Albala, B. M., Sacco, R. L., Lee, H.-S., Grahame-Clarke, C. N., Rundek, T., Elkind, M. S. V., Wright, C. B., Giardina, E. V., Tullio, M. R. D., Homma, S., et al. (2007) · Stroke · doi:10.1161/strokeaha.107.496588 · Cited by 263
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Räikkönen, K., Matthews, K. A., & Kuller, L. H. (2002) · Metabolism · doi:10.1053/meta.2002.36301 · Cited by 315
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Deji, N., Kume, S., Araki, S., Soumura, M., Sugimoto, T., Isshiki, K., Chin‒Kanasaki, M., Sakaguchi, M., Koya, D., Haneda, M., et al. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00110.2008 · Cited by 263
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Mente, A., Yusuf, S., Islam, S., McQueen, M., Tanomsup, S., Onen, C. L., Rangarajan, S., Gerstein, H. C., & Anand, S. S. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.053 · Cited by 261
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Rosenson, R. S. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00239-9 · Cited by 264
Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes
Ferrannini, E., & DeFronzo, R. A. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv239 · Cited by 265
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Isomaa, B., Henricsson, M., Almgren, P.-E., Tuomi, T., Taskinen, M., & Groop, L. (2001) · Diabetologia · doi:10.1007/s001250100615 · Cited by 260
Self-citation
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Eckel, R. H., Barouch, W. W., & Ershow, A. G. (2002) · Circulation · doi:10.1161/01.cir.0000017823.53114.4c · Cited by 257
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Jericó, C. R., Knobel, H., Montero, M., Ordóñez‐Llanos, J., Guelar, A., Gimeno, J. L., Saballs, P., López-Colomés, J. L., & Pedro‐Botet, J. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.132 · Cited by 254
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Advances in edible oleogel technologies – A decade in review
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Warensjö, E., Öhrvall, M., & Vessby, B. O. (2005) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.06.001 · Cited by 260
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Noubiap, J. J., Nansseu, J. R., Lontchi‐Yimagou, E., Nkeck, J. R., Nyaga, U. F., Ngouo, A. T., Tounouga, D. N., Tianyi, F., Foka, A. J., Ndoadoumgue, A. L., et al. (2022) · LSTM Online Archive (Liverpool School of Tropical Medicine) · Cited by 254
The Prevalence of Metabolic Syndrome in Various Populations
Kolovou, G. D., Anagnostopoulou, K. K., Salpea, K. D., & Mikhailidis, D. P. (2007) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318065c3a1 · Cited by 255
Mortality in schizophrenia.
Auquier, P., Lançon, C., Rouillon, F., Lader, M., & Holmes, C. (2006) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1325 · Cited by 249
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Marroquin, O. C., Kip, K. E., Kelley, D. E., Johnson, B. D., Shaw, L. J., Bairey Merz, C. N., Sharaf, B. L., Pepine, C. J., Sopko, G., & Reis, S. E. (2004) · Circulation · doi:10.1161/01.cir.0000115517.26897.a7 · Cited by 243
Long-term follow-up of cardiovascular disease risk factors in children after an obesity intervention1,2
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A major health hazard: The metabolic syndrome
Isomaa, B. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00646-5 · Cited by 245
Self-citation
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Shimada, K., Miyazaki, T., & Daida, H. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.02.020 · Cited by 244
Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals
Harwood, H. J., Petras, S. F., Shelly, L. D., Zaccaro, L. M., Perry, D. A., Makowski, M. R., Hargrove, D. M., Martin, K. A., Tracey, W. R., Chapman, J. G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304481200 · Cited by 243
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Kondo, T., Kishi, M., Fushimi, T., UGAJIN, S., & Kaga, T. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90231 · Cited by 242
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Bertrais, S., Beyeme‐Ondoua, J., Czernichow, S., Galan, P., Herçberg, S., & Oppert, J. (2005) · Obesity Research · doi:10.1038/oby.2005.108 · Cited by 244
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Chen, B., Lam, K. S. L., Wang, Y., Wu, D., Lam, M. C., Shen, J., Wong, L., Hoo, R. L. C., Zhang, J., & Xu, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.004 · Cited by 238
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Ansari‐Moghaddam, A., Adineh, H. A., Zareban, I., Iranpour, S., Hosseinzadeh, A., & Kh, F. (2017) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2017.11.004 · Cited by 239
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Sherwin, R. S., Anderson, R. M., Buse, J. B., Chin, M. H., Eddy, D. M., FRADKIN, J. E., Ganiats, T. G., Ginsberg, H. N., Kahn, R., Nwankwo, R. B., et al. (2004) · Diabetes Care · doi:10.2337/diacare.27.2007.s47 · Cited by 244
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LIAO, Y., TAKASHIMA, S., MAEDA, N., OUCHI, N., KOMAMURA, K., SHIMOMURA, I., HORI, M., MATSUZAWA, Y., FUNAHASHI, T., & KITAKAZE, M. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.018 · Cited by 236
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Self-citation
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Boudreau, D. M., Malone, D. C., Raebel, M. A., Fishman, P. A., Nichols, G. A., Feldstein, A. C., Boscoe, A. N., Ben-Joseph, R. H., Magid, D. J., & Okamoto, L. J. (2009) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2008.0070 · Cited by 225
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Smith, G. N., WALKER, M. C., Liu, A., Wen, S. W., Swansburg, M. L., Ramshaw, H., White, R. R., Roddy, M., & Hladunewich, M. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.06.035 · Cited by 224
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He, Y., Jiang, B., Wang, J., Feng, K., Chang, Q., Fan, L., Li, X., & Hu, F. B. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.11.074 · Cited by 222
Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis
von Scheidt, M., Zhao, Y., Kurt, Z., Pan, C., Zeng, L., Yang, X., Schunkert, H., & Lusis, A. J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.11.001 · Cited by 230
Impairment of hepatic Stat-3 activation and reduction of PPARα activity in fructose-fed rats
Roglans, N., Vilà, L., Farré, M., Alegret, M., Sánchez, R. M., Vázquez‐Carrera, M., & Laguna, J. C. (2007) · Hepatology · doi:10.1002/hep.21499 · Cited by 226
Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register
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Zalesin, K. C., Franklin, B. A., Miller, W. M., Peterson, E. D., & McCullough, P. A. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.06.005 · Cited by 231
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Méndez‐Sánchez, N. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i11.1653 · Cited by 213
Cardiovascular metabolic syndrome – an interplay of, obesity, inflammation, diabetes and coronary heart disease
Rana, J. S., Nieuwdorp, M., Jukema, J. W., & Kastelein, J. J. P. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00594.x · Cited by 212
Time to abandon microalbuminuria?
Ruggenenti, P. L., & Remuzzi, G. (2006) · Kidney International · doi:10.1038/sj.ki.5001729 · Cited by 213
Sympathetic Neural Activation in Nondiabetic Metabolic Syndrome and Its Further Augmentation by Hypertension
Huggett, R. J., Burns, J., Mackintosh, A. F., & Mary, D. A. S. G. (2004) · Hypertension · doi:10.1161/01.hyp.0000147893.08533.d8 · Cited by 211
Pathophysiology of dyslipidaemia in the metabolic syndrome
Kolovou, G. D., Anagnostopoulou, K. K., & Cokkinos, D. V. (2005) · Postgraduate Medical Journal · doi:10.1136/pgmj.2004.025601 · Cited by 223
Insulin Sensitivity Among Obese Children and Adolescents, According to Degree of Weight Loss
Reinehr, T., Kiess, W., Kapellen, T., & Andler, W. (2004) · Pediatrics · doi:10.1542/peds.2003-0649-f · Cited by 211
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Gorter, P. M., Olijhoek, J. K., van der Graaf, Y., Algra, A., Rabelink, T. J., & Visseren, F. L. J. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.12.033 · Cited by 216
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Preventing Type 2 diabetes and the dysmetabolic syndrome in the real world: a realistic view
Zimmet, P., Shaw, J. E., & Alberti, K. G. M. M. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.01052.x · Cited by 208
Hypertension among HIV patients: prevalence and relationships to insulin resistance and metabolic syndrome.
Gazzaruso, C., Bruno, R., Garzaniti, A., Giordanetti, S., Fratino, P., Sacchi, P., & Filice, G. (2003) · PubMed · doi:10.1097/01.hjh.0000059071.43904.dc · Cited by 208

