Targeting HMGB1 TLR4 signaling as a novel approach to treatment of cerebral ischemia
Open accessAbstract
HMGB1 is a ubiquitous, highly conserved DNA-binding protein with well-established functions in the maintenance of nuclear homeostasis. Much of the recent work about its signaling functions in the brain has focused on its proinflammatory properties and relationship to known inflammatory receptors such as toll-like receptor 4 (TLR4). HMGB1 is massively released into the extracellular space immediately after ischemic insult and that it subsequently induces neuroinflammation in the postischemic brain, indicating that HMGB1 acts as a novel mediator in cerebral ischemic injury. Consistently, numerous reports point to TLR4 as a pivotal player in the ischemic brain. The use of HMGB1 and TLR4 ligand as preconditioning stimulus may be benefit of the outcome of cerebral ischemia. Therefore, this review presents the latest findings supporting the involvement of HMGB1 and TLR4 in cerebral ischemia. Targeting HMGB1/TLR4 signaling may provide a novel therapeutic approach for clinical prevention of cerebral ischemic injury.
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HMGB1 has a pivotal role in the induction of neuroinflammatory processes in neurodegenerative conditions, cerebral ischemia, traumatic brain injury, seizure, and ethanol-induced neurotoxicity.
“HMGB1 has a pivotal role in the induction of neuroinflammatory processes in neurodegenerative conditions (Fang et al, 2012), cerebral ischemia (Yang et al, 2010), traumatic brain injury (Corps et al, 2015), seizure (Vezzani, 2014), and ethanolinduced neurotoxicity (Zou and Crews, 2014).”
From Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders (2017) · cites this paper as Yang et al, 2010
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- Authors
- Yang, Q.-W.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2010
- Volume
- S2
- Issue
- 3
- Pages
- 1081-1091
- ISSN
- 1944-7906 (ISSN-L)
- 1945-0516
- 1945-0524
- DOI
- 10.2741/s119
- OpenAlex
- W2082857889
- Cited by
- 55
- References
- 79
- Citations by year
- 2026: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 5
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in Bioscience-Scholar (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30870859, 2008BB5279)
- Chongqing Science and Technology Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- HMGB1, TLR4, cerebral ischemia, neuroinflammation, ischemic brain injury, preconditioning, extracellular HMGB1 release, neuroprotection
- MeSH terms
- Animals, Antibodies, Monoclonal, Brain, Brain Ischemia, Humans, Ligands, Models, Neurological, Signal Transduction, Ischemic Preconditioning, HMGB1 Protein, Toll-Like Receptor 4
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