T cells and aging

Proteasome inactivation upon aging and on oxidation-effect of HSP 90

Conconi, M., & Friguet, B. (1997) · Molecular Biology Reports · doi:10.1023/a:1006852506884 · Cited by 111

Circadian Secretions of IL-2, IL-12, IL-6 and IL-10 in Relation to the Light/Dark Rhythm of the Pineal Hormone Melatonin in Healthy Humans

Lissoni, P., Rovelli, F., Brivio, F., Brivio, O., & Fumagalli, L. A. M. (1998) · Natural Immunity · doi:10.1159/000069464 · Cited by 111

The influence of age on the canine immune system

Greeley, E. H., Kealy, R. D., Ballam, J. M., Lawler, D. F., & Segre, M. (1996) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(96)05563-8 · Cited by 111

Absolute Peripheral Blood Lymphocyte Count and Subsequent Mortality of Elderly Men

Bender, B. S., Nagel, J. E., Adler, W. H., & Andres, R. (1986) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1986.tb04906.x · Cited by 110

The T cell in the ageing individual1This article is based on a presentation to the First International Conference on Aging and Immunology, Bethesda, MD, 16–19 June, 1996.1

Pawelec, G., Adibzadeh, M., Solana, R., & Beckman, I. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01812-x · Cited by 109

Retarding Effect of Dietary Restriction on the Accumulation of 8-Hydroxy-2′-Deoxyguanosine in Organs of Fischer 344 Rats During Aging

Kaneko, T., Tahara, S., & Matsuo, M. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00622-3 · Cited by 108

Endogenous Melatonin Levels and the Fate of Exogenous Melatonin: Age Effects

Zhdanova, I. V., Wurtman, R. J., Balcioglu, A., Kartashov, A. I., & Lynch, H. J. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.4.b293 · Cited by 107

Oligoclonality of CD8 + T cells in health and disease: Aging, infection, or immune regulation?

Batliwalla, F., Monteiro, J., Serrano, D., & Gregersen, P. J. (1996) · Human Immunology · doi:10.1016/0198-8859(96)00077-8 · Cited by 106

The pattern of T lymphocyte differentiation is altered during thymic involution

Thoman, M. L. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01597-s · Cited by 106

Vitamin E Supplementation Decreases Lung Virus Titers in Mice Infected with Influenza

Hayek, M. G., Taylor, S. F., Bender, B. S., Han, S. N., Meydani, M., Smith, D. E., Eghtesada, S., & Meydani, S. N. (1997) · The Journal of Infectious Diseases · doi:10.1086/517265 · Cited by 106

CD4 ligand IL-16 inhibits the mixed lymphocyte reaction

Theodore, A. C., Nicoll, J. M., Fine, G. D., Kornfeld, H., & Cruikshank, W. W. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.5.1958 · Cited by 105

CD7- T cells represent a subset of normal human blood lymphocytes

Reinhold, U., Abken, H., Kukel, S., Moll†, M., Müller, R. H., Oltermann, I., & Kreysel, H. W. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.5.2081 · Cited by 104

Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects

Bogden, J. D., Oleske, J. M., Munves, E. M., Lavenhar, M. A., Bruening, K. S., Kemp, F. W., Holding, K. J., Denny, T. N., & Louria, D. B. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.1.101 · Cited by 102

Bacteremic Urinary Tract Infection in Older People

Ackermann, R. J., & Monroe, P. W. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb01862.x · Cited by 101

High levels of bcl‐2 protein in circulating t lymphocytes, but not b lymphocytes, of patients with systemic lupus erythematosus

Aringer, M., Wintersberger, W., Steiner, C.-W., Kiener, H. P., Presterl, E., Jaeger, U., Smolen, J. S., & Graninger, W. B. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780371004 · Cited by 101

Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast

Peretz, A., Nève, J., Desmedt, J. E., Duchateau, J., Dramaix, M., & Famaey, J. P. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.5.1323 · Cited by 101

Regulation of an extrathymic T-cell development pathway by oncostatin M

Clegg, C. H., Rulffes, J. T., Wallace, P. M., & Haugen, H. S. (1996) · Nature · doi:10.1038/384261a0 · Cited by 99

Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice

Lipman, R. D., Bronson, R. T., Wu, D., Smith, D. E., Prior, R. L., Cao, G., Han, S. N., Martin, K. R., Meydani, S. N., & Meydani, M. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00048-7 · Cited by 99

Investigations of the lymphokine system in elderly individuals

Sindermann, J. R., Kruse, A., Frercks, H.-J., Schütz, R., & Kirchner, H. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90066-z · Cited by 98

Emergence of oligoclonal t cell populations following therapeutic t cell depletion in rheumatoid arthritis

Jendro, M. C., Ganten, T. M., Matteson, E. L., Weyand, C. M., & Goronzy, J. J. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380912 · Cited by 97

Cytokine production by T lymphocytes from young and aged mice

Engwerda, C. R., Fox, B. S., & Handwerger, B. S. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3621 · Cited by 96

Age-Related Reductions in the Activation of Mitogen-Activated Protein Kinases p44mapk/ERK1 and p42mapk/ERK2 in Human T Cells Stimulated via Ligation of the T Cell Receptor Complex

Whisler, R. L., Newhouse, Y. G., & Bagenstose, S. E. (1996) · Cellular Immunology · doi:10.1006/cimm.1996.0067 · Cited by 96

Memory T lymphocyte hyporesponsiveness to non‐cognate stimuli: a key factor in age‐related immunodeficiency

Flurkey, K., Stadecker, M. J., & Miller, R. A. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220408 · Cited by 95

Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia.

Rossi, E., Matutes, E., Morilla, R. M., Owusu-Ankomah, K. A., Am, H., & Catovsky, D. (1996) · PubMed · Cited by 94

Cell-surface-expressed T-cell antigen-receptor zeta chain is associated with the cytoskeleton.

Caplan, S., Reich-Zeliger, S., Wang, L., & Baniyash, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4768 · Cited by 93

ANTITOXIN RESPONSES IN THE ELDERLY TO TETANUS-DIPHTHERIA (TD) IMMUNIZATION

Ruben, F. L., NAGEL, J., & Fireman, P. (1978) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112598 · Cited by 93

Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres.

Kang, M., Guo, W., & Park, N. H. (1998) · PubMed · Cited by 92

Increased apoptosis of CD45RO− T cells with aging

Herndon, F. J., Hsu, H., & Mountz, J. D. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)01882-4 · Cited by 92

Effect of Food Restriction on Life Span and Immune Functions in Long-Lived Fischer-344 × Brown Norway F1 Rats

Fernandes, G., Venkatraman, J. T., Turturro, A., Attwood, V. G., & Hart, R. W. (1997) · Journal of Clinical Immunology · doi:10.1023/a:1027344730553 · Cited by 91

Phenotype of lymphocyte subsets after autologous peripheral blood stem cell transplantation

Koehne, G., Zeller, W., Stockschlaeder, M., & Zander, A. (1997) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1700624 · Cited by 91

Signal transduction for melatonin in human lymphocytes: involvement of a pertussis toxin-sensitive G protein

García‐Pergañeda, A., Pozo, D., Guerrero, J. M., & Calvo, J. R. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.8.3774 · Cited by 90

The expanded null cell compartment in ageing: increase in the number of natural killer cells and changes in T-cell and NK-cell subsets in human blood.

Ligthart, G. J., Pc, V. V., Hr, S., & Hijmans, W. (1986) · PubMed Central · Cited by 90

Effect of ageing on human plasma glutathione concentrations as determined by high-performance liquid chromatography with fluorimetric detection

Yang, C., Chou, S., Liu, L., Tsai, P.-J., & Kuo, J. (1995) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(95)00287-8 · Cited by 89

Dehydroepiandrosterone Sulphate (DHEAS) in the Oldest Old, Aged 85 and Overa

Birkenhäger‐Gillesse, E. G., Derksen, J. J. L., & Lagaay, A. M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb56858.x · Cited by 89

Effect of dietary restriction on in vivo somatic mutation in mice

Dempsey, J. L., Pfeiffer, M. L., & Morley, A. A. (1993) · Mutation Research/Environmental Mutagenesis and Related Subjects · doi:10.1016/0165-1161(93)90153-q · Cited by 88

Life extension and stress resistance in Caenorhabditis elegans. modulated by the tkr-1 gene

Murakami, S., & Johnson, T. E. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70448-8 · Cited by 88

