Sex differences in the developmental origins of cardiometabolic disease following exposure to maternal obesity and gestational diabetes
Open accessAbstract
Over the past 30 years, the worldwide prevalence of obesity has nearly doubled. In addition, more and more women in their child-bearing years are overweight or obese, which increases the risk of gestational diabetes mellitus (GDM). It is increasingly accepted by the scientific community that early life exposure to environmental stress influences the long-term health of an individual, which has been termed the Developmental Origins of Health and Disease theory. Evidence from human cohorts and epidemiological and animal studies has shown that maternal obesity and GDM condition the offspring for cardiometabolic disease development. These effects are most likely regulated by epigenetic mechanisms; however, biological sex is an important factor in defining the risk of the development of several metabolic health disorders. The aim of this review is to describe the current evidence from human cohort and animal model studies that implicates sex differences in the developmental origins of cardiometabolic disease following exposure to maternal obesity and GDM. In addition, this review addresses the potential mechanisms involved in these sex differences. In many studies, sex is ignored as an important variable in disease development; however, the results presented in this review highlight important differences between sexes in the developmental programming of biological responses to exposures during the fetal stage. This knowledge will ultimately help in the development of effective therapeutic strategies for the treatment of cardiometabolic diseases that exhibit sexual dimorphism.
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Evidence is mounting that altered fetal growth and development, as well as lifelong perturbations in metabolic tissues, are also associated with exposure to overnutrition and metabolic disorders in early life.
“Evidence is mounting that altered fetal growth and development, as well as lifelong perturbations in metabolic tissues, are also associated with exposure to overnutrition and metabolic disorders in early life (reviewed in [37,44,45]).”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [45]
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“Evidence is mounting that altered fetal growth and development, as well as lifelong perturbations in metabolic tissues, are also associated with exposure to overnutrition and metabolic disorders in early life (reviewed in [37,44,45]).”
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- Authors
- Talbot, C. P. J., & Dolinsky, V. W.
- Affiliations
- Children's Hospital Research Institute of Manitoba (CA)
- Venue
- Applied Physiology, Nutrition, and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2019-07
- Volume
- 44
- Issue
- 7
- Pages
- 687-695
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W2903148443
- Cited by
- 29
- References
- 84
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 7 · 2020: 1
- FWCI
- 0.05
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Applied Physiology Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (acceptedVersion)
- Funders
- Manitoba Medical Service Foundation
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- sex differences, developmental origins of health and disease, cardiometabolic disease, maternal obesity, gestational diabetes mellitus, fetal programming, epigenetics, sexual dimorphism, offspring metabolic risk
- MeSH terms
- Pregnancy in Obesity, Obesity, Maternal, Adult, Cardiovascular Diseases, Female, Humans, Infant, Newborn, Male, Metabolic Diseases, Obesity, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Sex Characteristics, Body Mass Index, Diabetes, Gestational
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