The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Oxygen Free Radicals and Brain Dysfunction
Abstract
Oxygen free radicals, any chemical moiety containing an oxygen atom with an unpaired electron in the outer orbital shell, are generated during many normal biochemical reactions in living tissue. The unpaired electron makes these compounds highly reactive and they can initiate disruptive peroxidation reactions with various substrates important to the survival of cells such as proteins, lipids and nucleic acids. A fairly complex defense system has evolved to protect living tissue from free radicals and to minimize the damage they might cause. Neurons are especially vulnerable to free radical attack and impaired defenses or exposure to excess free radicals can lead to neuronal death. Free radicals contribute to neuronal loss in cerebral ischemia and hemorrhage and may be involved in the degeneration of neurons in epilepsy, schizophrenia, tardive dyskinesia, normal aging, Parkinson's Disease and Alzheimer's Disease. The development of drugs that limit or prevent the attack of free radicals on neurons would be an important advance in the treatment of these conditions.
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Cites
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Cited by
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
Fahn, S., & Cohen, G. (1992) · Annals of Neurology · doi:10.1002/ana.410320616 · Cited by 927
Mattson, M. P., Goodman, Y., Luo, H., Fu, W., & Furukawa, K. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970915)49:6<681::aid-jnr3>3.0.co;2-3 · Cited by 567
Oxidative stress, inflammation and treatment response in major depression
Lindqvist, D., Dhabhar, F. S., James, S. J., Hough, C. M., Jain, F. A., Bersani, F. S., Reus, V. I., Verhoeven, J. E., Epel, E. S., Mahan, L., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.031 · Cited by 473
Antioxidant enzyme activities and oxidative stress in affective disorders
Erkan Ozcan, M., Gulec, M., Ozerol, E., Polat, R., & Akyol, O. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00006 · Cited by 368
Metadata
- Authors
- Jesberger, J. A., & Richardson, J. S.
- Venue
- International Journal of Neuroscience
- Publisher
- Informa UK Limited
- Published
- 1991-01
- Volume
- 57
- Issue
- 1-2
- Pages
- 1-17
- ISSN
- 0020-7454 (ISSN-L)
- 1543-5245
- OpenAlex
- W2030720135
- Cited by
- 273
- References
- 84
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jesberger, J. A., & Richardson, J. S. (1991). Oxygen Free Radicals and Brain Dysfunction. International Journal of Neuroscience. https://doi.org/10.3109/00207459109150342
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
