The immune system in irritable bowel syndrome

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works

Functional Bowel Disorders

Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856 · see citing works

Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.

Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works

Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome

Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475 · see citing works

Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles

O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works

Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute <i>Campylobacter</i> enteritis and in post-dysenteric irritable bowel syndrome

Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155 · see citing works

Protease-Activated Receptors: Contribution to Physiology and Disease

Ossovskaya, V., & Bunnett, N. W. (2004) · Physiological Reviews · doi:10.1152/physrev.00028.2003 · Cited by 1,079 · see citing works

Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation

Pimentel, M., Lembo, A., Chey, W. D., Zakko, S., Ringel, Y., Yu, J., Mareya, S. M., Shaw, A. L., Bortey, E., & Forbes, W. P. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1004409 · Cited by 1,036 · see citing works

Postinfectious Irritable Bowel Syndrome

Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024 · see citing works

The Fecal Microbiota of Irritable Bowel Syndrome Patients Differs Significantly From That of Healthy Subjects

Kassinen, A., Krogius-Kurikka, L., Mäkivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J., & Palva, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.005 · Cited by 1,002 · see citing works

Activation of the mucosal immune system in irritable bowel syndrome

Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833 · see citing works

Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome

Barbara, G., Wang, B., Stanghellini, V., de Giorgio, R., Cremon, C., Di Nardo, G., Trevisani, M., Campi, B., Geppetti, P., Tonini, M., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.039 · Cited by 783 · see citing works

The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review

Moayyedi, P., Ford, A. C., Talley, N. J., Cremonini, F., Foxx-Orenstein, A. E., Brandt, L. J., & Quigley, E. M. M. (2010) · Gut · doi:10.1136/gut.2008.167270 · Cited by 728 · see citing works

Analysis of the Fecal Microbiota of Irritable Bowel Syndrome Patients and Healthy Controls with Real-Time PCR

Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699 · see citing works

Immune Activation in Patients With Irritable Bowel Syndrome

Liebregts, T., Adam, B., Bredack, C., Röth, A., Heinzel, S., Lester, S., Downie–Doyle, S., Smith, E., Drew, P., Talley, N. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.046 · Cited by 660 · see citing works

Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?

Dinan, T. G., Quigley, E. M. M., Ahmed, S. M. M., Scully, P., O’Brien, S., O’Mahony, L., O’Mahony, S., Shanahan, F., & Keeling, P. W. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.033 · Cited by 636 · see citing works

Role for protease activity in visceral pain in irritable bowel syndrome

Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591 · cited 5× · see citing works

Effects of gender and sex steroids on the immune response

Schuurs, A. H. W. M., & Verheul, H. A. M. (1990) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(90)90270-3 · Cited by 587 · see citing works

Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS

Dunlop, S. P., Jenkins, D., Neal, K. R., & Spiller, R. C. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.028 · Cited by 583 · see citing works

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

Piche, T., Barbara, G., Aubert, P., Bruley des Varannes, S., Dainese, R., Nano, J. L., Cremon, C., Stanghellini, V, De Giorgio, R., Galmiche, J. P., et al. (2009) · Gut · doi:10.1136/gut.2007.140806 · Cited by 540 · see citing works

Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

Akbar, A., Yiangou, Y., Facer, P., Walters, J. R. F., Anand, P., & Ghosh, S. (2008) · Gut · doi:10.1136/gut.2007.138982 · Cited by 526 · see citing works

Targeting the Human Microbiome With Antibiotics, Probiotics, and Prebiotics: Gastroenterology Enters the Metagenomics Era

Preidis, G. A., & Versalovic, J. A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.072 · Cited by 485 · see citing works

Increased mast cells in the irritable bowel syndrome

O’Sullivan, Clayton, Breslin, Harman, Bountra, Mclaren, & O’Morain (2000) · Neurogastroenterology &amp; Motility · doi:10.1046/j.1365-2982.2000.00221.x · Cited by 480 · see citing works

Abnormal Intestinal Permeability in Subgroups of Diarrhea-Predominant Irritable Bowel Syndromes

