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The Continuous Glucose Monitoring System Is Useful for Detecting Unrecognized Hypoglycemias in Patients With Type 1 and Type 2 Diabetes but Is Not Better Than Frequent Capillary Glucose Measurements for Improving Metabolic Control

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Chico, Ana, Vidal-Ríos, Pablo, Subirà, Montserrat, Novials, Anna·2003·Diabetes Care

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Abstract

OBJECTIVE—To evaluate whether the continuous glucose monitoring system (CGMS; MiniMed, Sylmar, CA) is useful for investigating the incidence of unrecognized hypoglycemias in type 1 and type 2 diabetic patients and for improving metabolic control in type 1 diabetic patients. RESEARCH DESIGN AND METHODS—A total of 70 diabetic subjects (40 type 1 and 30 type 2 subjects) were monitored using the CGMS. The number of unrecognized hypoglycemias was registered. Furthermore, the 40 type 1 diabetic patients whose treatment was modified in accordance with the information obtained from the CGMS were compared with a control group of 35 different type 1 diabetic patients using intensive capillary glucose measurements. HbA1c levels were measured before the monitoring period and 3 months later. RESULTS—The CGMS detected unrecognized hypoglycemias in 62.5% of the type 1 diabetic patients and in 46.6% of the type 2 diabetic patients. We found that 73.7% of all events occurred at night. HbA1c concentrations decreased significantly in both the group of type 1 diabetic subjects monitored with the CGMS (from 8.3 ± 1.6 to 7.5 ± 1.2%, P < 0.01) and the control group (from 8.0 ± 1.4 to 7.5 ± 0.8%, P < 0.01). The greatest reduction was observed in the subgroup of patients who started continuous subcutaneous insulin infusion therapy, both in the CGMS-monitored and control groups (from 9.4 ± 2 to 7.2 ± 1.4% and from 8.1 ± 1.8 to 7.1 ± 0.6%, respectively). CONCLUSIONS—The CGMS is useful for detecting unrecognized hypoglycemias in type 1 and type 2 diabetic subjects; however, it is not better than standard capillary glucose measurements for improving metabolic control of type 1 diabetic subjects, regardless of the therapeutic regimen.

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Authors: Chico, A., Vidal-Ríos, P., Subirà, M., & Novials, A.
Affiliations: Institute of Diabetology, Fundació Sardà Farriol, Barcelona, Spain
Diabetes Center, La Coruña, Spain
ORCID: Chico, Ana
Novials, Anna
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2003-04-01
Volume: 26
Issue: 4
Pages: 1153-1157
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.26.4.1153
OpenAlex: W2165449026
Cited by: 235
References: 23
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 3 · 2020: 4 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 9 · 2015: 20 · 2014: 10 · 2013: 13 · 2012: 14
FWCI: 8.13
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: continuous glucose monitoring, type 1 diabetes, type 2 diabetes, glycemic control, HbA1c, nocturnal hypoglycemia, insulin pump therapy
MeSH terms: Adult, Blood Glucose, Capillaries, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Hypoglycemia, Male, Gas Chromatography-Mass Spectrometry, Middle Aged, Monitoring, Physiologic, Monitoring, Ambulatory

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The Continuous Glucose Monitoring System Is Useful for Detecting Unrecognized Hypoglycemias in Patients With Type 1 and Type 2 Diabetes but Is Not Better Than Frequent Capillary Glucose Measurements for Improving Metabolic Control

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