T cells and aging

CD7– T cells in rheumatoid arthritis

Lazarovits, A. I., White, M. J., & Karsh, J. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780350604 · Cited by 30

Aged Murine T-lymphocytes Are More Resistant to Oxidative Damage Due to the Predominance of the Cells Possessing the Memory Phenotype

Lohmiller, J. J., Roellich, K. M., Toledano, A. Y., et al. (1996) · The Journals of Gerontology Series A · doi:10.1093/gerona/51a.2.b132 · Cited by 30

Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70

Chakravarti, B., Chakravarti, D. N., Devecis, J., et al. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00049-9 · Cited by 29

The Age‐Associated Increase in Autoreactive Immunoglobulins Reflects a Quantitative Increase in Specificities Detectable at Lower Concentrations in Young Mice

Nóbrega, A., Haury, M., Gueret, R., Coutinho, A., & Weksler, M. E. (1996) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1996.d01-335.x · Cited by 29

Age-dependent changes in the expression of dopamine receptor subtypes in human peripheral blood lymphocytes

Barili, P., Bronzetti, E., Felici, L., Ferrante, F., Rícci, A., Zaccheo, D., & Amenta, F. (1996) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00127-0 · Cited by 28

Age-related changes in the absolute number of CD95 positive cells in T cell subsets in the blood

Aspinall, R., Carroll, J., & Jiang, S. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00035-7 · Cited by 28

Vitamin E prevents oxidative modification of brain and lymphocyte band 3 proteins during aging.

Poulin, J. E., Cover, C., Gustafson, M. R., & Kay, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5600 · Cited by 27

In Vitro Effects of Melatonin on Mitogen-Induced Lymphocyte Proliferation and Cytokine Expression in Young and Old Rats

Pahlavani, M. A., & Harris, M. D. (1997) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979709046979 · Cited by 27

Age-Sensitive T Cell Phenotypes Covary in Genetically Heterogeneous Mice and Predict Early Death From Lymphoma

Miller, R. A., Turke, P. W., Chrisp, C. E., Ruger, J. K., Luciano, A. E., Peterson, J., Chalmers, K., Gorgas, G., & VanCise, S. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.6.b255 · Cited by 27

Stress Exacerbates Age-Related Decrements in the Immune Response to an Experimental Influenza Viral Infection

Padgett, D. A., MacCallum, R. C., & Sheridan, J. F. (1998) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/53a.5.b347 · Cited by 26

Age-Associated Decline in cdk1 Activity Delays Cell Cycle Progression of Human T Lymphocytes

Quadri, R. A., Arbogast, A., Phelouzat, M.-A., Boutet, S. C., Plastre, O., & Proust, J. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5203 · Cited by 26

Aging of the recipients but not of the bone marrow donors enhances autoimmunity in syngeneic radiation chimeras

Doria, G., Mancini, C., Utsuyama, M., Frasca, D., & Hirokawa, K. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)01871-x · Cited by 26

Pathogenic and protective correlates of T cell proliferation in AIDS. HNRC Group. HIV Neurobehavioral Research Center.

Schrier, R. D., Wiley, C. A., Spina, C. A., McCutchan, J. A., & Grant, I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118845 · Cited by 26

Phosphorylation and coupling of ζ-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans

Whisler, R. L., Karanfilov, C. I., Newhouse, Y. G., Fox, C. C., Lakshmanan, R. R., & Beiqing, L. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00084-0 · Cited by 26

Genetics of life span in mice

Yunis, E. J., & Salazar, M. (1993) · Genetica · doi:10.1007/bf01435999 · Cited by 26

An Age-Related Decrease in Rescue from T Cell Death Following Costimulation Mediated by CD28

Engwerda, C. R., Handwerger, B. S., & Fox, B. S. (1996) · Cellular Immunology · doi:10.1006/cimm.1996.0144 · Cited by 26