Dunlop, S. P., Hebden, J., Campbell, E., Naesdal, J., Olbe, L., Perkins, A. C., & Spiller, R. C. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00672.x · Cited by 476 · see citing works

Systematic review and meta-analysis: the incidence and prognosis of post-infectious irritable bowel syndrome

THABANE, M., KOTTACHCHI, D. T., & MARSHALL, J. K. (2007) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2007.03399.x · Cited by 466 · see citing works

Mast cells are closely apposed to nerves in the human gastrointestinal mucosa

Stead, R. H., Dixon, M. F., Bramwell, N. H., Riddell, R. H., & Bienenstock, J. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90627-6 · Cited by 445 · see citing works

Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome

Fukudo, S., Nomura, T., & Hongo, M. (1998) · Gut · doi:10.1136/gut.42.6.845 · Cited by 387 · see citing works

Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis

Wang, L.-H., Fang, X.-C., & Pan, G.-Z. (2004) · Gut · doi:10.1136/gut.2003.021154 · Cited by 387 · cited 1× · see citing works

Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum

Guilarte, M., Santos, J., de Torres, I., Alonso, C., Vicario, M., Ramos, L., Martinez, C., Casellas, F., Saperas, E., & Malagelada, J. R. (2007) · Gut · doi:10.1136/gut.2006.100594 · Cited by 385 · see citing works

Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome

Zhou, Q., Zhang, B., & Verne, N. G. (2009) · Pain · doi:10.1016/j.pain.2009.06.017 · Cited by 373 · see citing works

Corticotropin-releasing factor receptors and stress-related alterations of gut motor function

Taché, Y., & Bonaz, B. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30085 · Cited by 373 · see citing works

Incidence and Epidemiology of Irritable Bowel Syndrome After a Large Waterborne Outbreak of Bacterial Dysentery

Marshall, J. K., Thabane, M. E., Garg, A. X., Clark, W. F., Salvadori, M. I., & Collins, S. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.053 · Cited by 370 · see citing works

Distinctive Clinical, Psychological, and Histological Features of Postinfective Irritable Bowel Syndrome

Dunlop, S. P., Jenkins, D., & Spiller, R. C. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07542.x · Cited by 359 · see citing works

Psychoneuroimmunology and Psychosomatic Medicine: Back to the Future

Kiecolt‐Glaser, J. K., McGuire, L. M., Robles, T. F., & Glaser, R. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200201000-00004 · Cited by 359 · see citing works

Activation of Human Enteric Neurons by Supernatants of Colonic Biopsy Specimens From Patients With Irritable Bowel Syndrome

Buhner, S., Li, Q., Vignali, S., Barbara, G., De Giorgio, R., Stanghellini, V., Cremon, C., Zeller, F., Langer, R., Daniel, H., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.005 · Cited by 351 · see citing works

Mucosal Immune Activation in Irritable Bowel Syndrome: Gender-Dependence and Association With Digestive Symptoms

Cremon, C., Gargano, L., Morselli-Labate, A. M., Santini, D., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Corinaldesi, R., & Barbara, G. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.94 · Cited by 342 · see citing works

Terminal ileal mucosal mast cells in irritable bowel syndrome

Weston, A. P., Biddle, W. L., Bhatia, P. S., & Miner, P. B. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303164 · Cited by 338 · see citing works

The Mast Cell in Interstitial Cystitis: Role in Pathophysiology and Pathogenesis

Sant, G. R., Kempuraj, D., Marchand, J. E., & Theoharides, T. C. (2007) · Urology · doi:10.1016/j.urology.2006.08.1109 · Cited by 336 · see citing works

Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity

Gecse, K., Róka, R., Ferrier, L., Leveque, M., Eutamene, H., Cartier, C., Ait-Belgnaoui, A., Rosztóczy, A., Izbéki, F., Fioramonti, J., et al. (2008) · Gut · doi:10.1136/gut.2007.140210 · Cited by 314 · see citing works

Functional gastrointestinal disorders and mood disorders in patients with inactive inflammatory bowel disease: Prevalence and impact on health

