Comparison of diagnostic clinical samples and environmental sampling for enterovirus and parechovirus surveillance in Scotland, 2010 to 2012
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Human enteroviruses (EV) and parechoviruses (HPeV) within the family Picornaviridae are the most common causes of viral central nervous system (CNS)-associated infections including meningitis and neonatal sepsis-like disease. The frequencies of EV and HPeV types identified in clinical specimens collected in Scotland over an eight-year period were compared to those identified in sewage surveillance established in Edinburgh. Of the 35 different EV types belonging to four EV species (A to D) and the four HPeV types detected in this study, HPeV3 was identified as the most prevalent picornavirus in cerebrospinal fluid samples, followed by species B EV. Interestingly, over half of EV and all HPeV CNS-associated infections were observed in young infants (younger than three months). Detection of species A EV including coxsackievirus A6 and EV71 in clinical samples and sewage indicates that these viruses are already widely circulating in Scotland. Furthermore, species C EV were frequently identified EV in sewage screening but they were not present in any of 606 EV-positive clinical samples studied, indicating their likely lower pathogenicity. Picornavirus surveillance is important not only for monitoring the changing epidemiology of these infections but also for the rapid identification of spread of emerging EV and/or HPeV types.
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EV71 was not detected in this cohort.
“We did not detect EV71 although this strain is reported to circulate in different European countries [18, 19].”
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- Authors
- Harvala, H., Calvert, J., Van Nguyen, D., Clasper, L., Gadsby, N., Molyneaux, P., Templeton, K., McWilliams Leitch, C., & Simmonds, P.
- Affiliations
- Roslin Institute (GB)
- Infection and Immunity, Roslin Institute, University of Edinburgh, Edinburgh United Kingdom
- Edinburgh Royal Infirmary (GB)
- Aberdeen Royal Infirmary (GB)
- Specialist Virology Centre, Royal Infirmary Edinburgh, Edinburgh United Kingdom
- Venue
- Eurosurveillance
- Published
- 2014-04-17
- Volume
- 19
- Issue
- 15
- ISSN
- 1025-496X (ISSN-L)
- 1560-7917
- OpenAlex
- W1998722903
- Cited by
- 87
- References
- 26
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 2 · 2019: 9 · 2018: 17 · 2017: 13 · 2016: 11 · 2015: 9 · 2014: 2
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eurosurveillance (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- human enteroviruses, cerebrospinal fluid, wastewater surveillance, viral surveillance, meningitis, infant infection, coxsackievirus A6, enterovirus 70, Scotland
- MeSH terms
- Central Nervous System Infections, Cerebrospinal Fluid, Enterovirus, Feces, United Kingdom, Humans, Phylogeny, Picornaviridae Infections, RNA, Viral, Scotland, Serotyping, Sewage, Specimen Handling, Prevalence, Sequence Analysis, DNA, Sentinel Surveillance, Sepsis, Reverse Transcriptase Polymerase Chain Reaction, Parechovirus
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