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Anti-inflammatory and immunomodulatory effects of Spirulina platensis in comparison to Dunaliella salina in acetic acid-induced rat experimental colitis
Abstract
CONTEXT: Spirulina platensis (SP) is used as a source of protein and vitamin supplement in humans without any significant side-effects. Dunaliella salina (DS) is also regarded as one of the richest natural producers of carotenoid, thus used as a source of antioxidants to protect cells from oxidative damage. OBJECTIVE: The aim of the present study is to compare the ameliorative effect of Spirulina and Dunaliella in experimental colitis. MATERIALS AND METHODS: Spirulina and Dunaliella were investigated at the same dose of 500 mg/kg body weight for their modulatory effect against acetic-acid induced ulcerative colitis (UC) in rats. The colonic lesion was analyzed by examining macroscopic damage, bloody diarrhea scores, colon weight/length and change in body weight of tested rats. Colon lipid peroxidation and oxidative stress markers were examined by evaluating malondialdehyde (MDA), protein carbonyl (PCO), catalase (CAT), reduced glutathione (GSH) and superoxide dismutase (SOD). Colon inflammatory markers; myeloperoxidase (MPO) and prostaglandin (PGE2) as well as proinflammatory cytokines; tumor necrosis factor (TNF-α) and interleukins (IL-1β, IL-6) were also studied. RESULTS: The colonic mucosal injury, biochemical and histopathologic results suggest that both SP and DS exhibit significant modulatory effect on acetic acid-induced colitis in rats, which may be due to a significant increase of antioxidant enzymes activity and significant inhibition of lipid peroxidation and inflammation markers. DISCUSSION: Results showed that in comparison to Sulfasalazine, SP exhibited better therapeutic and safety profile than DS against acetic acid-induced UC. CONCLUSION: This study suggests potential benefits of SP and DS in an experimental model of colitis.
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“In rat models of experimental colitis (acetic-acid induced) [48] and arthritis (Freund's adjuvant-induced [49] and collagen-induced [50]) the antioxidant activity of Spirulina was associated with anti-inflammatory effects.”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly Spirulina (2017) · cites this paper as [48]
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Metadata
- Authors
- Abdel-Daim, M. M., Farouk, S. M., Madkour, F. F., & Azab, S. S.
- Affiliations
- Suez Canal University (EG)
- Port Said University (EG)
- Ain Shams University (EG)
- Corresponding author
- Azab, Samar S.
- Venue
- Immunopharmacology and Immunotoxicology
- Publisher
- Informa UK Limited
- Published
- 2015-01-08
- Volume
- 37
- Issue
- 2
- Pages
- 126-139
- ISSN
- 0892-3973 (ISSN-L)
- 1532-2513
- OpenAlex
- W2022830601
- Cited by
- 164
- References
- 57
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 13 · 2023: 12 · 2022: 19 · 2021: 27 · 2020: 14 · 2019: 11 · 2018: 19 · 2017: 11 · 2016: 8 · 2015: 6
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunopharmacology and Immunotoxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- Spirulina platensis, Dunaliella salina, ulcerative colitis, acetic acid-induced colitis, anti-inflammatory activity, immunomodulation, oxidative stress, lipid peroxidation, antioxidant enzymes, inflammatory cytokines, sulfasalazine, green microalgae
- MeSH terms
- Animals, Anti-Inflammatory Agents, Colitis, Ulcerative, Immunologic Factors, Male, Plant Extracts, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Acetic Acid, Solanaceae, Rats, Spirulina
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