The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Effects of Vitamin C on health: a review of evidence
Open accessAbstract
Vitamin C is an essential dietary nutrient for the biosynthesis of collagen and a co-factor in the biosynthesis of catecholamines, L-carnitine, cholesterol, amino acids, and some peptide hormones. The lack of vitamin C causes scurvy, a pathological condition leading to blood vessel fragility and connective tissue damage due to failure in producing collagen, and, finally, to death as result of a general collapse. Vitamin C is potentially involved also in cancer and cardiovascular diseases prevention. In addition, vitamin C effects on nervous system and chronically ill patients have been also documented. This review attempts to summarize recent and well established advances in vitamin C research and its clinical implications. Since vitamin C has the potential to counteract inflammation and subsequent oxidative damage that play a major role in the initiation and progression of several chronic and acute diseases, it represents a practical tool to administer for the early prevention of these pathologic conditions.
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Cites
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Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
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Cited by
Yin, X., Chen, K., Cheng, H., Chen, X., Feng, S., Song, Y., & Liang, L. (2022) · Antioxidants · doi:10.3390/antiox11010153 · Cited by 369
Vitamin C, Aging and Alzheimer’s Disease
Monacelli, F., Acquarone, E., Giannotti, C., Borghi, R., & Nencioni, A. (2017) · Nutrients · doi:10.3390/nu9070670 · Cited by 243
“In addition, in the CNS, AA participated in several hydroxylation reactions that include the redox activity of Fe3+ and Cu2+ at dioxigenase sites.”
BackgroundInfluentialAscorbic Acid: Its Role in Immune System and Chronic Inflammation Diseases
Sorice, A., Guerriero, E., Capone, F., Colonna, G., Castello, G., & Costantini, S. (2014) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557514666140428112602 · Cited by 212
Vitamin C and immune cell function in inflammation and cancer
Ang, A., Pullar, J. M., Currie, M. J., & Vissers, M. C. M. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180169 · Cited by 191
Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence
Vissers, M. C. M., & Das, A. B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00809 · Cited by 188
“The ability to reduce transition metals is likely to be fundamental to the activity of ascorbate as an essential co-factor for many Fe- and Cu-containing enzymes; in this capacity it ensures that enzyme activity is optimized by the maintenance of the activesite metals in the reduced state (Kivirikko et al., 1989; Rebo…”
Metadata
- Authors
- Bei, R.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2013
- Volume
- 18
- Issue
- 3
- Pages
- 1017
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/4160
- OpenAlex
- W1981165812
- Cited by
- 259
- References
- 147
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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