The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
The biology of leptin: a review.
Abstract
Leptin, a 16-kDa protein secreted from white adipocytes, has been implicated in the regulation of food intake, energy expenditure, and whole-body energy balance in rodents and humans. The gene encoding leptin was identified by positional cloning and is the mutation leading to the profound obese phenotype of the ob/ob mouse. Exogenous administration of leptin to ob/ob mice leads to a significant improvement in reproductive and endocrine status as well as reduced food intake and weight loss. The expression and secretion of leptin is highly correlated with body fat mass and adipocyte size. Cortisol and insulin are potent stimulators of leptin expression, and expression is attenuated by beta-adrenergic agonists, cAMP, and thiazolidinediones. The role of other hormones and growth factors in the regulation of leptin expression and secretion is emerging. Leptin circulates specifically bound to proteins in serum, which may regulate its half-life and biological activity. Isoforms of the leptin receptor, members of the interleukin-6 cytokine family of receptors, are found in multiple tissues, including the brain. Many of leptin's effects on food intake and energy expenditure are thought to be mediated centrally via neurotransmitters such as neuropeptide Y. Multiple peripheral effects of leptin have also been recently described, including the regulation of insulin secretion by pancreatic beta cells and regulation of insulin action and energy metabolism in adipocytes and skeletal muscle. Leptin is thought to be a metabolic signal that regulates nutritional status effects on reproductive function. Leptin also plays a major role in hematopoeisis and in the anorexia accompanying an acute cytokine challenge. The profound effects of leptin on regulating body energy balance make it a prime candidate for drug therapies for humans and animals.
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1 retracted
Leptin Stimulates Fetal and Adult Erythroid and Myeloid Development
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RetractedPositional cloning of the mouse obese gene and its human homologue
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Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
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Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels*
Aguilar-Bryan, L., & Bryan, J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.2.0361 · Cited by 698
BOARD-INVITED REVIEW: The biology and regulation of preadipocytes and adipocytes in meat animals1,2
Hausman, G. J., Dodson, M. V., Ajuwon, K., Azain, M., Barnes, K. M., Guan, L. L., Jiang, Z., Poulos, S. P., Sainz, R. D., Smith, S., et al. (2009) · Journal of Animal Science · doi:10.2527/jas.2008-1427 · Cited by 342
Self-citationSchenkel, F. S., Miller, S. P., Ye, X., Moore, S. S., Nkrumah, J. D., Li, C., Yu, J., Mandell, I. B., Wilton, J. W., & Williams, J. L. (2005) · Journal of Animal Science · doi:10.2527/2005.8392009x · Cited by 317
Nutrition, metabolism, and the complex pathophysiology of cachexia in chronic heart failure
VONHAEHLING, S., DOEHNER, W., & ANKER, S. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.08.018 · Cited by 300
Metadata
- Authors
- Houseknecht, K. L., Baile, C. A., Matteri, R. L., & Spurlock, M. E.
- Venue
- Journal of Animal Science
- Publisher
- Oxford University Press (OUP)
- Published
- 1998
- Volume
- 76
- Issue
- 5
- Pages
- 1405
- ISSN
- 0021-8812 (ISSN-L)
- OpenAlex
- W6013967
- Cited by
- 744
- References
- 151
- FWCI
- 12.51
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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