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The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway

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Stabilisation of cables of fibronectin with micromolar concentrations of copper: in vitro cell substrate properties

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Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals

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Wound dressings composed of copper-doped borate bioactive glass microfibers stimulate angiogenesis and heal full-thickness skin defects in a rodent model

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Bioactive Compounds for Skin Health: A Review

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The neglected role of copper ions in wound healing

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The Use of Copper as an Antimicrobial Agent in Health Care, Including Obstetrics and Gynecology

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Role of copper nanoparticles in wound healing for chronic wounds: literature review

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Bioinorganics and Wound Healing

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Using Copper to Improve the Well-Being of the Skin

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Tissue Concentrations of Zinc, Iron, Copper, and Magnesium During the Phases of Full Thickness Wound Healing in a Rodent Model

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Beneficial Regulation of Matrix Metalloproteinases for Skin Health

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An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

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Copper incorporated biomaterial-based technologies for multifunctional wound repair

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Effect of ion release from Cu-doped 45S5 Bioglass® on 3D endothelial cell morphogenesis

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Donut-like MOFs of copper/nicotinic acid and composite hydrogels with superior bioactivity for rh-bFGF delivering and skin wound healing

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Effectiveness of Copper Nanoparticles in Wound Healing Process Using In Vivo and In Vitro Studies: A Systematic Review

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Zinc-nutrient element based alloys for absorbable wound closure devices fabrication: Current status, challenges, and future prospects

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Cu-Releasing Bioactive Glass Coatings and Their in Vitro Properties

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Antibacterial and cell-friendly copper-substituted tricalcium phosphate ceramics for biomedical implant applications

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Topical N-Acetylcysteine Accelerates Wound Healing in Vitro and in Vivo via the PKC/Stat3 Pathway

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Multifunctional metal–organic frameworks for wound healing and skin regeneration

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Copper oxide nanoparticles infused electrospun polycaprolactone/gelatin scaffold as an antibacterial wound dressing

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Microneedle-Mediated Delivery of Copper Peptide Through Skin

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Beneficial Regulation of Fibrillar Collagens, Heat Shock Protein-47, Elastin Fiber Components, Transforming Growth Factor-β1, Vascular Endothelial Growth Factor and Oxidative Stress Effects by Copper in Dermal Fibroblasts

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Emerging nanomaterials for novel wound dressings: From metallic nanoparticles and MXene nanosheets to metal-organic frameworks

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Increased pro‐collagen 1, elastin, and TGF‐β1 expression by copper ions in an ex‐vivo human skin model

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rPDAs doped antibacterial MOF-hydrogel: bio-inspired synergistic whole-process wound healing

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Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes

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How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies

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Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells

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Co-Treatment of Copper Oxide Nanoparticle and Carbofuran Enhances Cardiotoxicity in Zebrafish Embryos

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Reduction of facial wrinkles depth by sleeping on copper oxide‐containing pillowcases: a double blind, placebo controlled, parallel, randomized clinical study

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Zinc, Copper, and Iron in Selected Skin Diseases

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Amino Acid Composition of Protein-Enriched Dried Pasta: Is It Suitable for a Low-Carb Diet?

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Enhancing Wound Healing With Sprayable Hydrogel Releasing Multi Metallic Ions: Inspired by the Body's Endogenous Healing Mechanism

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Expression and Purification of Recombinant GHK Tripeptides Are Able to Protect against Acute Cardiotoxicity from Exposure to Waterborne-Copper in Zebrafish

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The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice

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Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings

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Preparation, characterization, bioactivity and degradation behavior in vitro of copper-doped calcium polyphosphate as a candidate material for bone tissue engineering

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Green synthesis of copper oxide nanoparticles using Artemisia annua aqueous extract and its characterization, antioxidant, and burn wound healing activities

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Increase in skin surface elasticity in normal volunteer subjects following the use of copper oxide impregnated socks

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Copper Ions Ameliorated Thermal Burn-Induced Damage in ex vivo Human Skin Organ Culture

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Chitosan-based composite scaffolds for accelerated epidermal-dermal wound healing

