Long-term consequences of maternal overweight in pregnancy on offspring later health: Findings from the Helsinki Birth Cohort Study
Open accessAbstract
INTRODUCTION: Obesity has reached epidemic proportions worldwide. Maternal obesity has consequences for the offspring's later health. Only few studies have focused upon the long-term consequences of maternal obesity on the offspring's later health. METHODS: A total of 13,345 men and women born in Helsinki during 1934-44 belonging to the Helsinki Birth Cohort Study were included in the study. Data on maternal weight and height in late pregnancy were available from hospital records. Using validated national registers we report on the following outcomes in relation to maternal BMI: death, cancer, coronary heart disease, stroke, and diabetes among the offspring. RESULTS: Maternal BMI was positively associated with each of the later health outcomes of the offspring. The associations were strongest for cardiovascular disease and type 2 diabetes. The association with type 2 diabetes was stronger in women. DISCUSSION: Our findings stress the importance of early prevention of overweight and obesity in women of child-bearing age.
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Individuals exposed to maternal obesity or GDM in utero are, as adults, more likely to die as a result of cardiovascular disease.
“Individuals who are exposed to maternal obesity or GDM in utero are, as adults, more likely to be obese, 93 develop type‐2 diabetes 94 , 95 and die as a result of cardiovascular disease. 96”
From Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review (2022) · cites this paper as [96]
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- Authors
- Eriksson, J. G., Sandboge, S., Salonen, M. K., Kajantie, E., & Osmond, C.
- Affiliations
- University of Helsinki (FI)
- Southampton General Hospital (GB)
- Corresponding author
- Eriksson, Johan G.
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2014-06-09
- Volume
- 46
- Issue
- 6
- Pages
- 434-438
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2159395295
- Cited by
- 213
- References
- 4
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 23 · 2023: 14 · 2022: 24 · 2021: 19 · 2020: 17 · 2019: 25 · 2018: 20 · 2017: 15 · 2016: 20 · 2015: 11 · 2014: 2
- FWCI
- 15.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- European Commission (278603)
- Signe ja Ane Gyllenbergin Säätiö
- Novo Nordisk Fonden (NNF12OC1016374)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- maternal obesity, maternal body mass index, offspring health, type 2 diabetes, cardiovascular disease, coronary artery disease, stroke, cancer, mortality, long-term health effects, Helsinki Birth Cohort Study, women of child-bearing age
- MeSH terms
- Adult, Coronary Disease, Diabetes Mellitus, Type 2, Female, Finland, Humans, Longitudinal Studies, Male, Neoplasms, Obesity, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Risk Factors, Socioeconomic Factors, Stroke
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