Magnetic tagging of therapeutic cells for MRI
Open accessAbstract
Transplantation of stem cells or immune cells has shown promise for the treatment of several diseases. Monitoring magnetically labeled cells with MRI has furthered our understanding of cellular migration and the pathophysiology of diseases in experimental models. These studies should pave the way for guiding clinical trials using cell-based therapies. This review briefly describes the various methods used to label and track cells with MRI and the potential for such methods to translate to human applications.
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Stem cells as well as immune cells such as T cells and dendritic cells have been labeled with SPION to allow for noninvasive tracking via MR imaging and to monitor in vivo delivery to the site of action.
“In this context, stem cells as well as immune cells such as T cells [259] and dendritic cells [126] have been labeled with SPION to allow for noninvasive tracking via MR imaging and to monitor in vivo delivery to the site of action [260].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [260]
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de Vries, I. J. M., Lesterhuis, W. J., Barentsz, J. O., Verdijk, P., van Krieken, J. H., Boerman, O. C., Oyen, W. J. G., Bonenkamp, J. J., Boezeman, J. B., Adema, G. J., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1154 · Cited by 821 · see citing works
In vivo imaging platform for tracking immunotherapeutic cells
Ahrens, E. T., Flores, R. R., Xu, H., & Morel, P. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1121 · Cited by 620 · see citing works
Dynamic Imaging of Allogeneic Mesenchymal Stem Cells Trafficking to Myocardial Infarction
Kraitchman, D. L., Tatsumi, M., Gilson, W. D., Ishimori, T., Kedziorek, D., Walczak, P., Segars, W. P., Chen, H. H., Fritzges, D., Izbudak, I., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.537480 · Cited by 602 · see citing works
A new transgene reporter for in vivo magnetic resonance imaging
Genové, G., DeMarco, U., Xu, H., Goins, W. F., & Ahrens, E. T. (2005) · Nature Medicine · doi:10.1038/nm1208 · Cited by 423 · see citing works
Walczak, P., Zhang, J., Gilad, A. A., Kedziorek, D., Ruı́z-Cabello, J., Young, R. G., Pittenger, M. F., van Zijl, P. C. M., Huang, J., & Bulte, J. W. M. (2008) · Stroke · doi:10.1161/strokeaha.107.502047 · Cited by 405 · see citing works
Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles
Cunningham, C. H., Arai, T., Yang, P. C.-M., McConnell, M. V., Pauly, J. M., & Conolly, S. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20477 · Cited by 403 · see citing works
Artificial reporter gene providing MRI contrast based on proton exchange
Gilad, A. A., McMahon, M. T., Walczak, P., Winnard, P. T., Raman, V., van Laarhoven, H. W. M., Skoglund, C. M., Bulte, J. W. M., & van Zijl, P. C. M. (2007) · Nature Biotechnology · doi:10.1038/nbt1277 · Cited by 387 · see citing works
In vivo detection of single cells by MRI
Shapiro, E. M., Sharer, K., Skrtic, S., & Koretsky, A. P. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20718 · Cited by 378 · see citing works
Universal cell labelling with anionic magnetic nanoparticles
Wilhelm, C., & Gazeau, F. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.016 · Cited by 344 · see citing works
Guzman, R., Uchida, N., Bliss, T., He, D., Christopherson, K. K., Stellwagen, D., Capela, A., Greve, J., Malenka, R., Moseley, M., et al. (2007) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0608519104 · Cited by 336 · see citing works
Partlow, K. C., Chen, J., Brant, J. A., Neubauer, A. M., Meyerrose, T. E., Creer, M. H., Nolta, J. A., Caruthers, S. D., Lanza, G. M., & Wicldine, S. A. (2007) · The FASEB Journal · doi:10.1096/fj.06-6505com · Cited by 306 · see citing works
Arbab, A. S., Yocum, G. T., Rad, A. M., Khakoo, A. Y., Fellowes, V., Read, E. J., & Frank, J. A. (2005) · NMR in Biomedicine · doi:10.1002/nbm.991 · Cited by 297 · see citing works
Self-citationModo, M., Hoehn, M., & Bulte, J. W. M. (2005) · Molecular Imaging · doi:10.1162/15353500200505145 · Cited by 296 · see citing works
Tracking Neural Stem Cells in Patients with Brain Trauma
Zhu, J., Zhou, L., & XingWu, F. (2006) · New England Journal of Medicine · doi:10.1056/nejmc055304 · Cited by 291 · see citing works
Heyn, C., Ronald, J. A., Ramadan, S. S., Snir, J. A., Barry, A. M., MacKenzie, L. T., Mikulis, D. J., Palmieri, D., Bronder, J. L., Steeg, P. S., et al. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21029 · Cited by 291 · see citing works
Modo, M., Mellodew, K., Cash, D., et al. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.08.030 · Cited by 263 · see citing works
Clinical Magnetic Resonance Imaging of Pancreatic Islet Grafts After Iron Nanoparticle Labeling