Age Patterns of the Life Table Aging Rate for Major Causes of Death in Japan, 1951-1990

Horiuchi, S., & Wilmoth, J. R. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.1.b67 · Cited by 88

An investigation of mutation as a function of age in humans

King, C. M., Gillespie, E. S., McKenna, P. G., & Barnett, Y. (1994) · Mutation Research/DNAging · doi:10.1016/0921-8734(94)90010-8 · Cited by 87

Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents

Castle, S. C., Uyemura, K., Wong, W. B., Modlin, R. L., & Effros, R. B. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01821-0 · Cited by 87

Dysregulation of IL-10 production with aging: Possible linkage to the age-associated decline in DHEA and its sulfated derivative

SPENCER, N. F. L., Norton, S. D., Harrison, L. L., Li, G., & Daynes, R. A. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(95)02033-0 · Cited by 86

Chagasic Patients Lack CD28 Expression on Many of Their Circulating T Lymphocytes

Dutra, W. O., Martins‐Filho, O. A., Cançado, J. R., PINTO‐DIAS, J. C., Brener, Z., Gazzinelli, G., Carvalho-Parra, J. F., & Colley, D. G. (1996) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1996.d01-9.x · Cited by 86

Suppression of apoptosis by Bcl-2 or Bcl-xL promotes susceptibility to mutagenesis.

Cherbonnel, C., Gauny, S. S., & Kronenberg, A. (1996) · PubMed · Cited by 86

Age‐Related Decline in Interleukin 2 Production in Response to Influenza Vaccine

McElhaney, J. E., Beattie, B. L., Devine, R. D. O., Grynoch, R., Toth, E. L., & Bleackley, R. C. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb01424.x · Cited by 85

Age-associated changes in human T cell phenotype and function

Jackola, D. R., Ruger, J. K., & Miller, R. A. (1994) · Aging Clinical and Experimental Research · doi:10.1007/bf03324210 · Cited by 85

Cytokine Antagonists in Aged Subjects and Their Relation With Cellular Immunity

Catania, A. P., Airaghi, L., Motta, P., Manfredi, M. G., Annoni, G., Pettenati, C., Brambilla, F., & Lipton, J. M. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.2.b93 · Cited by 85

Differential effects of gastrin-releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1β, interleukin-6 and tumor necrosis factor-α production by whole blood cells from healthy young and old subjects

Hernánz, Á., Tato, E., la Fuente, M. D., de Miguel, E., & Arnalich, F. (1996) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00118-x · Cited by 83

Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors

Phelouzat, M.-A., Laforge, T., Arbogast, A., Quadri, R. A., Boutet, S. C., & Proust, J. J. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)01883-6 · Cited by 83

The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis1This work was supported by National Institutes of Health Grant AG00424.1

Spaulding, C. C., Walford, R. L., & Effros, R. B. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01808-8 · Cited by 82

Immunodeficiency of Aging

Burns, E. A., & Goodwin, J. S. (1997) · Drugs & Aging · doi:10.2165/00002512-199711050-00005 · Cited by 82

Cell division in the compartment of naive and memory T lymphocytes

Bruno, L., von Boehmer, H., & Kirberg, J. (1996) · European Journal of Immunology · doi:10.1002/eji.1830261251 · Cited by 82

Dehydroepiandrosterone (DHEA) treatment reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection

Danenberg, H. D., Ben-Yehuda, A., Zakay‐Rones, Z., & Friedman, G. (1995) · Vaccine · doi:10.1016/0264-410x(95)00063-7 · Cited by 80

Control of fibroblast senescence and activation of programmed cell death

Wang, E., Lee, M., & Pandey, S. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240540410 · Cited by 78

Restoration of the Thymus in Aging Mice by in Vivo Zinc Supplementation

Dardenne, M., Boukaïba, N., Gagnerault, M. C., Homo‐Delarche, F., Chappuis, P., Lemonnier, D., & Savino, W. (1993) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1993.1016 · Cited by 78

Evidence for Lowered Induction of Nuclear Factor Kappa B in Activated Human T Lymphocytes during Aging

Trebilcock, G. U., & Ponnappan, U. (2009) · Gerontology · doi:10.1159/000213785 · Cited by 78