Farrokhyar, F., Marshall, J. K., Easterbrook, B., & Irvine, J. E. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000195391.49762.89 · Cited by 310 · see citing works

Biopsychosocial Model of Irritable Bowel Syndrome

Tanaka, Y., Kanazawa, M., Fukudo, S., & Drossman, D. A. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.2.131 · Cited by 305 · see citing works

Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario

Marshall, J. K., Thabane, M., Garg, A. X., Clark, W., Meddings, J., Collins, S. M., & for the WEL Investigators (2004) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2004.02284.x · Cited by 292 · see citing works

Symptoms of irritable bowel syndrome in ulcerative colitis in remission

Isgar, B., Harman, M., Kaye, M. D., & Whorwell, P. J. (1983) · Gut · doi:10.1136/gut.24.3.190 · Cited by 274 · see citing works

Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component?: Table 1

Gonsalkorale, W. M., Perrey, C., Pravica, V, Whorwell, P. J., & Hutchinson, I. V. (2003) · Gut · doi:10.1136/gut.52.1.91 · Cited by 273 · see citing works

Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia

WALKER, M. M., TALLEY, N. J., PRABHAKAR, M., PENNANEAC’H, C. J., ARO, P., RONKAINEN, J., STORSKRUBB, T., HARMSEN, W. S., ZINSMEISTER, A. R., & AGREUS, L. (2009) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2009.03937.x · Cited by 261 · see citing works

Genetic Risk Factors for Post-Infectious Irritable Bowel Syndrome Following a Waterborne Outbreak of Gastroenteritis

Villani, A., Lemire, M., Thabane, M., Belisle, A., Geneau, G., Garg, A. X., Clark, W. F., Moayyedi, P., Collins, S. M., Franchimont, D., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.049 · Cited by 244 · see citing works

Contribution of the microflora to proteolysis in the human large intestine

Macfarlane, G. T., Allison, C., Gibson, S. A. W., & Cummings, J. H. (1988) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1988.tb02427.x · Cited by 237 · see citing works

New pathophysiological mechanisms in irritable bowel syndrome

Barbara, G., GIORGIO, R. D., Stanghellini, V., Cremon, C., Salvioli, B., & Corinaldesi, R. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02036.x · Cited by 221 · see citing works

Role of Tumor Necrosis Factor-alpha and Interleukin-10 Gene Polymorphisms in Irritable Bowel Syndrome

van der Veek, P. P. J., van den Berg, M., de Kroon, Y. E., Verspaget, H. W., & Masclee, A. A. M. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00257.x · Cited by 217 · see citing works

Hyperinnervation and Mast Cell Activation May Be Used as Histopathologic Diagnostic Criteria for Vulvar Vestibulitis

Bornstein, J., Goldschmid, N., & Sabo, E. (2004) · Gynecologic and Obstetric Investigation · doi:10.1159/000079663 · Cited by 201 · see citing works

Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome

Piche, T., Saint-Paul, M. C., Dainese, R., Marine-Barjoan, E., Iannelli, A., Montoya, M. L., Peyron, J. F., Czerucka, D., Cherikh, F., Filippi, J., et al. (2008) · Gut · doi:10.1136/gut.2007.127068 · Cited by 198 · see citing works

Review article: probiotics and prebiotics in irritable bowel syndrome

SPILLER, R. (2008) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2008.03750.x · Cited by 190 · see citing works

Quality of life in inflammatory bowel disease in remission: The impact of IBS-like symptoms and associated psychological factors

Simrén, M. (2002) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(01)04037-0 · Cited by 186 · see citing works

Irritable bowel syndrome: towards biomarker identification

Clarke, G. A., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.08.001 · Cited by 180 · see citing works

Randomized, double‐blind, placebo‐controlled trial of prednisolone in post‐infectious irritable bowel syndrome

Dunlop, S., Jenkins, D., Neal, K. R., Næsdal, J., Borgaonker, M., Collins, S. M., & Spiller, R. E. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01640.x · Cited by 178 · see citing works

