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Effects of Vitamin C on health: a review of evidence

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Bei, Roberto·2013·Frontiers in Bioscience

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Abstract

Vitamin C is an essential dietary nutrient for the biosynthesis of collagen and a co-factor in the biosynthesis of catecholamines, L-carnitine, cholesterol, amino acids, and some peptide hormones. The lack of vitamin C causes scurvy, a pathological condition leading to blood vessel fragility and connective tissue damage due to failure in producing collagen, and, finally, to death as result of a general collapse. Vitamin C is potentially involved also in cancer and cardiovascular diseases prevention. In addition, vitamin C effects on nervous system and chronically ill patients have been also documented. This review attempts to summarize recent and well established advances in vitamin C research and its clinical implications. Since vitamin C has the potential to counteract inflammation and subsequent oxidative damage that play a major role in the initiation and progression of several chronic and acute diseases, it represents a practical tool to administer for the early prevention of these pathologic conditions.

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“In addition, in the CNS, AA participated in several hydroxylation reactions that include the redox activity of Fe3+ and Cu2+ at dioxigenase sites.”
BackgroundInfluential
Ascorbic Acid: Its Role in Immune System and Chronic Inflammation Diseases
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Vitamin C and immune cell function in inflammation and cancer
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Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence
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“The ability to reduce transition metals is likely to be fundamental to the activity of ascorbate as an essential co-factor for many Fe- and Cu-containing enzymes; in this capacity it ensures that enzyme activity is optimized by the maintenance of the activesite metals in the reduced state (Kivirikko et al., 1989; Rebo…”

See all 259

Authors: Bei, R.
Venue: Frontiers in Bioscience
Publisher: IMR Press
Published: 2013
Volume: 18
Issue: 3
Pages: 1017
ISSN: 1093-4715 (ISSN-L)
1093-9946
DOI: 10.2741/4160
OpenAlex: W1981165812
Cited by: 259
References: 147
FWCI: 9.70
Type: journal article
Language: en
Open access: bronze

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Effects of Vitamin C on health: a review of evidence

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