Nutrition and l and K-enteroendocrine cells
Open accessAbstract
PURPOSE OF REVIEW: The review highlights the influence of nutrients over the secretion of several hormones produced by enteroendocrine cells in the gastrointestinal tract that secrete incretin hormones. These hormones influence glucose homeostasis; food intake; gastric, pancreatic and hepatic secretions; and gastric and intestinal motility, and these aspects are summarized in this review. RECENT FINDINGS: This study provides an overview of recent advances in our understanding of the physiology of the incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as of oxyntomodulin. A better understanding of the secretion and action of these hormones at their receptors was made possible by new techniques that allow investigation of individual enteroendocrine cells. SUMMARY: The better understanding of the function of the gastrointestinal incretin hormones and their implications for improving glucose homeostasis and perhaps influencing food intake and appetite as well, new research in this area will help combat metabolic diseases such as type 2 diabetes and obesity.
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GLP-1 improves glycaemic control and tissue sensitivity to insulin through numerous indirect systemic effects.
“In addition to acting on pancreatic cells, GLP-1 improves glycaemic control and tissues sensitivity to insulin through numerous indirect systemic effects.”
From GLP-1 receptor agonists and renal outcomes in patients with diabetes mellitus type 2 and diabetic kidney disease: state of the art (2022) · cites this paper as [9]
Activation of GLP-1 receptor in hypothalamic regulatory centres of hunger and satiety promotes weight loss and reduces food intake.
“The activation of GLP-1R in the hypothalamic regulatory centres of hunger and satiety promotes weight loss and reduces food intake.”
From GLP-1 receptor agonists and renal outcomes in patients with diabetes mellitus type 2 and diabetic kidney disease: state of the art (2022) · cites this paper as [9]
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Granata, A., Maccarrone, R., Anzaldi, M., Leonardi, G., Pesce, F., Amico, F., Gesualdo, L., & Corrao, S. (2022) · Clinical Kidney Journal · doi:10.1093/ckj/sfac069 · Cited by 54 · see citing works
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- Authors
- Gutierrez-Aguilar, R., & Woods, S. C.
- Affiliations
- University of Cincinnati (US)
- Corresponding author
- Woods, Stephen C
- ORCID
- Woods, Stephen C
- Venue
- Current Opinion in Endocrinology, Diabetes & Obesity
- Published
- 2011-02
- Volume
- 18
- Issue
- 1
- Pages
- 35-41
- ISSN
- 1752-296X (ISSN-L)
- PMC
- PMC3884637
- OpenAlex
- W2009365780
- Cited by
- 47
- References
- 80
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 2 · 2015: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Current Opinion in Endocrinology Diabetes and Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 017844, R01DK017844, R37DK017844)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- enteroendocrine cells, incretins, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, oxyntomodulin, glucose homeostasis, dietary intake, gastric secretion, pancreatic secretion, intestinal motility, type 2 diabetes, obesity
- MeSH terms
- Animals, Gastric Inhibitory Polypeptide, Humans, Models, Biological, Nutritional Physiological Phenomena, Drug Design, Enteroendocrine Cells, Glucagon-Like Peptide 1, Incretins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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