Functional gastrointestinal disorders and mast cells: implications for therapy

Barbara, G., Stanghellini, V., GIORGIO, R. D., & Corinaldesi, R. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00685.x · Cited by 176 · see citing works

The Yield of Colonoscopy in Patients With Non-Constipated Irritable Bowel Syndrome: Results From a Prospective, Controlled US Trial

Chey, W. D., Nojkov, B., Rubenstein, J. H., Dobhan, R. R., Greenson, J. K., & Cash, B. D. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.55 · Cited by 175 · see citing works

Mucosal cytokine imbalance in irritable bowel syndrome

Macsharry, J., O'Mahony, L., Fanning, A., Bairead, E., Sherlock, G., Tiesman, J., Fulmer, A., Kiely, B., Dinan, T. G., Shanahan, F., et al. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802276127 · Cited by 174 · see citing works

Symptomatic overlap between irritable bowel syndrome and microscopic colitis

Limsui, D., Pardi, D. S., Camilleri, M., Loftus, E. V., Kammer, P. P., Tremaine, W. J., & Sandborn, W. J. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20059 · Cited by 167 · see citing works

Immune dysfunction in patients with functional gastrointestinal disorders

Kindt, S., Van Oudenhove, L., Broekaert, D., Kasran, A., Ceuppens, J. L., Bossuyt, X., Fischler, B., & Tack, J. (2009) · Neurogastroenterology &amp; Motility · doi:10.1111/j.1365-2982.2008.01220.x · Cited by 165 · see citing works

T-Cell Activation in Patients With Irritable Bowel Syndrome

Öhman, L., Isaksson, S., Lindmark, A.-C., Posserud, I., Stotzer, P.-O., Strid, H., Sjövall, H., & Simrén, M. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.116 · Cited by 165 · see citing works

Diarrhoea-predominant irritable bowel syndromedistinguishable by 16S rRNA gene phylotype quantifcation

Lyra, A., Rinttilä, T., Nikkilä, J., Krogius-Kurikka, L., Kajander, K., Malinen, E., Mättö, J., Mäkelä, L., & Palva, A. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5936 · Cited by 160 · see citing works

Celiac disease and irritable bowel-type symptoms

O’Leary, C., Wieneke, P., Buckley, S., O’Regan, P., Cronin, C. C., Quigley, E. M. M., & Shanahan, F. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05690.x · Cited by 154 · see citing works

Measurement of serum 7α‐hydroxy‐4‐cholesten‐3‐one (or 7αC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography‐tandem mass spectrometry

Camilleri, M., Nadeau, A., Tremaine, W. J., Lamsam, J., Burton, D., Odunsi, S., Sweetser, S., & Singh, R. (2009) · Neurogastroenterology &amp; Motility · doi:10.1111/j.1365-2982.2009.01288.x · Cited by 153 · see citing works

Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review

Park, M., & Camilleri, M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00745.x · Cited by 148 · see citing works

Oral Cromolyn Sodium in Comparison with Elimination Diet in the Irritable Bowel Syndrome, Diarrheic Type Multicenter Study of 428 Patients

Stefanini, G. F., Saggioro, A., Alvisi, V., Angelini, G., Capurso, L., Lorenzo, G. D., Dobrilla, G., Dodero, M. C. R., Galimberti, M., Gasbarrini, A., et al. (1995) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529509089786 · Cited by 147 · see citing works

Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation

Fukudo, S. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-006-1942-7 · Cited by 147 · see citing works

Enhanced Cholinergic-Mediated Increase in the Pro-Inflammatory Cytokine IL-6 in Irritable Bowel Syndrome: Role of Muscarinic Receptors

Dinan, T. G., Clarke, G., Quigley, E. M. M., Scott, L. V., Shanahan, F., Cryan, J., Cooney, J., & Keeling, P. W. N. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01871.x · Cited by 136 · see citing works

A Pilot Study of Fecal Serine-Protease Activity: A Pathophysiologic Factor in Diarrhea-Predominant Irritable Bowel Syndrome