Enhanced immune responses and resistance against infection in aged mice conferred by Flu-ISCOMs vaccine correlate with up-regulation of costimulatory molecule CD86

Sambhara, S. R. (1998) · Vaccine · doi:10.1016/s0264-410x(98)00130-3 · Cited by 26

GROWTH HORMONE AS THERAPY FOR OLDER MEN AND WOMEN

Marcus, R., & Hoffman, A. R. (1998) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.45 · Cited by 26

Expression of the human T cell antigen receptor complex in advanced age

OLEARY, J., FOX, R., Bergh, N., Rodysill, K. J., & Hallgren, H. M. (1988) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(88)90006-1 · Cited by 25

Activation of NK1.1+T Cellsin Vitroand Their Possible Role in Age-Associated Changes in Inducible IL-4 Production

Poynter, M. E., Mu, H., Chen, X., & Daynes, R. A. (1997) · Cellular Immunology · doi:10.1006/cimm.1997.1141 · Cited by 25

Soluble Interleukin-2 Receptors and Auto Antibodies in the Serum of Healthy Elderly Individuals

Manoussakis, M. N., Stavropoulos, E., Germanidis, G., Papasteriades, C., Garalea, K. L., Dontas, A. S., & Moutsopoulos, H. Μ. (1990) · Autoimmunity · doi:10.3109/08916939008993385 · Cited by 25

Effects of a protein-free diet or food restriction on the immune system of Wistar and Buffalo rats at different ages

Konno, A., Utsuyama, M., Kurashima, C., Kasai, M., Kimura, S., & Hirokawa, K. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90099-d · Cited by 25

Age-Related Changes of Cytokine Production by Murine Helper T Cell Subpopulations

Kurashima, C., & Utsuyama, M. (2008) · Pathobiology · doi:10.1159/000164117 · Cited by 25

Melatonin: immune modulation of spleen cells in young, middle-aged and senescent mice

Atre, D., & Blumenthal, E. J. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00046-3 · Cited by 24

Altered Switch in Lipid Composition During T-Cell Blast Transformation in the Healthy Elderly

Stulnig, T. M., Biihler, E., de Bock, G. H., Kirchebner, C., Schönitzer, D., & WICK, G. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.6.b383 · Cited by 24

An antibody specific for interleukin‐6 reverses age‐associated changes in spontaneous and induced cytokine production in mice

Gorczynski, R. M., Cinader, B., RAMAKRISHNA, V., Terzıoğlu, E., Waelli, T., & Westphal, O. (1997) · Immunology · doi:10.1046/j.1365-2567.1997.00327.x · Cited by 23

Thymocytopoiesis in aging: the bone marrow-thymus axis

Globerson, A. (1997) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(96)00747-9 · Cited by 23

Telomerase Activity, Telomere Length, and Chromosome Aberrations in the Extension of Life Span of Human Embryo Cells Induced by Low-dose X-rays.

Yang, Z., Kodama, S., Suzuki, K., & Watanabe, M. (1998) · Journal of Radiation Research · doi:10.1269/jrr.39.35 · Cited by 23

Moderate Caloric Restriction Prevents the Age-Related Decline in Growth Hormone Receptor Signal Transduction

Xu, X., & Sonntag, W. E. (1996) · The Journals of Gerontology Series A · doi:10.1093/gerona/51a.2.b167 · Cited by 23

The age-related changes in DNA binding activity of AP-1, NF-κB, and OCT-1 transcription factors in lymphocytes from rats

Pahlavani, M. A., & Harris, M. D. (1996) · AGE · doi:10.1007/bf02434070 · Cited by 22

Decreased Association of p56lckwith CD4 May Account for Lowered Tyrosine Kinase Activity in Mitogen-Activated Human T Lymphocytes during Aging

Tinkle, C. W., Lipschitz, D. A., & Ponnappan, U. (1998) · Cellular Immunology · doi:10.1006/cimm.1998.1313 · Cited by 22

