Glucagon-Like Peptide-1 7-36 Amide and Peptide YY from the L-Cell of the Ileal Mucosa Are Potent Inhibitors of Vagally Induced Gastric Acid Secretion in Man
Abstract
BACKGROUND: Glucagon-like peptide (GLP-1) 7-36 amide and peptide YY (PYY) from the L-cell of the ileal mucosa are potent inhibitors of gastric acid secretion in man. It is not clear, however, by which mechanism(s) they inhibit acid secretion. In dogs the inhibitory effect of PYY on acid secretion may be mediated mainly through neural pathways. The mechanism of action of GLP-1 might be similar. The aim of the present study was to examine the effects of GLP-1 might be similar. The aim of the present study was to examine the effects of GLP-1 and PYY on the vagally induced gastric acid secretion in man. METHODS: A modified sham feeding technique, chew and spit, was used. Six healthy volunteers were randomly assigned to receive intravenous infusion of saline, GLP-1 (41 pmol/kg/h), or peptide YY (50 pmol/kg/h). RESULTS: The infusion of GLP-1 and PYY resulted in plasma concentrations of 60 +/- 9 pmol/l and 84 +/- 11 pmol/l, respectively. GLP-1 and PYY both significantly inhibited the intergrated acid output by 67 +/- 6% and 68 +/- 9%, respectively, compared with the integrated outputs in a control experiment with saline infusion. Serum gastrin and plasma somatostatin concentrations remained unchanged during saline, GLP-1, and PYY infusions. CONCLUSIONS: GLP-1 and PYY are both potent inhibitors of the cephalic phase of acid secretion, indicating that at least part of the inhibitory effect of GLP-1 and PYY in man is mediated through neural pathways. Furthermore, the inhibitory effect seems to be independent of circulating concentrations of gastrin and somatostatin.
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There is evidence that GLP-1, administered peripherally or centrally, inhibits vagal activity in animals and humans.
“In addition to regulating glycemia, there is evidence that the neuropeptide GLP-1, administered peripherally or centrally, inhibits vagal activity in animals and humans (19, 50, 51) and increases sympathetic activity in rats (52, 53).”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [50]
Cites
Human distribution and release of a putative new gut hormone, peptide YY
Adrian, T. E., Ferri, G., Bacarese-Hamilton, A. J., Fuessl, H. S., Polak, J. M., & Bloom, S. R. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90211-2 · Cited by 1,064 · see citing works
Truncated GLP-1 (proglucagon 78?107-amide) inhibits gastric and pancreatic functions in man
Wettergren, A., Schjoldager, B., Mortensen, P. E., Myhre, J., Christiansen, J., & Holst, J. J. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01316798 · Cited by 670 · see citing works
Self-citationØrskov, C., Holst, J. J., & Nielsen, O. V. (1988) · Endocrinology · doi:10.1210/endo-123-4-2009 · Cited by 400 · see citing works
Self-citationØrskov, C., Jeppesen, J., Madsbad, S., & Holst, J. J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115012 · Cited by 378 · see citing works
Self-citationDetermination of gastrin in serum. An evaluation of the reliability of a radioimmunoassay.