Róka, R., Rosztoczy, A. I., Leveque, M., Izbéki, F., Nagy, F. T., Molnár, T., Lonovics, J., Villar, R. G., Fioramonti, J., Wittmann, T., et al. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.12.004 · Cited by 132 · see citing works

Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof‐of‐concept study

CORINALDESI, R., STANGHELLINI, V., CREMON, C., GARGANO, L., COGLIANDRO, R. F., DE GIORGIO, R., BARTESAGHI, G., CANOVI, B., & BARBARA, G. (2009) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2009.04041.x · Cited by 131 · see citing works

Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome

Aerssens, J., Camilleri, M., Talloen, W., Thielemans, L., Göhlmann, H. W. H., Van den Wyngaert, I., Thielemans, T., De Hoogt, R., Andrews, C. N., Bharucha, A. E., et al. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.11.012 · Cited by 124 · see citing works

Antibodies to flagellin indicate reactivity to bacterial antigens in IBS patients

Schoepfer, A. M., Schaffer, T., Seibold‐schmid, B., Müller, S., & Seibold, F. (2008) · Neurogastroenterology &amp; Motility · doi:10.1111/j.1365-2982.2008.01166.x · Cited by 120 · see citing works

High rate of gastrointestinal symptoms in celiac patients living on a gluten-free diet: controlled study

Midhagen, G., & Hallert, C. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07632.x · Cited by 109 · see citing works

Symptom overlap and comorbidity of irritable bowel syndrome with other conditions

Frissora, C. L., & Koch, K. L. (2005) · Current Gastroenterology Reports · doi:10.1007/s11894-005-0018-9 · Cited by 100 · see citing works

A Controlled Study of Colonic Immune Activity and β7+ Blood T Lymphocytes in Patients With Irritable Bowel Syndrome

Öhman, L., Isaksson, S., Lundgren, A., Simrén, M., & Sjövall, H. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00410-6 · Cited by 98 · see citing works

Disturbance of function (functio laesa): the legendary fifth cardinal sign of inflammation, added by Galen to the four cardinal signs of Celsus.

Rather, L. J. (1971) · PubMed · Cited by 97 · see citing works

Correlation between cyclical epithelial barrier dysfunction and bacterial translocation in the relapses of intestinal inflammation

Porras, M., Martín, M. T., Yang, P., Jury, J., Perdue, M. H., & Vergara, P. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000231571.88806.62 · Cited by 76 · see citing works

Double‐blind cross‐over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance

LUNARDI, C., BAMBARA, L. M., BIASI, D., CORTINA, P., PEROLI, P., NICOLIS, F., FAVARI, F., & PACOR, M. L. (1991) · Clinical &amp; Experimental Allergy · doi:10.1111/j.1365-2222.1991.tb00848.x · Cited by 72 · see citing works

Human mast cell mediator cocktail excites neurons in human and guinea‐pig enteric nervous system

Schemann, M., Michel, K., CEREGRZYN, M., Zeller, F., Seidl, S., & Bischoff, S. C. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00591.x · Cited by 72 · see citing works

Are There Alterations of Neuroendocrine and Cellular Immune Responses to Nutrients in Women with Irritable Bowel Syndrome?

Elsenbruch, S., Holtmann, G., Oezcan, D., Lysson, A., Janssen, O. E., Goebel, M. U., & Schedlowski, M. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04138.x · Cited by 68 · see citing works

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Bacillus spp. Spores—A Promising Treatment Option for Patients with Irritable Bowel Syndrome

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Chang-Kang-Fang alleviates diarrhea predominant irritable bowel syndrome (IBS-D) through inhibiting TLR4/NF-κB/NLRP3 pathway

Zhang, S., Tian, D., Xia, Z., Yang, F., Chen, Y., Yao, Z., He, Y., Miao, X., Zhou, G., Yao, X., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118236 · Cited by 33 · see citing works

Gut–Brain Axis: Focus on Neurodegeneration and Mast Cells

Conte, C., Sichetti, M., & Traina, G. (2020) · Applied Sciences · doi:10.3390/app10051828 · Cited by 32 · see citing works

Psychological stress‐induced colonic barrier dysfunction: Role of immune‐mediated mechanisms