An increase in basal glucocorticoid concentration with age induces suppressor macrophages with high‐density FcγRII/III

Kizaki, Ookawara, OH‐ISHI, Itoh, Y., Iwabuchi, Onoe, Day, Good, & Ohno (1998) · Immunology · doi:10.1046/j.1365-2567.1998.00433.x · Cited by 21

Cytokine-Driven Immortalization of in vitro Activated Human T Lymphocytes

Kaltoft, K. (1998) · Experimental and Clinical Immunogenetics · doi:10.1159/000019058 · Cited by 21

Phytohemagglutinin induced changes of membrane lipid packing , c-myc and c-myb encoded protein expression in human lymphocytes during aging

Pieri, C., Recchioni, R., Moroni, F., Marcheselli, F., & Lipponi, G. (1992) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(92)90105-m · Cited by 20

Treatment of old mice with IL-2 corrects dysregulated IL-2 and IL-4 production

Kirman, I., Zhao, K., Tschepen, I., Szabo, P., Richter, G. W., Nguyen, H. H., & Wekslzer, M. E. (1996) · International Immunology · doi:10.1093/intimm/8.7.1009 · Cited by 20

Transient Normalization of Lymphocyte Blastogenic and Specific Antibody Responses Following Boosting of Healthy Elderly Subjects With Tetanus Toxoid

Armitage, K., Duffy, E. G., Mincek, M., Miller, C. B., van der Kuyp, F., Horn, D. L., Munger, J. A., Edmonds, K. L., Ferguson, L. S., Rich, E. A., et al. (1993) · Journal of Gerontology · doi:10.1093/geronj/48.1.m19 · Cited by 18

Age-associated changes in lymphoid and antigen-presenting cell functions in mice immunized with Trypanosoma cruzi antigens

Maletto, B. A., Gruppi, A., Morón, G., & Pistoresi-Palencia, M. C. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01719-8 · Cited by 17

Assessment of alloreactive T cell subpopulations of aged mice in vivo. CD4+ but not CD8+ T cell‐mediated rejection response declines with advanced age

Rosenberg, A. S., Sechler, J. M. G., Horvath, J. A., Maniero, T. G., & Bloom, E. T. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240611 · Cited by 17

Influence of age, sex, and dietary restriction on intracellular free calcium responses of CD4+ lymphocytes in rhesus monkeys (Macaca mulatta)

Grossmann, A., Rabinovitch, P. S., Lane, M. A., Jinneman, J. C., Ingram, D. K., Wolf, N. S., Cutler, R. G., & Roth, G. S. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041620216 · Cited by 17

Determinants of survival: An analysis of the effects of age at observation and length of the predictive period

Ljungquist, B., Berg, S., & Steen, B. (1996) · Aging Clinical and Experimental Research · doi:10.1007/bf03340111 · Cited by 17

Evaluation of presence and functional activity of potentially self-reactive T cells in aged mice

Crlsl, G. M., Tsiagbe, V. K., Russo, C., Basch, R. S., & Thorbecke, G. J. (1996) · International Immunology · doi:10.1093/intimm/8.3.387 · Cited by 17

Less death in the dying

Polyák, K., Wu, T., Hamilton, S. R., Kinzler, K. W., & Vogelstein, B. (1997) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400226 · Cited by 17

Age-dependent appearance of non-major histocompatibility complex-restricted helper T cells.

Russo, C., Cherniack, E. P., Wali, A., & Weksler, M. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11718 · Cited by 16

Appearance of isochromosome 18q can be associated with in vitro immortalization of human T lymphocytes

Kaltoft, K., Pedersen, C. B., Hansen, B. H., & Thestrup‐Pedersen, K. (1995) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(94)00192-8 · Cited by 16

Immunology of centenarians

Steinmann, G. G., & Hartwig, M. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80053-0 · Cited by 15

Differential Expression of p53 Tumor Suppressor Protein and IL-2 in Activated T Cells from Elderly Humans

VanAMAN, S. E., & Whisler, R. L. (1998) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1998.18.315 · Cited by 15

Age-related defects in CD2 receptor-induced activation in human T-cell subsets.

