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T cells and aging

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Pawelec, Graham·1998·Frontiers in Bioscience

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Abstract

Deterioration of the immune system with aging ("immunosenescence") is believed to contribute to morbidity and mortality in man due to the greater incidence of infection, as well as possibly autoimmune phenomena and cancer in the aged. Dysregulation of T cell function is thought to play a critical part in these processes. Factors contributing to T cell immunosenescence may include a) stem cell defects, b) thymus involution, c) defects in antigen presenting cells (APC), d) aging of resting immune cells, e) disrupted activation pathways in immune cells, f) replicative senescence of clonally expanding cells. This review aims to consider the current state of knowledge on the scientific basis for and potential clinical relevance of those factors in immunosenescence.

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Self-citation
Innate immunity and inflammation in ageing: a key for understanding age-related diseases
Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C., & Caruso, C. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-8 · Cited by 453

See all 357

Authors: Pawelec, G.
Venue: Frontiers in Bioscience
Publisher: IMR Press
Published: 1998
Volume: 3
Issue: 4
Pages: d59-99
ISSN: 1093-4715 (ISSN-L)
1093-9946
DOI: 10.2741/a266
OpenAlex: W2336942609
Cited by: 357
References: 459
FWCI: 4.42
Type: journal article
Language: en
Open access: bronze

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