Hattay, P., Prusator, D. K., Tran, L., & Meerveld, B. G. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13043 · Cited by 30 · see citing works

Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex

Lee, J. Y., Kim, N., Park, J. H., Nam, R. H., Lee, S. M., Song, C., Kim, G., Na, H. Y., Choi, Y. J., Kim, J. J., et al. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm19099 · Cited by 31 · see citing works

Association between Irritable Bowel Syndrome and Allergic Diseases: To Make a Case for Aeroallergen

Loo, E. X. L., Wang, D. Y., & Siah, K. T. H. (2019) · International Archives of Allergy and Immunology · doi:10.1159/000503629 · Cited by 31 · see citing works

Postinfectious Functional Gastrointestinal Disorders

Mearin, F. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31821fbf58 · Cited by 30 · see citing works

The role of diet in the management of irritable bowel syndrome: a focus on FODMAPs

Dolan, R. D., Chey, W. D., & Eswaran, S. L. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1476138 · Cited by 30 · see citing works

IBS clinical management in Italy: The AIGO survey

Soncini, M., Stasi, C., Usai–Satta, P., Milazzo, G., Bianco, M., Leandro, G., Montalbano, L. M., Muscatiello, N., Monica, F., Galeazzi, F., et al. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.10.006 · Cited by 30 · see citing works

Gastrointestinal neuromuscular apparatus: An underestimated target of gut microbiota

Guarino, M. P. L., Cicala, M., Putignani, L., & Severi, C. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i45.9871 · Cited by 29 · see citing works

Neuropsychological function is related to irritable bowel syndrome in women with premenstrual syndrome and dysmenorrhea

Ayadilord, M., Mahmoudzadeh, S., Hoseini, Z. S., Askari, M., Rezapour, H., Saharkhiz, M., Abbaszadeh, A., Karbasi, S., Dasht-e-Bayaz, N. Z., Ferns, G. A., et al. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05659-3 · Cited by 26 · see citing works

Increased fermentable carbohydrate intake alters colonic mucus barrier function through glycation processes and increased mast cell counts

Kamphuis, J. B. J., Reber, L. L., Eutamène, H., & Théodorou, V. (2022) · The FASEB Journal · doi:10.1096/fj.202100494rrr · Cited by 27 · see citing works

Repeated Water Avoidance Stress Alters Mucosal Mast Cell Counts, Interleukin-1β Levels with Sex Differences in the Distal Colon of Wistar Rats

Lee, J. Y., Kim, N., Kim, Y. S., Nam, R. H., Ham, M. H., Lee, H. S., Jo, W., Shim, Y. K., Choi, Y. J., Yoon, H., et al. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16007 · Cited by 27 · see citing works

A Randomized Clinical Trial of Synbiotics in Irritable Bowel Syndrome: Dose-Dependent Effects on Gastrointestinal Symptoms and Fatigue

Lee, S.-H., Cho, D., Lee, S., Han, K.-S., Yang, S.-W., Kim, J.-H., Lee, S.-H., Kim, S.-M., & Kim, K.-N. (2018) · Korean Journal of Family Medicine · doi:10.4082/kjfm.17.0064 · Cited by 27 · see citing works

Relationship Between Systemic Immune-Inflammation Index and Irritable Bowel Syndrome

Güven, İ. E., Başpınar, B., & Atalay, R. (2022) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2021.21321 · Cited by 26 · see citing works

The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abuelazm, M. T., Shoaib, M., Gamal, M., Labieb, F., Amin, M. A., Abdelazeem, B., & Brašić, J. R. (2022) · Nutrients · doi:10.3390/nu14132618 · Cited by 26 · see citing works

The role of intestinal mast cell infiltration in irritable bowel syndrome

Cheng, L., Luo, Q., & Chen, S. (2021) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12971 · Cited by 25 · see citing works

Role of microRNAs in Disorders of Gut–Brain Interactions: Clinical Insights and Therapeutic Alternatives

Singh, R., Zogg, H., & Ro, S. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11101021 · Cited by 25 · see citing works

