Cited by 164Inflammatory Bowel DiseaseSeaweed-derived Bioactive CompoundsAntioxidant Activity and Oxidative Stress

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Anti-inflammatory and immunomodulatory effects of Spirulina platensis in comparison to Dunaliella salina in acetic acid-induced rat experimental colitis

Abdel-Daim, Mohamed M., Farouk, Sameh M., Madkour, Fedekar F., Azab, Samar S.·2015·Immunopharmacology and Immunotoxicology

DOI 10.3109/08923973.2014.998368

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Abstract

CONTEXT: Spirulina platensis (SP) is used as a source of protein and vitamin supplement in humans without any significant side-effects. Dunaliella salina (DS) is also regarded as one of the richest natural producers of carotenoid, thus used as a source of antioxidants to protect cells from oxidative damage. OBJECTIVE: The aim of the present study is to compare the ameliorative effect of Spirulina and Dunaliella in experimental colitis. MATERIALS AND METHODS: Spirulina and Dunaliella were investigated at the same dose of 500 mg/kg body weight for their modulatory effect against acetic-acid induced ulcerative colitis (UC) in rats. The colonic lesion was analyzed by examining macroscopic damage, bloody diarrhea scores, colon weight/length and change in body weight of tested rats. Colon lipid peroxidation and oxidative stress markers were examined by evaluating malondialdehyde (MDA), protein carbonyl (PCO), catalase (CAT), reduced glutathione (GSH) and superoxide dismutase (SOD). Colon inflammatory markers; myeloperoxidase (MPO) and prostaglandin (PGE2) as well as proinflammatory cytokines; tumor necrosis factor (TNF-α) and interleukins (IL-1β, IL-6) were also studied. RESULTS: The colonic mucosal injury, biochemical and histopathologic results suggest that both SP and DS exhibit significant modulatory effect on acetic acid-induced colitis in rats, which may be due to a significant increase of antioxidant enzymes activity and significant inhibition of lipid peroxidation and inflammation markers. DISCUSSION: Results showed that in comparison to Sulfasalazine, SP exhibited better therapeutic and safety profile than DS against acetic acid-induced UC. CONCLUSION: This study suggests potential benefits of SP and DS in an experimental model of colitis.

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Authors: Abdel-Daim, M. M., Farouk, S. M., Madkour, F. F., & Azab, S. S.
Affiliations: Suez Canal University (EG)
Port Said University (EG)
Ain Shams University (EG)
Corresponding author: Azab, Samar S.
ORCID: Farouk, Sameh M.
Madkour, Fedekar F.
Azab, Samar S.
Venue: Immunopharmacology and Immunotoxicology
Publisher: Informa UK Limited
Published: 2015-01-08
Volume: 37
Issue: 2
Pages: 126-139
ISSN: 0892-3973 (ISSN-L)
1532-2513
DOI: 10.3109/08923973.2014.998368
OpenAlex: W2022830601
Cited by: 164
References: 57
Citations by year: 2026: 10 · 2025: 14 · 2024: 13 · 2023: 12 · 2022: 19 · 2021: 27 · 2020: 14 · 2019: 11 · 2018: 19 · 2017: 11 · 2016: 8 · 2015: 6
FWCI: 10.02
Type: journal article
Language: en
Open access: closed
Locations: Immunopharmacology and Immunotoxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: Spirulina platensis, Dunaliella salina, ulcerative colitis, acetic acid-induced colitis, anti-inflammatory activity, immunomodulation, oxidative stress, lipid peroxidation, antioxidant enzymes, inflammatory cytokines, sulfasalazine, green microalgae
MeSH terms: Animals, Anti-Inflammatory Agents, Colitis, Ulcerative, Immunologic Factors, Male, Plant Extracts, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Acetic Acid, Solanaceae, Rats, Spirulina

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Anti-inflammatory and immunomodulatory effects of Spirulina platensis in comparison to Dunaliella salina in acetic acid-induced rat experimental colitis

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