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Mechanisms and design strategies of copper-incorporated dressings for wound management

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DNA Double-Strand Breaks Induced in Human Cells by Twelve Metallic Species: Quantitative Inter-Comparisons and Influence of the ATM Protein

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The ectoenzyme-side of matrix metalloproteinases (MMPs) makes inflammation by serum amyloid A (SAA) and chemokines go round

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Synergistic effect of copper and amino acid mixtures on the production of extracellular matrix proteins in skin fibroblasts

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Skin biological responses to urban pollution in an ex vivo model

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Safety of Using Diapers Containing Copper Oxide in Chronic Care Elderly Patients

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Gold Nanoparticles Functionalized with Angiogenin for Wound Care Application

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Investigation of functional characteristics of copper/copper oxide nanoparticles synthesized with Moringa oleifera and Musa sps. extracts: in-vitro and porcine study

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Engineering a bacterial polysaccharide-based metal–organic framework-enhanced bioactive 3D hydrogel for accelerated full-thickness wound healing

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Chemical Composition and Protective Effect of Young Barley (Hordeum vulgare L.) Dietary Supplements Extracts on UV-Treated Human Skin Fibroblasts in In Vitro Studies

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Skin Cancer, Polyphenols, and Oxidative Stress

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Copper-Macrophage Crosstalk: Potential Molecular Mechanisms and Therapeutic Applications in Infected Wound Healing.

Yang, J., Qin, J., Xu, B.-L., Liu, H.-Y., & Wang, X. (2025) · Small · doi:10.1002/smll.202509183 · Cited by 13 · see citing works

Three-dimensional endothelial cell morphogenesis under controlled ion release from copper-doped phosphate glass

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Continuum of care in hard-to-heal wounds by copper dressings: A case series

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Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical Trial

Melamed, E. A., Dabbah, J., Israel, T., Kan, I., Pinzur, M. S., Roth, T., & Borkow, G. (2025) · Advances in Wound Care · doi:10.1089/wound.2024.0273 · Cited by 10 · see citing works

Effects of copper‐impregnated collagen implants on local pro‐ and anti‐inflammatory and regenerative tissue reactions following implantation in rats

Hoene, A., Lucke, S., Walschus, U., Hackbarth, C., Prinz, C., Evert, F., Neumann, H. G., & Schlosser, M. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36865 · Cited by 10 · see citing works

Analysis of the Effect of Wearing Copper Oxide Impregnated Socks on tinea pedis Based on “Before and After” Pictures – A Statistical Follow-up Tool

Gargiulo, M. E., Elías, A. D. C., & Borkow, G. (2012) · The Open Biology Journal · doi:10.2174/1874196701205010017 · Cited by 10 · see citing works

Nanocomposite hydrogel with multiple metal ions coupling for effective treatment of bacteria infected wound via cascade catalysis and tissue regeneration

Liu, Y., Mu, W., Wang, Y., Liu, T., Peng, Z., & Chen, X. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.161783 · Cited by 9 · see citing works

Beneficial Regulation of Cellular Oxidative Stress Effects, and Expression of Inflammatory, Angiogenic, and the Extracellular Matrix Remodeling Proteins by 1α,25-Dihydroxyvitamin D3 in a Melanoma Cell Line

Philips, N. E., Samuel, P., Keller, T., Alharbi, A., Alshalan, S., & Shamlan, S.-A. (2020) · Molecules · doi:10.3390/molecules25051164 · Cited by 9 · see citing works

Dual-function membranes based on alginate/methyl cellulose composite for control drug release and proliferation enhancement of fibroblast cells

Abbas, H. A., Mabrouk, M., Soliman, A. A. F., & Beherei, H. H. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.08.171 · Cited by 9 · see citing works

Regenerative Activities of ROS-Modulating Trace Metals in Subcutaneously Implanted Biodegradable Cryogel

Yergeshov, A. A., Zoughaib, M., Ishkaeva, R. A., Savina, I. N., & Abdullin, T. I. (2022) · Gels · doi:10.3390/gels8020118 · Cited by 9 · see citing works