Oligo-Antigenic Diet in the Treatment of Chronic Anal Fissures. Evidence for a Relationship Between Food Hypersensitivity and Anal Fissures

Carroccio, A., Mansueto, P., Morfino, G., D’Alcamo, A., Paola, V. D., Iacono, G., Soresi, M., Scerrino, G., Maresi, E., Gulotta, G., et al. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.58 · Cited by 25 · see citing works

Association between gastrointestinal motility and macrophage/mast cell distribution in mice during the healing stage after DSS‑induced colitis

Kodani, M., Fukui, H., Tomita, T., Oshima, T., Watari, J., & Miwa, H. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8926 · Cited by 23 · see citing works

Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids

Dhonnabháín, R. N., Xiao, Q., & O’Malley, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.745190 · Cited by 22 · see citing works

Role of inflammation in pediatric irritable bowel syndrome

Nardo, G. D., Cremon, C., Staiano, A., Stanghellini, V., Borrelli, O., Strisciuglio, C., Romano, C., Mallardo, S., Scarpato, E., Marasco, G., et al. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14365 · Cited by 21 · see citing works

Factor V Leiden and Inflammation

Pérez‐Pujol, S., Aras, Ö., & Escolar, G. (2012) · Thrombosis · doi:10.1155/2012/594986 · Cited by 21 · see citing works

The Protective Effect of Roseburia faecis Against Repeated Water Avoidance Stress-induced Irritable Bowel Syndrome in a Wister Rat Model

Choi, S. I., Kim, N., Nam, R. H., Jang, J. Y., Kim, E. H., Ha, S., Kang, K. S., Lee, W., Choi, H., Kim, Y.-R., et al. (2023) · Journal of Cancer Prevention · doi:10.15430/jcp.2023.28.3.93 · Cited by 20 · see citing works

Multi-target Treatment for Irritable Bowel Syndrome with STW 5: Pharmacological Modes of Action

Allescher, H., Burgell, R., Malfertheiner, P., & Mearin, F. (2020) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-814 · Cited by 19 · see citing works

Stem Cells in the Intestine: Possible Roles in Pathogenesis of Irritable Bowel Syndrome

Ratanasirintrawoot, S., & Israsena, N. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16023 · Cited by 19 · see citing works

Functional Gastrointestinal Disorders

Duffy, M., Boggiano, V. L., Ganesh, R., & Mueller, M. (2023) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2023.03.006 · Cited by 20 · see citing works

Low prevalence of ‘classical’ microscopic colitis but evidence of microscopic inflammation in Asian Irritable Bowel Syndrome patients with diarrhoea

Hilmi, I. N., Hartono, J. L., Pailoor, J., Mahadeva, S., & Goh, K. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-80 · Cited by 18 · see citing works

Review The Immune System in Irritable Bowel Syndrome

Barbara, G., Cremon, C., Carini, G., Bellacosa, L., Zecchi, L., Giorgio, R. D., Corinaldesi, R., & Stanghellini, V. (2013)

Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?

Hughes, P. A., Zola, H., Penttila, I., Blackshaw, L. A., Andrews, J. M., & Krumbiegel, D. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.120 · Cited by 147 · see citing works

Pathogenesis of Irritable Bowel Syndrome - Review Regarding Associated Infection and Immune Activation

Ishihara, S., Tada, Y., Fukuba, N., Oka, A., Kusunoki, R., Mishima, Y., Oshima, N., Moriyama, I., Yuki, T., Kawashima, K., et al. (2013) · Digestion · doi:10.1159/000350054 · Cited by 51 · see citing works

Antiflagellin antibodies suggest infective participation in irritable bowel syndrome pathogenesis

Cremon, C., Pallotti, F., Bacchilega, M., Stanghellini, V., Corinaldesi, R., & Barbara, G. (2008) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2.6.735 · Cited by 10 · see citing works

Immune activation in irritable bowel syndrome: what is the evidence?

Aguilera‐Lizarraga, J., Hussein, H., & Boeckxstaens, G. E. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00700-9 · Cited by 109 · see citing works