Beckman, I., Shepherd, K., Firgaira, F. A., & Ahern, M. J. (1995) · PubMed Central · Cited by 15

Effects of aging on the dynamics of lymphocyte organ distribution in mice: use of a radioiodinated cell membrane probe

Albright, J. W., Mease, R. C., Lambert, C., & Albright, J. F. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00145-0 · Cited by 14

Promotion of interleukin-2 activity as a strategy for ‘rejuvenating’ geriatric immune function

McCarty, M. F. (1997) · Medical Hypotheses · doi:10.1016/s0306-9877(97)90023-2 · Cited by 14

Correlation between the antibody response to influenza vaccine and helper T cell subsets in healthy ageing

Remarque, E. J., Nijhuis, E. W. P., Hinloopen, B., Nagelkerken, L. M., van der Velde, E. A., & Ligthart, G. J. (1996) · Vaccine · doi:10.1016/0264-410x(95)00155-t · Cited by 13

Intracellular free Ca2+ fluxes and responses to phorbol ester in T lymphocytes from healthy elderly subjects

Naylor, J. R., James, S., & Trejdosiewicz, L. K. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb06896.x · Cited by 13

Age-related changes in plasma lipid peroxidation and antioxidant system in humans and rats

Mehmetçik, G., Özdemirler, G., Kanbağlı, Ö., Toker, G. A., & Uysal, M. (1997) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(97)00023-x · Cited by 12

T-lymphocyte proliferative response to mitogen stimulation in elderly depressed patients

Brambilla, F., Maggioni, M., Cenacchi, T., Sacerdote, P., & Panerai, A. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00059-3 · Cited by 10

CD95 Expression in Aged Mice Infected with Tuberculosis

Roberts, A. D., & Orme, I. M. (1998) · Infection and Immunity · doi:10.1128/iai.66.10.5036-5040.1998 · Cited by 9

Age-related events in active T lymphocyte subpopulation. A morphological study

Rana, R., Pietro, R. D., Centurione, L., Vitale, M., Zamai, L., Sciscio, A., & Mazzotti, G. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90034-5 · Cited by 8

Effect of rIL-2 treatment on anti-tetanus toxoid response in the elderly

Fagiolo, U., Bordin, M. C., Biselli, R., D’Amelio, R., Zamarchi, R., & Amadori, A. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01836-2 · Cited by 7

Comparison between serum interleukin-2 concentrations in healthy adult and elderly subjects

Franze, C., Stefano, F. D., Motta, M., Maugeri, D., Stivala, F., Favetta, A., & Carnazzo, G. (1996) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(96)86984-6 · Cited by 6

T Cell Receptor V-Segment Frequencies in Aged Individuals

Ruiz, M., Esparza, B., Barranquero, M., Sabino, É. C., & Merino, F. (1996) · Immunological Investigations · doi:10.3109/08820139609059295 · Cited by 5

Elevated frequency of the C2 allele of the ETS-I oncogene in elderly subjects

Crossen, P. E., & Morrison, M. J. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01721-6 · Cited by 2

B-cell responses to vaccination at the extremes of age

Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567

Activation of Thymic Regeneration in Mice and Humans following Androgen Blockade

Sutherland, J. S., Goldberg, G. L., Hammett, M. V., Uldrich, A. P., Berzins, S. P., Heng, T. S., Blazar, B. R., Millar, J. L., Malin, M. A., Chidgey, A. P., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2741 · Cited by 486

Immunology of aging: the birth of inflammaging

Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., & Franceschi, C. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08899-6 · Cited by 464

Innate immunity and inflammation in ageing: a key for understanding age-related diseases

Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C., & Caruso, C. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-8 · Cited by 453