Authors: Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L.
Affiliations: Department of Internal Medicine, Jakobstad Hospital, Jakobstad, Finland
Lund University (SE)
Helsinki University Hospital (FI)
Närpes Health Center, Närpes
Vasa Health Center
Vaasa Central Hospital (FI)
ORCID: Almgren, Peter
Taskinen, Marja-Riitta
Groop, Leif
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2001-04-01
Volume: 24
Issue: 4
Pages: 683-689
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.24.4.683
OpenAlex: W1986349550
Cited by: 4,760
References: 36
Citations by year: 2026: 27 · 2025: 70 · 2024: 93 · 2023: 88 · 2022: 123 · 2021: 132 · 2020: 128 · 2019: 137 · 2018: 139 · 2017: 153 · 2016: 185 · 2015: 198 · 2014: 218 · 2013: 211 · 2012: 222
FWCI: 100.87
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: Svenska Läkaresällskapet
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: metabolic syndrome, cardiovascular mortality, cardiovascular morbidity, type 2 diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, microalbuminuria, coronary artery disease, stroke, obesity, hypertension, dyslipidemia, WHO definition
MeSH terms: Adult, Age Factors, Aged, Albuminuria, Blood Glucose, Cardiovascular Diseases, Cholesterol, Diabetes Mellitus, Type 2, Family, Female, Finland, Glycated Hemoglobin, Humans, Hyperlipidemias, Hypertension, Insulin Resistance, Cholesterol, HDL, Male, Middle Aged, Morbidity, Obesity, Risk Factors, Sex Factors, Sweden, Triglycerides, Prevalence, Glucose Intolerance

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Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome

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