Chemical Composition and Anti-inflammatory Effects of Essential Oil from Farfugium japonicum Flower
Open accessAbstract
In this study, the chemical composition and anti-inflammatory activities of hydrodistilled essential oil from Farfugium japonicum were investigated for the first time. The chemical constituents of the essential oil were further analyzed by GC-MS and included 1-undecene (22.43%), 1-nonene (19.83%), beta-caryophyllene (12.26%), alpha-copaene (3.70%), gamma-curcumene (2.86%), germacrene D (2.69%), and 1-decene (2.08%). The effects of the essential oil on nitric oxide (NO) and prostaglandin E2 (PGE(2)) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were also examined. The results indicate that the F. japonicum essential oil is an effective inhibitor of LPS-induced NO and PGE(2) production in RAW 264.7 cells. These inhibitory effects of the F. japonicum essential oil were accompanied by dose-dependent decreases in the iNOS and COX-2 mRNA expression. In order to determine whether F. japonicum essential oil can safely be applied to human skin, the cytotoxic effects of F. japonicum essential oil were determined by colorimetric MTT assays in human dermal fibroblast and keratinocyte HaCaT cells. F. japonicum essential oil exhibited low cytotoxicity at 100 mug/mL. Based on these results, we suggest that F. japonicum essential oil may be considered a potential anti-inflammatory candidate for topical application.
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Farfugium japonicum essential oil inhibits NO and PGE2 production in LPS-stimulated RAW 264.7 cells with concomitant inhibition of iNOS and COX-2 mRNA expression.
“An inhibitory effect of Farfugium japonicum (L.) Kitamura essential oil, namely constituted by 1-undecene, 1-nonene and β-caryophyllene, on NO and PGE2 production in LPS-stimulated RAW 264.7 cells were found by Kim et al. (2008) [144], with a concomitant inhibition of iNOS and COX-2 mRNA expression, might explain the anti-inflammatory activity of this oil.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [144]
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- Authors
- Kim, J.-Y., Oh, T.-H., Kim, B. J., Kim, S.-S., Lee, N. H., & Hyun, C.-G.
- Affiliations
- Research Group of Cosmetic Materials, Jeju Biodiversity Research Institute (JBRI), and Jeju Hi-Tech Industry Development Institute (HiDI)
- Department of Chemistry, Cheju National University
- Jeju Science High School
- Venue
- Journal of Oleo Science
- Publisher
- Japan Oil Chemists' Society
- Published
- 2008
- Volume
- 57
- Issue
- 11
- Pages
- 623-628
- ISSN
- 1341-8327 (ISSN-L)
- 1345-8957
- 1347-3352
- OpenAlex
- W2022432517
- Cited by
- 49
- References
- 19
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Oleo Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Farfugium japonicum, essential oils, chemical composition, anti-inflammatory activity, 1-undecene, β-caryophyllene, nitric oxide, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, macrophages, cytotoxicity, topical application
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Line, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Fibroblasts, Humans, Lipopolysaccharides, Macrophages, Nitric Oxide, Plant Oils, RNA, Messenger, Dinoprostone, Gene Expression Regulation, Enzymologic, Asteraceae, Flowers, Mice, Cyclooxygenase 2, Nitric Oxide Synthase Type II
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