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Cited by 8Bee Products Chemical AnalysisWound Healing and TreatmentsNanoparticles: synthesis and applications

Healing Effect of a Nano-Functionalized Medical-Grade Honey for the Treatment of Infected Wounds

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Salvo, Jessica, Sandoval, Cristian, Schencke, Carolina, Acevedo, Francisca, del Sol, Mariano·2023·Pharmaceutics
DOI 10.3390/pharmaceutics15092187PMC PMC10536296
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Abstract

Based on the qualities of Ulmo honey (Eucryphia cordifolia), a medical-grade honey (Ulmoplus®) has been developed. Relevant to this, the use of copper represents an emerging therapy for the treatment of wounds. Therefore, the aim of this study was to see how this medical-grade honey with copper nanoparticles (CuNPs) helped to heal infected or non-infected wounds. Twenty-four guinea pigs (Cavia porcellus) were divided into four groups for phase 1 (without and with infection, U + F1 and U + F2), and two groups for phase 2 (selected formulation, without and with infection, U + F2NI and U + F2I). Bacteriological and histopathological studies, collagen fibers content evaluation, and stereological analysis were performed. The selected formulation displayed the same antibacterial potency as Ulmoplus®, indicating that this medical-grade honey by itself can be used as an antibacterial agent. However, the evaluation of collagen content demonstrated a significant increase in fibroblast and type III collagen fibers for infected and uninfected groups, which correlated with the histopathological study. Therefore, it is correct to affirm that adding CuNPs to Ulmoplus® improved the maturation of collagen fibers. Finally, polymorphonuclear cells presented similar values between experimental groups, which would indicate that the formulation under study was able to regulate the inflammatory process despite their infectious condition.

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Authors
Salvo, J., Sandoval, C., Schencke, C., Acevedo, F., & del Sol, M.
Affiliations
  • Universidad de La Frontera (CL)
  • Universidad Autónoma de Chile (CL)
  • Programa de Doctorado en Ciencias Morfológicas, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile
Corresponding author
Schencke, Carolina
ORCID
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2023-08-24
Volume
15
Issue
9
Pages
2187
ISSN
1999-4923 (ISSN-L)
DOI
10.3390/pharmaceutics15092187
PMC
PMC10536296
OpenAlex
W4386137382
Cited by
8
References
5
Citations by year
2026: 1 · 2025: 3 · 2024: 4
FWCI
1.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmaceutics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Omeka S (Universidad de La Frontera) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Universidad de La Frontera (DI22-0063, 2019-21190160)
  • ANID-PFCHA/Doctorado Nacional (DI22-0063, 2019-21190160)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Bee Products Chemical Analysis
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Keywords
medical-grade honey, Eucryphia cordifolia, copper nanoparticles, wound infection, wound healing, antibacterial activity, collagen fibers, type III collagen, fibroblast proliferation, inflammation, polymorphonuclear leukocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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