Use of injectable lufenuron for treatment of infestations of Ctenocephalides felis in cats
Open accessAbstract
Objective: To determine whether and for how long a single dose of a new injectable formulation of lufenuron would successfully control experimentally induced Ctenocephalides felis infestations in cats. Animals: 15 cats (3 groups of 5). Procedure: Each group of cats was housed in a separate room. Each cat was infested with 150 fleas, and flea counts were checked weekly. Once flea populations had stabilized, cats were treated with lufenuron at a dosage of 5 mg/kg of body weight, SC (group 1) or 10 mg/kg, SC (group 2). Group-3 cats were not treated. Flea counts were checked weekly for 18 weeks, and effectiveness was determined by comparing flea counts for treated cats with flea counts for control cats. Cats were reinfested with fleas during weeks 19, 26, 36, and 49, and flea counts were again determined weekly. Results: Effectiveness for both dosages of lufenuron was > 90% by 5 weeks after treatment, > 95% by 9 weeks after treatment, and > 98% by 13 weeks after treatment. Reinfestations performed during weeks 19 and 26 were well controlled (ie, > 90% reduction in flea counts, compared with control group) in both groups of cats treated with lufenuron. Reinfestations performed during week 36 were well controlled only in cats treated with lufenuron at the higher dosage. Reinfestations performed during week 49 were not controlled in either group of treated cats. Conclusions: A single dose of the new injectable formulation of lufenuron should control flea populations in cats for up to 26 weeks, even among cats that are periodically reinfested with fleas. (Am J Vet Res 1997;58:140–142)
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lufenuron is highly effective when used alone in simulated home environments with induced flea infestations.
“Lufenuron proved to be highly effective when used alone in simulated home environments with induced flea infestations [129-131]”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [131]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cited by
Sorted by citations
Insecticide and acaricide molecules and/or combinations to prevent pet infestation by ectoparasites
Beugnet, F., & Franc, M. (2012) · Trends in Parasitology · doi:10.1016/j.pt.2012.04.004 · Cited by 164 · see citing works
Self-citationThe Biology and Ecology of Cat Fleas and Advancements in Their Pest Management: A Review
Rust, M. Κ. (2017) · Insects · doi:10.3390/insects8040118 · Cited by 164 · see citing works
“An injectable formulation of lufenuron in cats provided >95% control by week 9 and this continued at >90% reductions for 26 weeks in simulated home environments [249].”
BackgroundTherapy, control and prevention of flea allergy dermatitis in dogs and cats
Carlotti, D., & Jacobs, D. E. (2000) · Veterinary Dermatology · doi:10.1046/j.1365-3164.2000.00204.x · Cited by 84 · see citing works
Junquera, P., Hosking, B. C., Gameiro, M., et al. (2019) · Parasite · doi:10.1051/parasite/2019026 · Cited by 58 · see citing works
“A single injection at the recommended therapeutic dose (10 mg/kg) ensured >90% prevention of re-infestation for up to six months [115, 254].”
BackgroundFleas infesting pets in the era of emerging extra-intestinal nematodes
Traversa, D. (2013) · Parasites & Vectors · doi:10.1186/1756-3305-6-59 · Cited by 53 · see citing works
“used alone in simulated home environments with induced flea infestations [129-131], but a fast acting”
MethodJacobs, D. E., Hutchinson, M. J., & Ryan, W. G. (2001) · Medical and Veterinary Entomology · doi:10.1046/j.1365-2915.2001.00270.x · Cited by 33 · see citing works
“…Infectious Diseases, The Royal Veterinary College, North Mymms, Hat®eld, Herts AL9 7TA, U.K. E-mail: djacobs@rvc.ac.uk # 2001 Blackwell Science Ltd 73 will induce infertility in ¯eas feeding on cats for up to 6 months following administration by subcutaneous injection (Franc & Cadiergues, 1997).”
MethodInfluentialMarsella, R. (1999) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/s0195-5616(99)50135-6 · Cited by 22 · see citing works
Ritzhaupt, L. K., Rowan, T. G., Jones, R. L., Cracknell, V. C., Murphy, M. G., & Shanks, D. J. (2002) · Veterinary Parasitology · doi:10.1016/s0304-4017(02)00051-1 · Cited by 17 · see citing works
Woodward, K. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849733007-00348 · Cited by 11 · see citing works
Animal Health Markets and Opportunities: Companion Animal Landscape
Horspool, L. J. I. (2012) · Advances in delivery science and technology · doi:10.1007/978-1-4614-4439-8_2 · Cited by 5 · see citing works
“In the early 1990s, lufenuron, a benzoylurea, was shown to be effective against developing stages of fl eas after oral administration once monthly [ 106– 109 ] and as a longacting (6-monthly) injectable formulation [ 110 ] , relying on subcutaneous tissue reservoirs for sustained activity.”
BackgroundVeterinary Products Containing Pesticide Active Ingredients
Woodward, K. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849735483-00150 · Cited by 2 · see citing works
Cadiergues, M. (2013) · Wiley eBooks · doi:10.1002/9781118738818.ch41 · Cited by 1 · see citing works
Self-citationCan Lufenuron be an alternative treatment option in small animal dermatomycosis?
Bilgiç, B., Dokuzeylül, B., Bakay, B. B., & Or, M. E. (2021) · GMPC Thesis & Opinions Platform · doi:10.51585/gtop.2021.2.0009
- Authors
- Franc, M., & Cadiergues, M.-C.
- Affiliations
- École Nationale Vétérinaire de Toulouse (FR)
- Venue
- American Journal of Veterinary Research
- Published
- 1997-02-01
- Volume
- 58
- Issue
- 2
- Pages
- 140-142
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W2399337448
- Cited by
- 13
- References
- 0
- Citations by year
- 2021: 1 · 2019: 1 · 2017: 1 · 2013: 2 · 2012: 4
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Yersinia bacterium, plague, ectoparasites research
- Keywords
- lufenuron, Ctenocephalides felis, fleas, injectable formulation, flea control, reinfestation, dose comparison, cats
- MeSH terms
- Animals, Benzamides, Cat Diseases, Cats, Diptera, Ectoparasitic Infestations, Female, Siphonaptera, Fluorocarbons, Injections, Subcutaneous, Insecticides, Male, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