Numerical and Functional Characteristics of Lymphocyte Subsets in Centenarians

Miyaji, C., Watanabe, H., Minagawa, M., Toma, H., Kawamura, T., Nohara, Y., Nozaki, H., Sato, Y., & Abo, T. (1997) · Journal of Clinical Immunology · doi:10.1023/a:1027324626199 · Cited by 77

Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence

Phelouzat, M.-A., Arbogast, A., Laforge, T., Quadri, R. A., & Proust, J. J. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01714-9 · Cited by 77

Expanded CD4+CD45RO+ phenotype and defective proliferative response in T lymphocytes from patients with Crohn's disease

Roman, L. I., Manzano, L., de la Hera, A., Abreu, L., Rossi, I., & Álvarez‐Mon, M. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8612987 · Cited by 77

Age-related changes in T cell surface markers: a longitudinal analysis in genetically heterogeneous mice

Miller, R. A. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)01893-9 · Cited by 76

Exercise, immunity and aging

Venkatraman, J. T., & Fernandes, G. (1997) · Aging Clinical and Experimental Research · doi:10.1007/bf03340127 · Cited by 75

T cell cultures and the Hayflick limit

Effros, R. B., & Walford, R. L. (1984) · Human Immunology · doi:10.1016/0198-8859(84)90006-5 · Cited by 74

Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis

Mariani, E., Roda, P., Mariani, A. R., Vitale, M., Degrassi, A., Papa, S., & Facchini, A. (1990) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1990.tb05359.x · Cited by 74

Tissue-specific distribution and age-dependent increase of human CD11b+ T cells.

Hoshino, T., Yamada, A., Honda, J., et al. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.4.2237 · Cited by 73

Immunosenescence in HIV Pathogenesis

Pommier, J., Gauthier, L., Livartowski, J., Galanaud, P., Boué, F., Dulioust, A., Marcé, D., Ducray, C., Sabatier, L., Lebeau, J., et al. (1997) · Virology · doi:10.1006/viro.1997.8512 · Cited by 73

Sex and parity modulate cytokine production during murine ageing

Barrat, F., Lesourd, B., BOULOUIS, H.-J., Thibault, D., Vincent-Naulleau, S. S., Gjata, B., LOUISE, A., Neway, T., & PILET, C. H. (1997) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1997.4851387.x · Cited by 73

Nutrition and Immunoregulation. Significance for Host Resistance to Tumors and Infectious Diseases in Humans and Rodents

Chandra, R. K. (1992) · Journal of Nutrition · doi:10.1093/jn/122.suppl_3.754 · Cited by 72

Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1

Tugores, A., Alonso, M. A., Sánchez‐Madrid, F., & Landázuri, M. O. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2300 · Cited by 72

A comprehensive analysis of peripheral blood lymphocytes in healthy aged humans by flow cytometry

XU, X., Beckman, I., Ahern, M. J., & Bradley, J. (1993) · Immunology and Cell Biology · doi:10.1038/icb.1993.61 · Cited by 72

In vivo T cell activation, in vitro defective IL-2 secretion, and response to influenza vaccination in elderly women

Huang, Y.-P., Pechère, J. C., Michel, M., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.3.715 · Cited by 71

Age-Related Changes in the Peroxyl Radical Scavenging Capacity of Human Plasma

Aejmelaeus, R., Holm, P., Kaukinen, U., Metsä‐Ketelä, T., Laippala, P. J., Hervonen, A., & Alho, H. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00591-6 · Cited by 71

Stress Response of Senescent T Lymphocytes Reduced hsp70 Is Independent of the Proliferative Block

Effros, R. B., Zhu, X., & Walford, R. L. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.b65 · Cited by 71

Cytokine production and aging: overproduction of IL-8 in elderly males in response to lipopolysaccharide

Clark, J. A., & Peterson, T. C. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90020-5 · Cited by 70

Large-scale expansion in interleukin-2 of tumor-infiltrating lymphocytes from patients with ovarian carcinoma for adoptive immunotherapy

Freedman, R. S., Tomasovic, B., Templin, S., Atkinson, E. N., Kudelka, A. P., Edwards, C. L., & Platsoucas, C. D. (1994) · Journal of Immunological Methods · doi:10.1016/0022-1759(94)90084-1 · Cited by 70

