The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Brown fat biology and thermogenesis
Open accessAbstract
Brown fat (brown adipose tissue, BAT) primary function is to produce heat. There is now compelling evidence to indicate that brown fat cells in some BAT depots share their predecessor cells with myocytes. Brown adipocyte (trans)differentiation depends on various receptors / transcription factors that include peroxisome proliferator-activated receptor g (PPARgamma), PPARgamma-coactivator-1alpha (PGC1alpha), PRD1-BF1-RIZ1 homologous domain-containing 16 (PRDM16), CCAAT/enhancer-binding protein beta (C/EBP-beta) and bone morphogenetic protein 7 (BMP7). Such mediators also help BAT to acquire its thermogenic phenotype, which is essentially conferred by uncoupling protein 1 (UCP1). UCP1 uncouples adenosine-5'-triphosphate (ATP) synthesis from substrate oxidation in brown adipocytes. Its activity depends on the availability of fatty acids delivered upon BAT's beta)-adrenergic activation, which, physiologically, ensues from the sympathetic nervous system (SNS) activation of the tissue. SNS-mediated thermogenesis is largely controlled by the hypothalamus and brainstem. Recently, positron emission tomography / computed tomography (PET/CT) scanning investigations have revealed the presence in adult humans of important neck and shoulder BAT depots. That finding has contributed to reinstate a strong interest for brown adipocyte biology and thermogenesis. This review aims at the unique biology of BAT with the emphasis put on the recent discoveries regarding the brown adipocyte development and function.
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Cites
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“There is now compelling evidence (6-9, 35) to suggest that brown adipocytes from classical BAT depots share their precursor cells with myocytes (Figure 1).”
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“UCP1 is activated by fatty acids, which override the inhibitory action of purine nucleotides on UCP1 (1, 11, 90, 103) (Figure 2).”
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Cited by
Brown adipose tissue: Development, metabolism and beyond
Schulz, T. J., & Tseng, Y.-H. (2013) · Biochemical Journal · doi:10.1042/bj20130457 · Cited by 173
Understanding the brown adipocyte as a contributor to energy homeostasis
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Self-citationThe emerging neuroprotective role of mitochondrial uncoupling protein-2 in traumatic brain injury
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Pilling, D., Cox, N., Thomson, M. A., Karhadkar, T. R., & Gomer, R. H. (2019) · The American Journal of Pathology · doi:10.1016/j.ajpath.2019.08.005 · Cited by 17
Mendes, C., Gomes, G., Belpiede, L. T., do Carmo Buonfiglio, D., Motta-Teixeira, L. C., Amaral, F. G., & Cipolla-Neto, J. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118769 · Cited by 17
Cong, H., Zhong, W., Wang, Y., Ikuyama, S., Fan, B., & Gu, J. (2018) · Journal of Diabetes Research · doi:10.1155/2018/9713259 · Cited by 9
Metadata
- Authors
- Richard, D.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2011
- Volume
- 16
- Issue
- 1
- Pages
- 1233
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/3786
- OpenAlex
- W2073765502
- Cited by
- 247
- References
- 25
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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