STADIL, F., & Rehfeld, J. F. (1973) · PubMed · Cited by 301 · see citing works
Glucagon-like peptide-1, a new hormone of the entero-insular axis
Ørskov, C. (1992) · Diabetologia · doi:10.1007/bf00429088 · Cited by 294 · see citing works
Self-citationEffect of peptide YY on gastric, pancreatic, and biliary function in humans
Adrian, T. E., Savage, A. P., Sagor, G. R., Allen, J. M., Bacarese-Hamilton, A. J., Tatemoto, K., Polak, J. M., & Bloom, S. R. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90442-1 · Cited by 276 · see citing works
Complete Sequences of Glucagon-like Peptide-1 from Human and Pig Small Intestine
Ørskov, C., Bersani, M., Johnsen, A. H., Højrup, P., & Holst, J. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51561-1 · Cited by 210 · see citing works
Self-citationPancreatic and intestinal processing of proglucagon in man
Ørskov, C., Holst, J. J., Poulsen, S. S., & Kirkegaard, P. O. (1987) · Diabetologia · doi:10.1007/bf00274797 · Cited by 210 · see citing works
Self-citationCoexistence of peptide YY and glicentin immunoreactivity in endocrine cells of the gut
Böttcher, G., Sjölund, K., Ekblad, E., Håkanson, R., Schwartz, T. W., & Sundler, F. (1984) · Regulatory Peptides · doi:10.1016/0167-0115(84)90034-x · Cited by 185 · see citing works
Schjoldager, B., Mortensen, P. E., Christiansen, J., �rskov, C., & Holst, J. J. (1989) · Digestive Diseases and Sciences · doi:10.1007/bf01540341 · Cited by 178 · see citing works
Self-citationDemonstration of the Humoral Agent in Fat Inhibition of Gastric Secretion.
Kosaka, T., & Lim, R. K. S. (1930) · Experimental Biology and Medicine · doi:10.3181/00379727-27-5024 · Cited by 169 · see citing works
Time-varying magnetic fields increase cytosolic free Ca2+ in HL-60 cells
Carson, J. J. L., Prato, F. S., Drost, D. J., Diesbourg, L. D., & Dixon, S. J. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.259.4.c687 · Cited by 137 · see citing works
Ratio of Chymotrypsin to Trypsin in Human Duodenal Aspirate
Goldberg, D. M., Sale, J. K., & Wormsley, K. G. (2009) · Digestion · doi:10.1159/000197305 · Cited by 135 · see citing works
Characterization of saturable binding sites for circulating pancreatic polypeptide in rat brain
Whitcomb, D. C., Taylor, I. L., & Vigna, S. R. (1990) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1990.259.4.g687 · Cited by 133 · see citing works
Böttcher, G., Alumets, J., Håkanson, R., & Sundler, F. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90046-7 · Cited by 116 · see citing works
Kanse, S. M., Kreymann, B., Ghatei, M. A., & Bloom, S. R. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)81063-9 · Cited by 104 · see citing works
Enterogastrone-like effect of peptide YY is vagally mediated in the dog.
Pappas, T. N., Debas, H. T., & Taylor, I. L. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112300 · Cited by 95 · see citing works
On the accuracy of radioimmunological determination of somatostatin in plasma
Hilsted, L., & Holst, J. J. (1982) · Regulatory Peptides · doi:10.1016/0167-0115(82)90105-7 · Cited by 85 · see citing works
Self-citationNeuropeptide Y and peptide YY: major modulators of gastrointestinal blood flow and function
Sheikh, S. P. (1991) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1991.261.5.g701 · Cited by 70 · see citing works
Self-citationEffect of Glucagon-Like Peptide-1 on Gastric Somatostatin and Gastrin Secretion in the Rat
Eissele, R., Koop, H., & Arnold, R. (1990) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529009095514 · Cited by 55 · see citing works
Guo, Y.-S., Singh, P., Gomez, G. A., et al. (1987) · Gastroenterology · doi:10.1016/s0016-5085(87)91078-x · Cited by 42 · see citing works
Interaction between Secretin and Cholecystokinin on Inhibition of Gastric Secretion in Man
Henriksen, F. W., Sp, J., & Möller, S. (1974) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1974.12096904 · Cited by 30 · see citing works
Effect of glucagon on vagally induced gastric acid secretion in humans
Loud, F. B., Holst, J. J., Christiansen, J., & Rehfeld, J. F. (1988) · Digestive Diseases and Sciences · doi:10.1007/bf01536022 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371 · see citing works
