The relationships between high-sensitivity C-reactive protein and incident depressed mood among older adults
Abstract
Abstract Background. High levels of high-sensitivity C-reactive protein (hs-CRP) are associated with depressed mood, but the causal relationships are not known. Therefore, we examined the relationships between hs-CRP and incident depressed mood among the elderly. Methods. Altogether 764 (69%) individuals out of a representative sample of subjects aged 70 years or older (N = 1113) were screened with the Short Zung Self Rating Depression Scale (SZSRDS), and serum hs-CRP determinations were done at the same time. After a two-and-a-half-year follow-up, the SZSRDS examinations were repeated among those who were free of depressed mood (SZSRDS score >or=28 or use of an anti-depressant drug) at the baseline (N = 404). Analysis of covariance (ANCOVA) and logistic regression were used to analyse the relationship between the baseline hs-CRP (<1, 1 < 3, 3 <10 mg/L) and the follow-up SZSRDS scores (10-40) and depressed mood. Results. Baseline hs-CRP was not associated with an increasing trend in SZSRDS scores and depressed mood in the total study population, but there was a significant gender interaction. Among the men, elevated hs-CRP was associated with an increasing trend in the SZSRDS score and depressed mood. Conclusions. High hs-CRP predicts a higher incident SZSRDS score and depressed mood among older men, suggesting a possible inflammatory etiology for depression.
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In 764 individuals, a positive correlation between hs-CRP levels and depression mood was shown exclusively in men.
“Another cross-sectional study, including 764 (336 male and 579 female) individuals assessed through the Short Zung Self Rating Depression Scale (SZRDS), showed a positive correlation between hs-CRP levels and depression mood, exclusively in men [67].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [67]
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- Authors
- Luukinen, H., Jokelainen, J., & Hedberg, P.
- Affiliations
- Oulu University Hospital (FI)
- Corresponding author
- Luukinen, Heikki
- ORCID
- Jokelainen, Jari
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 2010-01
- Volume
- 70
- Issue
- 2
- Pages
- 75-79
- ISSN
- 0036-5513 (ISSN-L)
- 1502-7686
- OpenAlex
- W2072932333
- Cited by
- 25
- References
- 18
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- high-sensitivity C-reactive protein, depressive mood, depression, older adults, inflammation, gender differences, incident depression, Zung Self-Rating Depression Scale, causal relationship
- MeSH terms
- Aged, Aged, 80 and over, C-Reactive Protein, Cognition Disorders, Depression, Female, Finland, Follow-Up Studies, Humans, Male, Psychiatric Status Rating Scales, Surveys and Questionnaires, Sex Characteristics, Logistic Models
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