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Surface area of the digestive tract – revisited

Helander, Herbert F, Fändriks, Lars·2014·Scandinavian Journal of Gastroenterology
DOI 10.3109/00365521.2014.898326
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Abstract

Background According to textbooks, the human gut mucosa measures 260-300 m(2), that is, in the order of a tennis court. However, the quantitative data are incomplete and sometimes conflicting. Objectives To review the literature regarding the mucosal surface area of the human digestive tract; to collect morphometric data from the parts of the gut where such data are missing; and to recalculate the mucosal surface area of the intestine in man. Methods With focus on the intestine, we carried out morphometry by light and electron microscopy on biopsies from healthy adult volunteers or patients with endoscopically normal mucosae. Results Literature review of intubation or radiological methods indicates an oroanal length of ∼5 m, two-third of which refers to the small intestine. However, there is a considerable variation between individuals. The inner diameter of the small intestine averages 2.5 cm and that of the large intestine averages 4.8 cm. The mucosa of the small intestine is enlarged ∼1.6 times by the plicae circulares. Morphometric data obtained by light and electron microscopy of biopsies demonstrate that villi and microvilli together amplify the small intestinal surface area by 60-120 times. Surface amplification due to microvilli in the colon is ∼6.5 times. The mean total mucosal surface of the digestive tract interior averages ∼32 m(2), of which about 2 m(2) refers to the large intestine. Conclusion The total area of the human adult gut mucosa is not in the order of t…

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Research works printed but not linked: 38

  1. Casteleyn C, 2010, Lab Anim, 44, 176, 10.1258/la.2009.009112 · DOI
  2. Snipes RL, 1997, Adv Anat Embryol Cell Biol, 138, 1, 10.1007/978-3-642-60822-3_1 · DOI
  3. Strkalj G, 2008, S Afr Med J, 98, 86
  4. Underhill BML, 1955, Br Med J, 4950, 1243, 10.1136/bmj.2.4950.1243 · DOI
  5. Snyder WS, 1975, Report of the task group on reference man
  6. van der Reis V, 1924, Ztschr f d ges exper Med, 43, 94, 10.1007/BF02618759 · DOI
  7. Niess JH, 2006, Cell microbiol, 8, 558, 10.1111/j.1462-5822.2006.00694.x · DOI
  8. 10.1126/science.1106442 · DOI
  9. 10.1002/bdd.2510160502 · DOI
  10. Ritschel WA, 1991, Methods Find Exp Clin Pharmacol, 13, 313
  11. Mayhew TM, 1991, Exp Physiol, 76, 639, 10.1113/expphysiol.1991.sp003533 · DOI
  12. Weibel ER, 1979, Stereological methods
  13. Naumova EA, 2013, Head Face Med, 9, 8, 10.1186/1746-160X-9-8 · DOI
  14. Long JD, 2006, Gastrointestinal and liver diseases, 841
  15. Scott GH, 1925, Am J Dis Child, 30, 147
  16. Cox AJ, 1945, Cal West Med, 63, 267
  17. Lillibridge CB, 1964, Gastroenterology, 47, 269, 10.1016/S0016-5085(19)34740-7 · DOI
  18. Bouras EP, 2002, Gut, 51, 781, 10.1136/gut.51.6.781 · DOI
  19. Blankenhorn DH, 1955, Proc Soc Exp Biol Med, 88, 356, 10.3181/00379727-88-21588 · DOI
  20. Backman L, 1974, Acta Chir Scand, 140, 57
  21. Fanucci A, 1988, Scand J Gastroenterol, 23, 574, 10.3109/00365528809093914 · DOI
  22. Hosseinpour M, 2008, Surg Radiol Anat, 30, 653, 10.1007/s00276-008-0398-2 · DOI
  23. Sadahiro S, 1992, Surg Radiol Anat, 14, 251, 10.1007/BF01794949 · DOI
  24. Saunders BP, 1995, Br J Surg, 82, 1491, 10.1002/bjs.1800821113 · DOI
  25. Khashab MA, 2009, Endoscopy, 41, 674, 10.1055/s-0029-1214899 · DOI
  26. Kerckring T, 1670, Spicilegium anatomicum
  27. Riecken EO, 1976, Dtsch med Wschr, 101, 51, 10.1055/s-0028-1105312 · DOI
  28. Dunne WT, 1977, Gut, 18, 290, 10.1136/gut.18.4.290 · DOI
  29. Helander KG, 1990, Hum Pathol, 21, 1235, 10.1016/S0046-8177(06)80036-5 · DOI
  30. Wu TC, 2002, Food Chem Toxicol, 4, 1901
  31. DeSesso M, 2001, Food Chem Toxicol, 3, 209, 10.1016/S0278-6915(00)00136-8 · DOI · Paper page
  32. Geibel JP, 2005, Annu Rev Physiol, 67, 471, 10.1146/annurev.physiol.67.031103.153530 · DOI
  33. 10.1152/physrev.00026.2001 · DOI · Paper page
  34. Pappenheimer JR, 1998, Comp Biochem Physiol A Mol Integr Physiol, 121, 45, 10.1016/S1095-6433(98)10100-9 · DOI
  35. Gross S, 1996, J Submicrosc Cytol Pathol, 28, 61
  36. Gardner LG, 1989, Q J Exp Physiol, 74, 257, 10.1113/expphysiol.1989.sp003269 · DOI
  37. Markiewicz A, 1992, Chronobiol Int, 9, 453, 10.3109/07420529209064559 · DOI
  38. Bhatnagar BNS, 2004, Clin Anat, 17, 236, 10.1002/ca.10204 · DOI

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Metadata

Authors
Helander, H. F., & Fändriks, L.
Venue
Scandinavian Journal of Gastroenterology
Publisher
Informa UK Limited
Published
2014-04-02
Volume
49
Issue
6
Pages
681-689
ISSN
  • 0036-5521
  • 1502-7708
DOI
10.3109/00365521.2014.898326
Cited by
860
References
0
Language
en

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