Facial Skin Lifting and Brightening Following Sleep on Copper Oxide Containing Pillowcases

Borkow, G., & Elías, A. D. C. (2016) · Cosmetics · doi:10.3390/cosmetics3030024 · Cited by 9 · see citing works

Rpdas Doped Antibacterial Mof-Hydrogel: Bio-Inspired Synergistic Whole-Process Wound HealingPreprint

Wang, Y., Qi, W., Mao, Z., Wang, J., Zhao, R. C., & Chen, H. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4350215 · Cited by 9 · see citing works

The Multifaceted Properties of Copper and Zinc in Skin Healing

Kluger, N., Lain, E., Frasson, N. C., Doat, G., Stennevin, A., & Bianchi, P. (2025) · Dermatology and Therapy · doi:10.1007/s13555-025-01575-z · Cited by 8 · see citing works

Healing Effect of a Nano-Functionalized Medical-Grade Honey for the Treatment of Infected Wounds

Salvo, J., Sandoval, C., Schencke, C., Acevedo, F., & del Sol, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092187 · Cited by 8 · see citing works

The Beneficial Regulation of Extracellular Matrix and Heat Shock Proteins, and the Inhibition of Cellular Oxidative Stress Effects and Inflammatory Cytokines by 1α, 25 dihydroxyvitaminD3 in Non-Irradiated and Ultraviolet Radiated Dermal Fibroblasts

Philips, N. E., Ding, X., Kandalai, P., Marte, I., Krawczyk, H., & Richardson, R. (2019) · Cosmetics · doi:10.3390/cosmetics6030046 · Cited by 7 · see citing works

Skin Aging and Oxidative Stress

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Pressure Ulcers and Nutrients: From Established Evidence to Gaps in Knowledge

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Copper-based dressing: Efficacy in a wound infection of ex vivo human skin

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Salivary Electrolytes in Patients with Periodontal Disease

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Biological properties of copper: Antibacterial, osteogenesis of biomaterials

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Anti-aging and anti-carcinogenic effects of 1α, 25-dihyroxyvitamin D3 on skin

Philips, N. E., Portillo-Esnaola, M., Samuel, P., Gallego-Rentero, M., Keller, T., & Franco, J. (2022) · Plastic and Aesthetic Research · doi:10.20517/2347-9264.2021.83 · Cited by 3 · see citing works

“Skin cancer, polyphenols, and oxidative stress” or Counteraction of oxidative stress, inflammation, signal transduction pathways, and extracellular matrix remodeling that mediate skin carcinogenesis by polyphenols

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Effect of zinc or copper supplementation on the efficacy and sustainability of botulinum toxin A “Botox” injection in masseter muscle of albino rats

Elgendy, Y. S., Elzoghby, S., & AbuBakr, N. (2024) · Journal of Stomatology Oral and Maxillofacial Surgery · doi:10.1016/j.jormas.2024.102156 · Cited by 2 · see citing works

Targeting cu metabolism as a potential therapeutic strategy for pulmonary fibrosis

Li, B., Zhang, M., Cai, J., Li, N. S., Li, X.-H., & Cheng, H. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189379 · Cited by 2 · see citing works

Diagnostics of skin features through 3D skin mapping based on electro-controlled deposition of conducting polymers onto metal-sebum modified surfaces and their possible applications in skin treatment

Fu, X., Cheong, Y. H., Ahamed, A., Zhou, C. Z., Robert, C., Krikstolaityte, V., Gordon, K. C., & Lisak, G. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.10.056 · Cited by 2 · see citing works

Copper Dressings as part of the armamentarium in the fight against wounds – much more than an antimicrobial

Borkow, G., Cheyne, I., & Melamed, E. (2024) · Wound Healing Southern Africa · doi:10.36303/whsa.839 · Cited by 1 · see citing works

Ameliorative effects of Copper(II) albumin complex against zinc oxide nanoparticles induced oxidative DNA damage in Sprague Dawley rats

