Cited by 4,760Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk FactorsCardiovascular Health and Risk Factors

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Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome

Isomaa, Bo, Almgren, Peter, Tuomi, Tiinamaija, Forsén, Björn, Lahti, Kaj, Nissén, Michael, Taskinen, Marja-Riitta, Groop, Leif·2001·Diabetes Care

DOI 10.2337/diacare.24.4.683

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Abstract

OBJECTIVE—To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization (WHO). RESEARCH DESIGN AND METHODS—A total of 4,483 subjects aged 35–70 years participating in a large family study of type 2 diabetes in Finland and Sweden (the Botnia study) were included in the analysis of cardiovascular risk associated with the metabolic syndrome. In subjects who had type 2 diabetes (n = 1,697), impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) (n = 798), or insulin-resistance with normal glucose tolerance (NGT) (n = 1,988), the metabolic syndrome was defined as presence of at least two of the following risk factors: obesity, hypertension, dyslipidemia, or microalbuminuria. Cardiovascular mortality was assessed in 3,606 subjects with a median follow-up of 6.9 years. RESULTS—In women and men, respectively, the metabolic syndrome was seen in 10 and 15% of subjects with NGT, 42 and 64% of those with IFG/IGT, and 78 and 84% of those with type 2 diabetes. The risk for coronary heart disease and stroke was increased threefold in subjects with the syndrome (P < 0.001). Cardiovascular mortality was markedly increased in subjects with the metabolic syndrome (12.0 vs. 2.2%, P < 0.001). Of the individual components of the metabolic syndrome, microalbuminuria conferred the strongest risk of cardiovascular death (RR 2.80; P = 0.002). CONCLUSIONS—The WHO definition of the metabolic syndrome identifies subjects with increased cardiovascular morbidity and mortality and offers a tool for comparison of results from different studies.

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Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555
Cardiovascular Survey Methods.
Rose, G., & Blackburn, H. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-69-6-1335_2 · Cited by 3,090
Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents.
Tunstall-Pedoe, H., Kuulasmaa, K., Amouyel, P., Arveiler, D., Rajakangas, A.-M., & Pająk, A. (1994) · Circulation · doi:10.1161/01.cir.90.1.583 · Cited by 2,260
Comment on the provisional report from the WHO consultation
(1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00059.x · Cited by 1,820
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728
The Deadly Quartet
Kaplan, N. M. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.7.1514 · Cited by 1,672
Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
Modan, M., Halkin, H., Almog, S., Lusky, A., Eshkol, A., Shefi, M., Shitrit, A., & Fuchs, Z. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111776 · Cited by 1,465

Show all 36 references

Research works printed but not linked: 2

Descovich GC, Benassi B, Cancelli V, D’Addato S, De Simone, Dormi A: An epidemic view of the plurimetabolic syndrome. In Diabetes, Obesity and Hyperlipidemias. V. The Plurimetabolic Syndrome Crepaleli G, Tiengo A, Manzato E, Eds. Amsterdam, Netherlands, Elsevier Science, 1993, p. 31–39
Bouchard C, Perusse L: Genetics of causes and manifestations of the metabolic syndrome. In Diabetes, obesity and hyperlipidemia: V. The plurimetabolic syndrome Crepaldi G, Tiengo A, Manzato E, Eds., Amsterdam, Elsevier Science, 1993, p. 67–74

