Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study)
Open accessAbstract
BACKGROUND: The management of cardiovascular risk factors is important for prevention of atherosclerotic cardiovascular diseases (ACVD). Visceral fat accumulation plays an important role in the clustering of cardiovascular risk factors, leading to ACVD. The present study investigated the gender- and age-specific relationship between obesity-related cardiovascular risk factor accumulation and computed tomography (CT)-measured fat distribution in a large-scale Japanese general population. METHODS AND RESULTS: Fat distribution was measured on CT scans in 12,443 subjects (males/females = 10,080/2,363), who underwent medical health check-up at 9 centers in Japan. The investigated obesity-related cardiovascular risk factors were hyperglycemia, dyslipidemia, and elevated blood pressure. Visceral fat area (VFA) for all males and old females showed almost symmetric distribution, while that of young females showed skewed distribution with a marked left shift. Only a small proportion of young females had large visceral fat and cardiovascular risk accumulation. The mean number of risk factors exceeded 1.0 at around 100 cm(2) for VFA in all groups, irrespective of gender, age (cut-off age 55), and BMI (cut-off BMI 25 kg/m(2)). CONCLUSIONS: In this large-scale Japan-wide general population study, an absolute VFA value of about 100 cm(2) equated with obesity-related cardiovascular risk factor accumulation, irrespective of gender, age, and BMI.
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The difference between the diagnostic criteria in Japan and the joint statement by Western academic societies is whether they are based on visceral fat accumulation or not.
“The difference between the diagnostic criteria in Japan and the joint statement by Western academic societies329) is whether they are based on visceral fat accumulation or not.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [329]
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- Authors
- Hiuge-Shimizu, A., Kishida, K., Funahashi, T., Ishizaka, Y., Oka, R., Okada, M., Suzuki, S., Takaya, N., Nakagawa, T., Fukui, T., Fukuda, H., Watanabe, N., Yoshizumi, T., Nakamura, T., Matsuzawa, Y., Yamakado, M., & Shimomura, I.
- Affiliations
- The University of Osaka (JP)
- Mitsui Memorial Hospital (JP)
- Kameda Medical Center (JP)
- Hitachi (Japan) (JP)
- NTT (Japan) (JP)
- Juntendo University (JP)
- Yodogawa Christian Hospital (JP)
- Kawasaki Hospital (JP)
- Corresponding author
- Kishida, Ken
- ORCID
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2010-10-22
- Volume
- 44
- Issue
- 1
- Pages
- 82-92
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2086838979
- Cited by
- 205
- References
- 32
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 15 · 2023: 27 · 2022: 14 · 2021: 21 · 2020: 22 · 2019: 13 · 2018: 15 · 2017: 5 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 11 · 2012: 7
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- visceral fat area, cardiovascular risk factors, obesity, body fat distribution, hyperglycemia, dyslipidemia, elevated blood pressure, atherosclerotic cardiovascular disease, sex differences, age differences, body mass index, reference values
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Body Composition, Female, Humans, Japan, Male, Middle Aged, Obesity, Retrospective Studies, Risk Factors, Sex Factors, Tomography, X-Ray Computed, Body Mass Index, Asian People, Subcutaneous Fat, Intra-Abdominal Fat, Atherosclerosis, Young Adult
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