Age and gender dependent levels of glutathione and glutathione S- transferases in human lymphocytes

van Lieshout, E. (1998) · Carcinogenesis · doi:10.1093/carcin/19.10.1873 · Cited by 70

Cutting Edge: Antigen-Dependent Regulation of Telomerase Activity in Murine T Cells

Hathcock, K. S., Weng, N., Merica, R. R., Jenkins, M. K., & Hodes, R. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.12.5702 · Cited by 69

Decreased Immunity and Increased Morbidity in the Elderly

Goodwin, J. S. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1995.tb01515.x · Cited by 69

Interleukin 2, interleukin 2 receptor, and interferon-γ synthesis and mRNA expression in phorbol myristate acetate and calcium lonophore A23187-stimulated T cells from elderly humans

Chopra, R. K., Holbrook, N. J., Powers, D. C., McCoy, M. T., Adler, W. H., & Nagel, J. E. (1989) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(89)90058-5 · Cited by 69

Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human cd4+ tcr2+ cultured T cell clones

Pawelec, G., Sansom, D., Rehbein, A., Adibzadeh, M., & Beckman, I. (1996) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00097-6 · Cited by 68

In vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75- to 80-year-old humans

King, C. M., Bristow-Craig, H. E., Gillespie, E. S., & Barnett, Y. A. (1997) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00072-9 · Cited by 68

Antibody response to whole-virus and split-virus influenza vaccines in successful ageing

McElhaney, J. E., Meneilly, G. S., Lechelt, K. E., Beattie, B. L., & Bleackley, R. C. (1993) · Vaccine · doi:10.1016/0264-410x(93)90133-i · Cited by 68

Effect of age on lymphocyte proliferation

McCarron, M., Osborne, Y., Story, C. J., Dempsey, J. L., Turner, D. R., & Morley, A. A. (1987) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(87)90041-8 · Cited by 68

Cytokine production in varicella zoster virus-stimulated limiting dilution lymphocyte cultures

Zhang, Y., Cosyns, M., Levin, M. J., & Hayward, A. R. (1994) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1994.tb06618.x · Cited by 68

Changes in Telomerase Activity and Telomere Length during Human T Lymphocyte Senescence

Pan, C.-X., Xue, B.-H., Ellis, T. M., Peace, D. J., & Díaz, M. O. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3475 · Cited by 68

CD4 memory T cell levels predict life span in genetically heterogeneous mice

Miller, R. A., Chrisp, C. E., & Gałecki, A. T. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.10.9271362 · Cited by 67

A functional link for major TCR expansions in healthy adults caused by persistent Epstein-Barr virus infection.

Silins, S. L., Cross, S., Krauer, K. G., Moss, D. J., Schmidt, C., & MISKO, I. S. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4225 · Cited by 66

Alterations in sympathetic innervation of thymus and spleen in aged mice

Madden, K. S., Bellinger, D. L., Felten, S. Y., et al. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01858-1 · Cited by 66

Differential Tyrosine Phosphorylation of Zeta Chain Dimers in Mouse CD4 T Lymphocytes: Effect of Age

Garcia, G. G., & Miller, R. A. (1997) · Cellular Immunology · doi:10.1006/cimm.1996.1040 · Cited by 65

Changes in Lymphocyte Subsets and Immune Competence in Very Advanced Age

Lehtonen, L., Eskola, J., Vainio, O., & Lehtonen, A. O. (1990) · Journal of Gerontology · doi:10.1093/geronj/45.3.m108 · Cited by 65

Long-term culture of monoclonal human T lymphocytes: models for immunosenescence?

Adibzadeh, M., Pohla, H., Rehbein, A., & Pawelec, G. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01625-a · Cited by 64

Effect of melatonin and pineal grafting on thymocyte apoptosis in aging mice

Provinciali, M., Stefano, G. D., Bulian, D., Tibaldi, A., & Fabris, N. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01746-0 · Cited by 64

Age‐related increase of CD45RO+ lymphocytes in physically active adults

Gabriel, H. H. W., Schmitt, B. A., & Kindermann, W. (1993) · European Journal of Immunology · doi:10.1002/eji.1830231049 · Cited by 64

Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death

Boussiotis, V. A., Lee, B. J., Freeman, G. J., Gribben, J. G., & Nadler, L. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.7.3156 · Cited by 63

