Cited by 55Advanced Glycation End Products researchNeuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

Targeting HMGB1 TLR4 signaling as a novel approach to treatment of cerebral ischemia

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Yang, Qing-Wu·2010·Frontiers in Bioscience

Abstract

HMGB1 is a ubiquitous, highly conserved DNA-binding protein with well-established functions in the maintenance of nuclear homeostasis. Much of the recent work about its signaling functions in the brain has focused on its proinflammatory properties and relationship to known inflammatory receptors such as toll-like receptor 4 (TLR4). HMGB1 is massively released into the extracellular space immediately after ischemic insult and that it subsequently induces neuroinflammation in the postischemic brain, indicating that HMGB1 acts as a novel mediator in cerebral ischemic injury. Consistently, numerous reports point to TLR4 as a pivotal player in the ischemic brain. The use of HMGB1 and TLR4 ligand as preconditioning stimulus may be benefit of the outcome of cerebral ischemia. Therefore, this review presents the latest findings supporting the involvement of HMGB1 and TLR4 in cerebral ischemia. Targeting HMGB1/TLR4 signaling may provide a novel therapeutic approach for clinical prevention of cerebral ischemic injury.

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  • HMGB1 has a pivotal role in the induction of neuroinflammatory processes in neurodegenerative conditions, cerebral ischemia, traumatic brain injury, seizure, and ethanol-induced neurotoxicity.

    “HMGB1 has a pivotal role in the induction of neuroinflammatory processes in neurodegenerative conditions (Fang et al, 2012), cerebral ischemia (Yang et al, 2010), traumatic brain injury (Corps et al, 2015), seizure (Vezzani, 2014), and ethanolinduced neurotoxicity (Zou and Crews, 2014).”

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Authors
Yang, Q.-W.
Venue
Frontiers in Bioscience
Publisher
IMR Press
Published
2010
Volume
S2
Issue
3
Pages
1081-1091
ISSN
  • 1944-7906 (ISSN-L)
  • 1945-0516
  • 1945-0524
OpenAlex
W2082857889
Cited by
55
References
79
Citations by year
2026: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 5
FWCI
0.49
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Bioscience-Scholar (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (30870859, 2008BB5279)
  • Chongqing Science and Technology Commission
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
HMGB1, TLR4, cerebral ischemia, neuroinflammation, ischemic brain injury, preconditioning, extracellular HMGB1 release, neuroprotection
MeSH terms
Animals, Antibodies, Monoclonal, Brain, Brain Ischemia, Humans, Ligands, Models, Neurological, Signal Transduction, Ischemic Preconditioning, HMGB1 Protein, Toll-Like Receptor 4

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