Toso, C., Vallée, J., Morel, P., Ris, F., Demuylder-Mischler, S., Lepetit‐Coiffé, M., Marangon, N., Saudek, F., Shapiro, A. M. J., Bosco, D., et al. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.02120.x · Cited by 263 · see citing works
Anderson, S. A., Glod, J. W., Arbab, A. S., Noel, M., Ashari, P., Fine, H. A., & Frank, J. A. (2004) · Blood · doi:10.1182/blood-2004-06-2222 · Cited by 254 · see citing works
Self-citationIn vivo imaging of islet transplantation
Evgenov, N. V., Medarova, Z. O., Dai, G., Bonner‐Weir, S., & Moore, A. V. (2005) · Nature Medicine · doi:10.1038/nm1316 · Cited by 250 · see citing works
Wu, Y. L., Ye, Q., Foley, L. M., Hitchens, T. K., Sato, K., Williams, J. B., & Ho, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507198103 · Cited by 200 · see citing works
MRI detection of transcriptional regulation of gene expression in transgenic mice
Cohen, B., Ziv, K., Plaks, V., Israely, T., Kalchenko, V., Harmelin, A., Benjamin, L. E., & Neeman, M. (2007) · Nature Medicine · doi:10.1038/nm1497 · Cited by 194 · see citing works
Zurkiya, O., Chan, A. W. S., & Hu, X. P. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21606 · Cited by 181 · see citing works
Terreno, E., Crich, S. G., Belfiore, S., et al. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20793 · Cited by 170 · see citing works
In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets
Evgenov, N. V., Medarova, Z. O., Pratt, J., Pantazopoulos, P., Leyting, S., Bonner‐Weir, S., & Moore, A. V. (2006) · Diabetes · doi:10.2337/db06-0484 · Cited by 160 · see citing works
Callera, F., & de Melo, C. M. T. P. (2007) · Stem Cells and Development · doi:10.1089/scd.2007.0083 · Cited by 139 · see citing works
Gadolinium-Fullerenol as a Paramagnetic Contrast Agent for Cellular Imaging
Anderson, S. A., Lee, K. K., & Frank, J. A. (2006) · Investigative Radiology · doi:10.1097/01.rli.0000192420.94038.9e · Cited by 122 · see citing works
Self-citationPawelczyk, E., Arbab, A. S., Pandit, S., Hu, E. S., & Frank, J. A. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1038 · Cited by 120 · see citing works
Self-citationPawelczyk, E., Arbab, A. S., Chaudhry, A., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0707 · Cited by 116 · see citing works
Cellular MRI and its Role in Stem Cell Therapy
Arbab, A. S., & Frank, J. A. (2008) · Regenerative Medicine · doi:10.2217/17460751.3.2.199 · Cited by 77 · see citing works
Self-citationLiu, W., Dahnke, H., Jordan, E. K., et al. (2007) · NMR in Biomedicine · doi:10.1002/nbm.1187 · Cited by 72 · see citing works
The in vitro effects of a bimodal contrast agent on cellular functions and relaxometry
Brekke, C., Morgan, S. C., Lowe, A., et al. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1077 · Cited by 63 · see citing works
Cellular Magnetic Resonance Imaging: In Vivo Imaging of Melanoma Cells in Lymph Nodes of Mice
Foster, P. J., Dunn, E. A., Karl, K. E., Snir, J. A., Nycz, C. M., Harvey, A., & Pettis, R. J. (2008) · Neoplasia · doi:10.1593/neo.07937 · Cited by 60 · see citing works
Imaging in cardiac cell-based therapy: in vivo tracking of the biological fate of therapeutic cells
Ly, H. Q., Frangioni, J. V., & Hajjar, R. J. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1159 · Cited by 31 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [28]Guzman R Uchida N Bliss TM Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI Proc Natl Acad Sci U S A Jun 12 2007 104 24 10211 10216 17553967 PMC1891235
- [32]de Vries IJ Lesterhuis WJ Barentsz JO Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy Nat Biotechnol 2005 23 1407 1413 16258544
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Applications and potential toxicity of magnetic iron oxide nanoparticles
Liu, G., Gao, J., Ai, H., & Chen, X. (2013) · Small · doi:10.1002/smll.201201531 · Cited by 570 · see citing works
- Authors
- Budde, M. D., & Frank, J. A.
- Affiliations
- National Institutes of Health (US)
- Venue
- Journal of Nuclear Medicine
- Publisher
- Society of Nuclear Medicine
- Published
- 2009-01-21
- Volume
- 50
- Issue
- 2
- Pages
- 171-174
- ISSN
- 0161-5505 (ISSN-L)
- 2159-662X
- PMC
- PMC2633027
- OpenAlex
- W2142244326
- Cited by
- 78
- References
- 33
- Citations by year
- 2021: 4 · 2020: 7 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 9 · 2012: 9
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Nuclear Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- NIH Clinical Center (Z01CL090007)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- magnetic cell labeling, MRI cell tracking, cell transplantation, stem cell transplantation, cell therapy, cell migration
- MeSH terms
- Animals, Contrast Media, Ferric Compounds, Fluorocarbons, Gadolinium, Humans, Immune System, Magnetic Resonance Imaging, Magnetics, Genes, Reporter, Transplants, Stem Cell Transplantation, Metal Nanoparticles
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