Self-citationThe role of incretins in glucose homeostasis and diabetes treatment
Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824 · see citing works
Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms
I˙meryüz, N., Yeğen, B. Ç., Bozkurt, A., Coşkun, T., Villanueva-Peñacarrillo, M. L., & Ulusoy, N. B. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.4.g920 · Cited by 432 · see citing works
Graaf, C. D., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J.-M., Liao, J., Fletcher, M. M., Yang, D., et al. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011395 · Cited by 403 · see citing works
Flint, A., Raben, A., Ersbøll, A., Holst, J., & Astrup, A. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801627 · Cited by 384 · see citing works
Self-citationGlucagon-like peptide 1(GLP-1) in biology and pathology
Meier, J. J., & Nauck, M. A. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.538 · Cited by 288 · see citing works
Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans
Schirra, J., Sturm, K., Leicht, P., Arnold, R., Göke, B., & Katschinski, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1349 · Cited by 265 · see citing works
Glucagonlike peptide 1: a newly discovered gastrointestinal hormone
Holst, J. J. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90831-1 · Cited by 252 · see citing works
Self-citationDelgado-Aros, S., Kim, D.-Y., Burton, D. D., Thomforde, G. M., Stephens, D., Brinkmann, B. H., Vella, A., & Camilleri, M. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2002.282.3.g424 · Cited by 235 · see citing works
Wettergren, A., Wøjdemann, M., Meisner, S., Stadil, F., & Holst, J. J. (1997) · Gut · doi:10.1136/gut.40.5.597 · Cited by 153 · see citing works
Self-citationSchirra, J., Wank, U., Arnold, R., Göke, B., & Katschinski, M. (2002) · Gut · doi:10.1136/gut.50.3.341 · Cited by 130 · see citing works
Bharucha, A. E., Charkoudian, N., Andrews, C. N., Camilleri, M., Sletten, D., Zinsmeister, A. R., & Low, P. A. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00153.2008 · Cited by 98 · see citing works
Glucagon-like peptide 1 (GLP-1): a potent gut hormone with a possible therapeutic perspective
Nauck, M. A. (1998) · Acta Diabetologica · doi:10.1007/s005920050116 · Cited by 94 · see citing works
Nutrition and l and K-enteroendocrine cells
Gutierrez-Aguilar, R., & Woods, S. C. (2011) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e32834190b5 · Cited by 47 · see citing works
RANGANATH, L., NORRIS, F., MORGAN, L., WRIGHT, J., & MARKS, V. (1999) · Clinical Science · doi:10.1042/cs0960335 · Cited by 47 · see citing works
Andrews, C. N., Bharucha, A. E., Camilleri, M., Low, P. A., Seide, B. M., Burton, D. D., Nickander, K. K., Baxter, K. L., & Zinsmeister, A. R. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00923.x · Cited by 26 · see citing works
HOLST, J. J., TOFT-NIELSEN, M.-B., ØRSKOV, C., NAUCK, M., & WILLMS, B. (2006) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb17549.x · Cited by 21 · see citing works
Self-citationIsbil-Buyukcoskun, N., & Gulec, G. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2004.12.019 · Cited by 10 · see citing works
- Authors
- Wettergren, A., Petersen, H., ørskov, C., Christiansen, J., Sheikh, S. P., & Holst, J. J.
- Affiliations
- University of Copenhagen (DK)
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 1994-01
- Volume
- 29
- Issue
- 6
- Pages
- 501-505
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W2068493064
- Cited by
- 133
- References
- 24
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- glucagon-like peptide-1(7-36)amide, peptide YY, gastric acid secretion, vagus nerve stimulation, cephalic phase, neural pathways, gastrin, somatostatin, sham feeding, gut-brain axis
- MeSH terms
- Adult, Animals, Depression, Chemical, Glucagon-Like Peptides, Female, Gastric Acid, Gastrins, Glucagon, Humans, Ileum, Intestinal Mucosa, L Cells, Male, Middle Aged, Peptide Fragments, Peptides, Somatostatin, Vagus Nerve, Peptide YY, Mice, Glucagon-Like Peptide 1
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