Diminished heat-shock protein synthesis following mitogen stimulation of lymphocytes from aged donors

Faassen, A. E., O’Leary, J. J., Rodysill, K. J., Bergh, N., & Hallgren, H. M. (1989) · Experimental Cell Research · doi:10.1016/0014-4827(89)90393-5 · Cited by 63

The Decline of Cell-mediated Immunity in Aging Mice

Menon, M., Jaroslow, B. N., & Koesterer, R. (1974) · Journal of Gerontology · doi:10.1093/geronj/29.5.499 · Cited by 63

The in vitro senescence of human T lymphocytes: Failure to divide is not associated with a loss of cytolytic activity or memory T cell phenotype

Perillo, N. L., Naeim, F., Walford, R. L., & Effros, R. B. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90121-7 · Cited by 63

CD57+/CD28− T cells in untreated hemato-oncological patients are expanded and display a Th1-type cytokine secretion profile, ex vivo cytolytic activity and enhanced tendency to apoptosis

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Supplementation with Selenium Restores Age-Related Decline in Immune Cell Function

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Is the Phenotypic Combination A1B8Cw7DR3 a Marker for Male Longevity?

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Functional disability and antibody response to influenza vaccine in elderly patients in a Dutch nursing home: Table 1

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Oxidative stress suppresses transcription factor activities in stimulated lymphocytes

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Reduced Activation of Transcriptional Factor AP-1 among Peripheral Blood T Cells from Elderly Humans after PHA Stimulation: Restorative Effect of Phorbol Diesters

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Idiosyncratic Alterations of TCR Size Distributions Affecting Both CD4 and CD8 T Cell Subsets in Aging Mice

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Human lymphocyte telomerase is genetically regulated

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Relevance of oxidative stress to the limited replicative capacity of cultured human diploid cells: the limit of cumulative population doublings increases under low concentrations of oxygen and decreases in response to aminotriazole

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IL-4-responsive human helper T cell clones are resistant to growth inhibition by tumor necrosis factor-alpha.

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In vitro T cell activation in elderly individuals: failure in CD69 and CD71 expression

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HPRT mutant T cells in the peripheral blood and synovial tissue of patients with rheumatoid arthritis

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Differential expression of the α- and β-isoforms of protein kinase C in peripheral blood T and B cells from young and elderly adults

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Activation of Murine T-cells via Phospholipase-C l-Associated Protein Tyrosine Phosphorylation Is Reduced With Aging

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Quantitative and qualitative analysis of anti-tetanus toxoid antibody response in the elderly. Humoral immune response enhancement by thymostimulin

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Induction and repair of benzo[a]pyrene-DNA adducts in C57BL/6 and BALB/c mice: association with aging and longevity

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Aged-Rodent Models of Long-Term Growth Hormone Therapy: Lack of Deleterious Effect on Longevity

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CD11b+CD28-CD4+ human T cells: activation requirements and association with HLA-DR alleles

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Differential Expression of Various T Cell Surface Markers in Young and Elderly Subjects

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Feedback regulation of T cell development: manifestations in aging

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Lymphocyte content of amyloid precursor protein is increased in Down's syndrome and aging

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Decreased maturation of T-cell populations in the healthy elderly: Influence of nutritional factors on the appearance of double negative CD4-, CD8-, CD2+ cells

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The age-associated decline in immune function of healthy individuals is not related to changes in plasma concentrations of β-carotene, retinol, α-tocopherol or zinc

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HLA‐B8,DR3 PHENOTYPE AND LYMPHOCYTE RESPONSES TO PHYTOHAEMAGGLUTININ

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Influence of Genes Associated with the Main Histocompatibility Complex on Deoxyribonucleic Acid Excision Repair Capacity and Bleomycin Sensitivity in Mouse Lymphocytes

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Phytohemagglutinin induced proliferation by aged lymphocytes: Reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion

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Thymocyte progenitors and T cell development in aging

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Age-related enhancement of tumor necrosis factor (TNF) production in mice

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B-cell responses to vaccination at the extremes of age

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Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

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Activation of Thymic Regeneration in Mice and Humans following Androgen Blockade

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Immunology of aging: the birth of inflammaging

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Innate immunity and inflammation in ageing: a key for understanding age-related diseases

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