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Sigurdardottir, V., Fagerberg, B., & Hulthe, J. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.01054.x · Cited by 144
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ter Horst, R., van den Munckhof, I., Schraa, K., Aguirre‐Gamboa, R., Jaeger, M., Smeekens, S. P., Brand, T., Lemmers, H., Dijkstra, H., Galesloot, T. E., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314508 · Cited by 147
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Skalický, J., Mužáková, V., Kanďár, R., Milan Meloun, A., Roušar, T., & Palička, V. (2008) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2008.096 · Cited by 142
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Bloomgarden, Z. T. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.933 · Cited by 145
KDOQI US Commentary on the 2009 KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients
BIA, M. J., Adey, D., Bloom, R. D., Chan, L. K., Kulkarni, S., & Tomlanovich, S. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2010.04.010 · Cited by 141
Association among cigarette smoking, metabolic syndrome, and its individual components: the metabolic syndrome study in Taiwan
Chen, C., Li, T., Chang, P.-C., Liu, C.-S., Lin, W., Wu, M., Li, C., Lai, M.-M., & Lin, C. (2008) · Metabolism · doi:10.1016/j.metabol.2007.11.018 · Cited by 141
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Characteristics of different phenotypes of polycystic ovary syndrome based on the Rotterdam criteria in a large‐scale Chinese population
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Rizvi, A. A. (2009) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181a4158c · Cited by 138
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Neville, K. A. (2005) · Archives of Disease in Childhood · doi:10.1136/adc.2004.053959 · Cited by 139
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Lee, S. E., Han, K., Kang, Y. M., Kim, S., Cho, Y. K., Ko, K. S., Park, J., Lee, K., & Koh, E. H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194490 · Cited by 142
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Kumari, R., Kumar, S., & Kant, R. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.06.005 · Cited by 144
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Sabag, A., Little, J. P., & Johnson, N. A. (2021) · The Journal of Physiology · doi:10.1113/jp281210 · Cited by 145
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Hägg, S., Lindblom, Y., Mjörndal, T., & Adolfsson, R. (2006) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000188215.84784.17 · Cited by 137
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Gueugneau, M., Coudy-Gandilhon, C., Théron, L., Meunier, B., Barboiron, C., Combaret, L., Taillandier, D., Polge, C., Attaix, D., Picard, B., et al. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu086 · Cited by 137
Three percent weight reduction is the minimum requirement to improve health hazards in obese and overweight people in Japan
Muramoto, A., Matsushita, M., Kato, A., Yamamoto, N., Koike, G., Nakamura, M., Numata, T., Tamakoshi, A., & Tsushita, K. (2013) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2013.10.003 · Cited by 141
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Muntner, P., He, J., Chen, J., Fonseca, V. A., & Whelton, P. K. (2004) · Annals of Epidemiology · doi:10.1016/j.annepidem.2004.01.002 · Cited by 137
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Keller, K. B., & Lemberg, L. (2003) · American Journal of Critical Care · doi:10.4037/ajcc2003.12.2.167 · Cited by 135
Myelin, myelin-related disorders, and psychosis
Mighdoll, M. I., Tao, R., Kleinman, J. E., & Hyde, T. M. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.040 · Cited by 135

Authors: Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L.
Affiliations: Department of Internal Medicine, Jakobstad Hospital, Jakobstad, Finland
Lund University (SE)
Helsinki University Hospital (FI)
Närpes Health Center, Närpes
Vasa Health Center
Vaasa Central Hospital (FI)
ORCID: Almgren, Peter
Taskinen, Marja-Riitta
Groop, Leif
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2001-04-01
Volume: 24
Issue: 4
Pages: 683-689
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.24.4.683
OpenAlex: W1986349550
Cited by: 4,760
References: 36
Citations by year: 2026: 27 · 2025: 70 · 2024: 93 · 2023: 88 · 2022: 123 · 2021: 132 · 2020: 128 · 2019: 137 · 2018: 139 · 2017: 153 · 2016: 185 · 2015: 198 · 2014: 218 · 2013: 211 · 2012: 222
FWCI: 100.87
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: Svenska Läkaresällskapet
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: metabolic syndrome, cardiovascular mortality, cardiovascular morbidity, type 2 diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, microalbuminuria, coronary artery disease, stroke, obesity, hypertension, dyslipidemia, WHO definition
MeSH terms: Adult, Age Factors, Aged, Albuminuria, Blood Glucose, Cardiovascular Diseases, Cholesterol, Diabetes Mellitus, Type 2, Family, Female, Finland, Glycated Hemoglobin, Humans, Hyperlipidemias, Hypertension, Insulin Resistance, Cholesterol, HDL, Male, Middle Aged, Morbidity, Obesity, Risk Factors, Sex Factors, Sweden, Triglycerides, Prevalence, Glucose Intolerance

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Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome

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