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Cited by 242Phagocytosis and Immune RegulationImmune Response and InflammationCell death mechanisms and regulation

Immunological Consequences of Apoptotic Cell Phagocytosis

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Erwig, Lars-Peter, Henson, Peter M.·2007·The American Journal of Pathology
DOI 10.2353/ajpath.2007.070135PMC PMC1941587
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Abstract

Cells undergo apoptosis in development, tissue homeostasis, and disease and are subsequently cleared by professional and nonprofessional phagocytes. There is now overwhelming evidence that phagocyte function is profoundly altered following apoptotic cell uptake, with consequences for the ensuing innate and adaptive immune response. Pathogens and tumors exploit the changes in macrophage function following apoptotic cell uptake. Here, we will outline the consequences of apoptotic cell phagocytosis and illustrate how apoptotic cells could be used to manipulate the immune response for therapeutic gain.

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  • Macrophages remove apoptotic neutrophils, and this phagocytosis may lead to a change toward reparative M2 phenotype and resolution of inflammation.

    “Macrophages also remove apoptotic neutrophils, the phagocytosis of which may lead to a change toward a more reparative (M2) macrophage phenotype and the resolution of the inflammatory phase of wound healing [94–96].”

    From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [94]

  • The mechanisms of the M1 to M2 switch during dermal remodeling are not well described but are thought to include phenotypic changes caused by phagocytosis of apoptotic cells and debris by M1 macrophages.

    “The mechanisms of this switch from an M1 to an M2 phenotype during dermal remodeling are not well described, but are thought to include phenotypic changes caused by the phagocytosis of apoptotic cells and debris by M1 macrophages [94–96].”

    From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [94]

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Cited by

Sorted by citations

Authors
Erwig, L.-P., & Henson, P. M.
Affiliations
  • University of Aberdeen (GB)
  • National Jewish Health (US)
Corresponding author
Erwig, Lars-Peter
ORCID
Henson, Peter M.
Venue
The American Journal of Pathology
Publisher
Elsevier BV
Published
2007-07
Volume
171
Issue
1
Pages
2-8
ISSN
0002-9440 (ISSN-L)
DOI
10.2353/ajpath.2007.070135
PMC
PMC1941587
OpenAlex
W2057064377
Cited by
242
References
7
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 12 · 2020: 4 · 2019: 6 · 2018: 13 · 2017: 10 · 2016: 10 · 2015: 18 · 2014: 13 · 2013: 20 · 2012: 23
FWCI
1.77
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • American Journal Of Pathology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust (073566)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
phagocytosis of apoptotic cells, macrophage function, innate immunity, adaptive immunity, immune regulation, tumor immune evasion, pathogen immune evasion, immunomodulation, professional phagocytes
MeSH terms
Humans, Immunity, Active, Immunity, Innate, Inflammation, Lymphocyte Activation, Macrophages, Phagocytosis, T-Lymphocytes, Autoimmunity, Apoptosis

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