The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Growth Factors and Wound Healing
Abstract
This paper is based on the thesis Growth Factors and Formation of Granulation Tissue, University of Göteborg, 1992. For the last decade, it has been acknowledged that growth factors are essential for regulating the cellular events involved in the formation of granulation tissue and in wound healing. Recently, clinical trials were initiated to study the wound healing effect of applying growth factors and growth hormone to human wounds. However, in order to apply growth factors in these trials in an intelligent and effective manner, it is important to understand their physiology and their role in wound healing. This review paper is about the growth factors: IGF-I, IGF-II, PDGF, bFGF, TGF-beta, EGF, TGF-alpha, TNF-alpha, SF-HGF and Growth Hormone and their role and effect in soft tissue wound healing in animals and humans.
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“Elevation of TNFα leads to decreased production of granulation tissue, whereas low doses of TNFα promote collagen disposition,58–61 demonstrating the importance of accurate cytokine regulation during wound healing.”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [60]
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Metadata
- Authors
- Steenfos, H. H.
- Affiliations
- Herlev Hospital (DK)
- Corresponding author
- Steenfos, Henrik H.
- Venue
- Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
- Publisher
- Informa UK Limited
- Published
- 1994-01
- Volume
- 28
- Issue
- 2
- Pages
- 95-105
- ISSN
- 0284-4311 (ISSN-L)
- OpenAlex
- W2040987751
- Cited by
- 192
- References
- 63
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- growth factors, wound healing, granulation tissue, insulin-like growth factor I, insulin-like growth factor II, platelet-derived growth factor, basic fibroblast growth factor, TGF-beta, epidermal growth factor, transforming growth factor-alpha, TNF-α, soft tissue wounds, growth hormone
- MeSH terms
- Animals, Epidermal Growth Factor, Growth Substances, Humans, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Lymphotoxin-alpha, Platelet-Derived Growth Factor, Growth Hormone, Tumor Necrosis Factor-alpha, Wound Healing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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