Cited by 49Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsRegulation of Appetite and Obesity

Inverse relationship between serum Metrnl levels and visceral fat obesity (VFO) in patients with type 2 diabetes

Du, Yunfeng, Ye, Xinhua, Lu, Aijiao, Zhao, Dan, Liu, Juan, Cheng, Jinluo, Yang, Tao·2020·Diabetes Research and Clinical Practice

Abstract

Aim The relationship between serum Metrnl levels and visceral fat obesity (VFO) remains unclear. This study aimed to investigate the association between serum Metrnl levels and VFO in Chinese patients with type 2 diabetes.Methods A total of 321 Chinese patients with type 2 diabetes (226 men and 95 postmenopausal women aged 61.4 ± 6.5 years, BMI 25.1 ± 3.2 kg/m 2) were evaluated. Serum Metrnl levels were measured by enzyme linked-immunosorbent assay. Visceral fat area (VFA) was quantified via Dual Energy X-ray Absorptiometry (DXA). Correlation analyses were carried out for serum Metrnl levels and VFO.Results VFO groups (VFA ≧100 cm 2) have lower serum Metrnl levels than non-VFO groups (VFA < 100 cm 2) (578.9 ± 225.1 vs. 684.9 ± 263.8, P = 0.001). An increasing trend in serum Metrnl levels was found to accompany the decrease in VFA. Serum Metrnl levels were negatively correlated with VFA, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and albumin (ALB), but positively correlated with age, height, blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) (all P < 0.05). Binary logistic regression analysis showed that serum Metrnl was inversely associated with VFO even after adjusted age, gender, height, TC, TG, LDL-C, ALB, BUN, Cr, and UA (odds ration [OR], 0.846; confidence interval [CI], 0.745-0.961; P = 0.010). The optimal cut-off value of serum Metrnl levels that predicted VFO was 671.3 ng/ml (95%CI = 0.55-0.70, P = 0.001).Conclusions Serum Metrnl levels were inversely correlated with VFO and may be a useful indicator of VFO in Chinese patients with type 2 diabetes.

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Crossref · 10.1016/j.diabres.2020.108068

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Authors
Du, Y., Ye, X., Lu, A., Zhao, D., Liu, J., Cheng, J., & Yang, T.
Affiliations
  • Changzhou No.2 People's Hospital (CN)
  • Jiangsu Province Hospital (CN)
Corresponding author
  • Cheng, Jinluo
  • Yang, Tao
Venue
Diabetes Research and Clinical Practice
Publisher
Elsevier BV
Published
2020-03
Volume
161
Pages
108068
ISSN
0168-8227 (ISSN-L)
OpenAlex
W3004940514
Cited by
49
References
20
Citations by year
2026: 3 · 2025: 15 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 6
FWCI
4.12
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Research and Clinical Practice (publishedVersion)
  • PubMed (publishedVersion)
Funders
Scientific Grant (CZ20150017)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
Metrnl, visceral fat obesity, type 2 diabetes, visceral fat area, serum biomarkers, obesity prediction, Chinese patients, lipid profile, uric acid
MeSH terms
Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Intra-Abdominal Fat, Adipokines, Obesity, Abdominal

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