Chemical composition, antioxidant, anti-elastase, and anti-inflammatory activities of Illicium anisatum essential oil
Open accessAbstract
The essential oil of air-dried Illicium anisatum (Illiciaceae), obtained by hydrodistillation was analyzed by gas chromatography-mass spectrometry (GC-MS). Fifty-two components were identified in the essential oil and the main component was eucalyptol (21.8 %). The antioxidant and anti-elastase activities of the essential oil were also investigated; the essential oil exhibited moderate DPPH scavenging and anti-elastase activities. To clarify the mechanism of the anti-inflammatory activities of I. anisatum essential oil (IAE), we evaluated whether it could modulate the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by activated macrophages. The results indicate that IAE is an effective inhibitor of LPS-induced NO and PGE2 production in RAW 264.7 cells. These inhibitory activities were accompanied by dose-dependent decreases in the expression of iNOS and COX-2 proteins and iNOS and COX-2 mRNA. In order to determine whether IAE can be safely applied to human skin, the cytotoxic effects of IAE were determined by colorimetric MTT assays in human dermal fibroblast and keratinocyte HaCaT cells. IAE exhibited low cytotoxicity at 100 microg mL-1. Based on these results, we suggest that IAE may be considered an anti-aging and anti-inflammatory candidate for cosmetic materials, but additional in vitro and in vivo tests have to be performed to prove its safety and efficacy.
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Illicium anisatum essential oil inhibits NO and PGE2 production in LPS-stimulated RAW 264.7 cells along with decrease of iNOS and COX-2 proteins and iNOS and COX-2 mRNA expression.
“The same authors in another work, and using the essential oil of Illicium anisatum L., mainly constituted by 1,8-cineole, also demonstrated its capacity for inhibiting NO and PGE2 production in LPS-stimulated RAW 264.7 cells, along with the decrease of iNOS and COX-2 proteins and iNOS and COX-2 mRNA expression [145].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [145]
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- Authors
- Kim, J.-Y., Kim, S.-S., Oh, T.-H., Baik, J., Song, G., Lee, N., & Hyun, C.-G.
- Affiliations
- Jeju National University (KR)
- Venue
- Acta Pharmaceutica
- Publisher
- Walter de Gruyter GmbH
- Published
- 2009-01-01
- Volume
- 59
- Issue
- 3
- Pages
- 289-300
- ISSN
- 1330-0075 (ISSN-L)
- 1846-9558
- OpenAlex
- W2011856237
- Cited by
- 38
- References
- 13
- Citations by year
- 2025: 2 · 2024: 3 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 3 · 2015: 2 · 2013: 3 · 2012: 4
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Acta Pharmaceutica (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- University of Zagreb University Computing Centre (SRCE) (submittedVersion, other-oa)
- Funders
- Ministry of Knowledge Economy
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Health Sciences › Medicine › Rehabilitation › Magnolia and Illicium research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Illicium anisatum, essential oils, chemical composition, 1,8-cineole, antioxidant activity, anti-elastase activity, anti-inflammatory activity, nitric oxide, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, macrophages, cytotoxicity, dermal fibroblasts, keratinocytes, anti-aging cosmetics, skin care
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Cell Line, Cell Survival, Dose-Response Relationship, Drug, Fibroblasts, Humans, Oils, Volatile, Pancreatic Elastase, Protease Inhibitors, Skin, Swine, Keratinocytes, Plant Leaves, Illicium, Mice
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