Prenatal Exposure to a Maternal High-Fat Diet Affects Histone Modification of Cardiometabolic Genes in Newborn Rats
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Infants born to women with diabetes or obesity are exposed to excess circulating fuels during fetal heart development and are at higher risk of cardiac diseases. We have previously shown that late-gestation diabetes, especially in conjunction with a maternal high-fat (HF) diet, impairs cardiac functions in rat-offspring. This study investigated changes in genome-wide histone modifications in newborn hearts from rat-pups exposed to maternal diabetes and HF-diet. Chromatin-immunoprecipitation-sequencing revealed a differential peak distribution on gene promoters in exposed pups with respect to acetylation of lysines 9 and 14 and to trimethylation of lysines 4 and 27 in histone H3 (all, false discovery rate, FDR < 0.1). In the HF-diet exposed offspring, 54% of the annotated genes showed the gene-activating mark trimethylated lysine 4. Many of these genes (1) are associated with the “metabolic process” in general and particularly with “positive regulation of cholesterol biosynthesis” (FDR = 0.03); (2) overlap with 455 quantitative trait loci for blood pressure, body weight, serum cholesterol (all, FDR < 0.1); and (3) are linked to cardiac disease susceptibility/progression, based on disease ontology analyses and scientific literature. These results indicate that maternal HF-diet changes the cardiac histone signature in offspring suggesting a fuel-mediated epigenetic reprogramming of cardiac tissue in utero.
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Similar to the transcriptomic profile, genes involved in metabolic processes were highly represented.
“Similar to the transcriptomic profile, genes involved in metabolic processes were highly represented.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [124]
Results §3.4 reports several genes associated with metabolic processes among those with differential histone-mark binding. But it says only genes with a gene-ontology hit for “metabolic process” are reported there, so that selection does not establish that such genes were highly represented overall. The paper also does not compare this finding with a transcriptomic profile. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThese changes in gene expression could be a consequence of alterations in epigenetic marks that regulate gene expression.
“These changes could be a consequence of alterations in epigenetic marks that regulate gene expression.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [124]
Chromatin-immunoprecipitation sequencing revealed increases in the gene-repressive histone 3 trimethylated lysine-27 mark.
“For example, chromatin-immunoprecipitation sequencing revealed increases in the gene-activating mark of histone-3 trimethylated lysine 4, but also the gene-repressive histone 3 trimethylated lysine-27 mark [124].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [124]
Chromatin-immunoprecipitation sequencing revealed increases in the gene-activating mark of histone-3 trimethylated lysine 4.
“For example, chromatin-immunoprecipitation sequencing revealed increases in the gene-activating mark of histone-3 trimethylated lysine 4, but also the gene-repressive histone 3 trimethylated lysine-27 mark [124].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [124]
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- Authors
- Upadhyaya, B., Larsen, T., Barwari, S., Louwagie, E., Baack, M., & Dey, M.
- Affiliations
- South Dakota State University (US)
- Sanford Research (US)
- University of South Dakota (US)
- Corresponding author
- Baack, Michelle
- Dey, Moul
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-04-20
- Volume
- 9
- Issue
- 4
- Pages
- 407
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5409746
- OpenAlex
- W2607367045
- Cited by
- 40
- References
- 72
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 9 · 2019: 6 · 2017: 1
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (K08HD078504)
- National Institute of Food and Agriculture (1004817)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- maternal high-fat diet, maternal diabetes, prenatal exposure, histone modifications, newborn heart, H3K4 trimethylation, H3K9 acetylation, H3K27me3, epigenetic reprogramming, cholesterol biosynthesis, quantitative trait loci, fetal heart development
- MeSH terms
- Animals, Animals, Newborn, Blood Pressure, Body Weight, Cardiovascular Diseases, Cholesterol, Diabetes Mellitus, Experimental, Female, Pregnancy, Prenatal Exposure Delayed Effects, Promoter Regions, Genetic, Rats, Sprague-Dawley, Sequence Analysis, DNA, Gene Expression Regulation, Developmental, Genetic Predisposition to Disease, Metabolic Syndrome, Maternal Nutritional Physiological Phenomena, Quantitative Trait Loci, Histone Code, Epigenesis, Genetic, Fetal Development, Rats, Genetic Association Studies, Diet, High-Fat
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