Effects of glucagon-like peptide-1(7–36)amide on motility and sensation of the proximal stomach in humans
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Background: Glucagon-like peptide-1(7–36)amide (GLP-1) retards gastric emptying, reduces food intake, and inhibits antroduodenal and stimulates pyloric motility. Aims: To assess the effects of synthetic GLP-1 on fundus tone and volume waves, gastric compliance, and perception of gastric distension. Subjects: Eleven healthy male volunteers. Methods: Background infusions were saline, or GLP-1 at 0.3 or 0.9 pmol/ kg/min on separate days in random order. Interdigestive fundus motility was recorded by barostat (maximum capacity of intragastric bag 1200 ml) during basal and peptide periods of 60 minutes each. Thereafter stepwise isobaric distensions were performed with ongoing peptide infusion, and gastric sensation was scored. Results: Low and high loads of GLP-1 induced physiological and supraphysiological plasma immunoreactivities, respectively. GLP-1 dose dependently diminished fundus tone (162.9 (15.0) and 259.5 (17.2) v 121.1 (6.0) ml with saline; p<0.0001). It greatly reduced volume waves and total volume displaced by these events (p<0.0001). Gastric compliance derived from isobaric distension rose in a dose related manner (42.6 (5.5) and 63.6 (7.7) v 27.0 (3.5) ml/mm Hg; p=0.0004) with a concomitant reduction of the pressure at half maximum bag volume (6.4 (0.4) and 5.5 (0.4) v 7.2 (0.1) mm Hg; p<0.0001). GLP-1 did not change perception of isobaric distension but reduced the perception score related to corresponding bag volume (p<0.0001). Conclusions: GLP-1 is a candidate physiological inhibitory regulator of fundus motility. It allows the stomach to afford a larger volume without increase in sensation.
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GLP-1 delays gastric emptying.
“In fact, quantitating the effect of GLP-1 on insulin secretion is not straightforward, given that GLP-1 delays gastric emptying (26) and is a glucose-dependent secretagogue.”
From A model of GLP-1 action on insulin secretion in nondiabetic subjects (2010) · cites this paper as [26]
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- Authors
- Schirra, J., Wank, U., Arnold, R., Göke, B., & Katschinski, M.
- Affiliations
- Philipps University of Marburg (DE)
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Katschinski, M
- ORCID
- Schirra, J
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2002-03
- Volume
- 50
- Issue
- 3
- Pages
- 341-348
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1773139
- OpenAlex
- W2129501738
- Cited by
- 130
- References
- 44
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 5 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 6
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- glucagon-like peptide-1(7-36)amide, gastric compliance, gastric emptying, GLP-1 receptor agonists, barostat, antroduodenal motility
- MeSH terms
- Adult, Blood Glucose, Glucagon-Like Peptides, Gastric Emptying, Gastric Fundus, Gastrointestinal Hormones, Glucagon, Humans, Male, Muscle Relaxation, Peptide Fragments, Pressure, Satiety Response, Glucagon-Like Peptide 1
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