Abdelnaem, A. M., Fathy, H. M., Yahia, D., Ali, M. F. B., Nassar, A. Y., & Almaz, D. (2024) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-024-00208-w · Cited by 1 · see citing works

Photocarcinogenesis and Molecular Mechanism

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Green synthesis of copper nanoparticles using Artemisia annua aqueous extract and its characterization, antioxidant and burn wound healing activitiesPreprint

Karimí, B., Mardani, M., Kaboutari, J., Javdani, M., Albadi, J., & Shirian, S. (2023) · Research Square · doi:10.21203/rs.3.rs-2576393/v1 · Cited by 1 · see citing works

New insight into erythema reduction induced by quercetin metal ions chelatesPreprint

Alvarez, A. B., Arvesen, K. B., Hjuler, K. F., Bjerring, P., & Petersen, S. B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.04.626931 · Cited by 1 · see citing works

Skin Diseases-Related Enzymes: Mechanisms and Clinical Applications

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Conducting polymer based materials for on-skin applications

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ẢNH HƯỞNG CỦA THỜI GIAN CHIẾU TIA UVA NHÂN TẠO LÊN MỨC ĐỘ TỔN THƯƠNG DA CHUỘT NHẮT TRẮNG (Mus musculus var. albino)

Huyền, N. T. T., Hân, N. N., Thúy, T. T., & Tú, T. C. (2023) · Tạp chí Khoa học · doi:10.54607/hcmue.js.20.6.3841(2023

New Insight into Erythema Reduction Induced by Quercetin-Metal Ion ChelatesPreprint

Alvarez, A. B., Arvesen, K. B., Hjuler, K. F., Bjerring, P., & Petersen, S. B. (2025) · Qeios · doi:10.32388/6be58r

Additional file 1 of Donut-like MOFs of copper/nicotinic acid and composite hydrogels with superior bioactivity for rh-bFGF delivering and skin wound healing

Wang, T.-L., Zhou, Z.-F., Liu, J.-F., Hou, X.-D., Zhou, Z., Dai, Y.-L., Hou, Z.-Y., Chen, F., & 郑龙坡 (2021) · Figshare · doi:10.6084/m9.figshare.16599491

Metallic Nanoparticles for Wound Healing Management: A Promising Therapeutic Approach

Adhikari, M. D., & Tiwary, B. K. (2025) · Smart nanomaterials technology · doi:10.1007/978-981-95-0720-7_5

A defined copper ion window coordinates multicellular responses for predictive vascular implant design

Zou, D., Yang, P., Jiang, L., & Li, L. (2026) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2026.130979

Wound Debridement with Copper Oxide Dressings: Bridging the Gap Between Clinical Observations and the Basic Science Underlying Endogenous Autolysis

Melamed, E. A., & Cheyne, I. (2026) · Journal of Functional Biomaterials · doi:10.3390/jfb17070350

Controlled delivery of Cu 2+ and Zn 2+ ions from chitosan scaffolds: media-dependent release of ions and its influence on cellular responses relevant to wound healing

Linju, M. C., & Rekha, M. R. (2026) · Journal of Materials Chemistry B · doi:10.1039/d6tb00788k

A pro-regenerative petroleum jelly-based, copper-doped bioactive glass ointment for impaired wound healing in metabolic syndrome

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Beneficial Regulation of Fibrillar Collagens, Heat Shock Protein-47, Elastin Fiber Components, Transforming Growth Factor-β1, Vascular Endothelial Growth Factor and Oxidative Stress Effects by Copper in Dermal Fibroblasts

Philips, N., Samuel, P., Parakandi, H., Gopal, S., Siomyk, H., Ministro, A., Thompson, T., & Borkow, G. (2012) · Connective Tissue Research · doi:10.3109/03008207.2012.665970 · Cited by 44 · see citing works

Clinical Uses of Copper in Skin Aging and Wound Healing

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The tripeptide-copper complex glycyl-L-histidyl-L- lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures

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613 Evaluating the role of copper ions in the various phases of burn and wound healing by using an ex vivo human burn model

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Combined Metallomics/Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair

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