Cited by 130Gastrointestinal motility and disordersRegulation of Appetite and ObesityDiabetes Treatment and Management

Effects of glucagon-like peptide-1(7–36)amide on motility and sensation of the proximal stomach in humans

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Schirra, J, Wank, U, Arnold, R, Göke, B, Katschinski, M·2002·Gut

Abstract

Background: Glucagon-like peptide-1(7–36)amide (GLP-1) retards gastric emptying, reduces food intake, and inhibits antroduodenal and stimulates pyloric motility. Aims: To assess the effects of synthetic GLP-1 on fundus tone and volume waves, gastric compliance, and perception of gastric distension. Subjects: Eleven healthy male volunteers. Methods: Background infusions were saline, or GLP-1 at 0.3 or 0.9 pmol/ kg/min on separate days in random order. Interdigestive fundus motility was recorded by barostat (maximum capacity of intragastric bag 1200 ml) during basal and peptide periods of 60 minutes each. Thereafter stepwise isobaric distensions were performed with ongoing peptide infusion, and gastric sensation was scored. Results: Low and high loads of GLP-1 induced physiological and supraphysiological plasma immunoreactivities, respectively. GLP-1 dose dependently diminished fundus tone (162.9 (15.0) and 259.5 (17.2) v 121.1 (6.0) ml with saline; p<0.0001). It greatly reduced volume waves and total volume displaced by these events (p<0.0001). Gastric compliance derived from isobaric distension rose in a dose related manner (42.6 (5.5) and 63.6 (7.7) v 27.0 (3.5) ml/mm Hg; p=0.0004) with a concomitant reduction of the pressure at half maximum bag volume (6.4 (0.4) and 5.5 (0.4) v 7.2 (0.1) mm Hg; p<0.0001). GLP-1 did not change perception of isobaric distension but reduced the perception score related to corresponding bag volume (p<0.0001). Conclusions: GLP-1 is a candidate physiological inhibitory regulator of fundus motility. It allows the stomach to afford a larger volume without increase in sensation.

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  1. Straathof JWA, Neikens C, Lamers CBHW, et al. Effect of vagal cholinergic stimulation on the proximal stomach. Neurogastroenterol Motil 1998;10:437.

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Authors
Schirra, J., Wank, U., Arnold, R., Göke, B., & Katschinski, M.
Affiliations
  • Philipps University of Marburg (DE)
  • Ludwig-Maximilians-Universität München (DE)
Corresponding author
Katschinski, M
Venue
Gut
Publisher
BMJ
Published
2002-03
Volume
50
Issue
3
Pages
341-348
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
OpenAlex
W2129501738
Cited by
130
References
44
Citations by year
2026: 6 · 2025: 6 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 5 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 6
FWCI
5.54
Type
journal article
Language
en
Open access
Locations
  • Gut (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
glucagon-like peptide-1(7-36)amide, gastric compliance, gastric emptying, GLP-1 receptor agonists, barostat, antroduodenal motility
MeSH terms
Adult, Blood Glucose, Glucagon-Like Peptides, Gastric Emptying, Gastric Fundus, Gastrointestinal Hormones, Glucagon, Humans, Male, Muscle Relaxation, Peptide Fragments, Pressure, Satiety Response, Glucagon-Like Peptide 1

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