The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Anti-inflammatory and immunomodulatory effects of Spirulina platensis in comparison to Dunaliella salina in acetic acid-induced rat experimental colitis
Abstract
CONTEXT: Spirulina platensis (SP) is used as a source of protein and vitamin supplement in humans without any significant side-effects. Dunaliella salina (DS) is also regarded as one of the richest natural producers of carotenoid, thus used as a source of antioxidants to protect cells from oxidative damage. OBJECTIVE: The aim of the present study is to compare the ameliorative effect of Spirulina and Dunaliella in experimental colitis. MATERIALS AND METHODS: Spirulina and Dunaliella were investigated at the same dose of 500 mg/kg body weight for their modulatory effect against acetic-acid induced ulcerative colitis (UC) in rats. The colonic lesion was analyzed by examining macroscopic damage, bloody diarrhea scores, colon weight/length and change in body weight of tested rats. Colon lipid peroxidation and oxidative stress markers were examined by evaluating malondialdehyde (MDA), protein carbonyl (PCO), catalase (CAT), reduced glutathione (GSH) and superoxide dismutase (SOD). Colon inflammatory markers; myeloperoxidase (MPO) and prostaglandin (PGE2) as well as proinflammatory cytokines; tumor necrosis factor (TNF-α) and interleukins (IL-1β, IL-6) were also studied. RESULTS: The colonic mucosal injury, biochemical and histopathologic results suggest that both SP and DS exhibit significant modulatory effect on acetic acid-induced colitis in rats, which may be due to a significant increase of antioxidant enzymes activity and significant inhibition of lipid peroxidation and inflammation markers. DISCUSSION: Results showed that in comparison to Sulfasalazine, SP exhibited better therapeutic and safety profile than DS against acetic acid-induced UC. CONCLUSION: This study suggests potential benefits of SP and DS in an experimental model of colitis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In rat models of experimental colitis (acetic-acid induced) [48] and arthritis (Freund's adjuvant-induced [49] and collagen-induced [50]) the antioxidant activity of Spirulina was associated with anti-inflammatory effects.”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly Spirulina (2017) · cites this paper as [48]
Citations
Cites
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696
Theory and Practice of Histological Techniques
Bancroft, J. D., & Gamble, M. (1990) · Cited by 6,948
Improved method for the determination of blood glutathione.
Beutler, E., Duron, O., & KELLY, B. M. (1963) · PubMed · Cited by 6,932
[49] Determination of carbonyl content in oxidatively modified proteins
Levine, R. L., Garland, D. L., Oliver, C. N., Amici, A., Climent, I., Lenz, A.-G., Ahn, B. W., Shaltiel, S., & Stadtman, E. R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86141-h · Cited by 5,895
Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
Uchiyama, M., & Mihara, M. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90342-1 · Cited by 5,207
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245
Nishikimi, M., Rao, N. A., & Yagi, K. (1972) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(72)80218-3 · Cited by 4,091
Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183
Loftus, E. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.063 · Cited by 3,106
Research works printed but not linked: 5
- Ibrahim A, Abdel Daim M. Modulating effects ofSpirulina platensisagainst tilmicosin-induced cardiotoxicity in mice. Cell Journal (Yakhteh) 2015;17. (in press)
- Madkour FF, 2013, Indian J Pharm Sci, 75, 642
- Beutler E, 1963, J Lab Clin Med, 61, 882
- Krawisz JE, 1984, Assessment of inflammation in rat and hamster models. Gastroenterology, 87, 1344
- Celinski K, 2011, J Physiol Pharmacol, 62, 347
Cited by
Sorted by citations
The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: An overview
Wu, Q., Liu, L., Miron, A., Klímová, B., Wan, D., & Kuča, K. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1744-5 · Cited by 655
Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?
Moura, F. A., de Andrade, K. Q., dos Santos, J. C. F., de Araújo, O. R. P., & Goulart, M. O. F. (2015) · Redox Biology · doi:10.1016/j.redox.2015.10.006 · Cited by 388
Finamore, A., Palmery, M., Bensehaila, S., & Peluso, I. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3247528 · Cited by 256
Park, W. S., Kim, H.-J., Li, M., Lim, D.-H., Kim, J., Kwak, S.-S., Kang, C.-M., Ferruzzi, M. G., & Ahn, M.-J. (2018) · doi:10.20944/preprints201807.0470.v1 · Cited by 232
Abdel‐Moneim, A. E., Shehata, A. M., Mohamed, N. G., Elbaz, A. M., & Ibrahim, N. S. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02662-w · Cited by 132
Metadata
- Authors
- Abdel-Daim, M. M., Farouk, S. M., Madkour, F. F., & Azab, S. S.
- Affiliations
- Suez Canal University (EG)
- Port Said University (EG)
- Ain Shams University (EG)
- Corresponding author
- Azab, Samar S.
- Venue
- Immunopharmacology and Immunotoxicology
- Publisher
- Informa UK Limited
- Published
- 2015-01-08
- Volume
- 37
- Issue
- 2
- Pages
- 126-139
- ISSN
- 0892-3973 (ISSN-L)
- 1532-2513
- OpenAlex
- W2022830601
- Cited by
- 164
- References
- 57
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 13 · 2023: 12 · 2022: 19 · 2021: 27 · 2020: 14 · 2019: 11 · 2018: 19 · 2017: 11 · 2016: 8 · 2015: 6
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunopharmacology and Immunotoxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- Spirulina platensis, Dunaliella salina, ulcerative colitis, acetic acid-induced colitis, anti-inflammatory activity, immunomodulation, oxidative stress, lipid peroxidation, antioxidant enzymes, inflammatory cytokines, sulfasalazine, green microalgae
- MeSH terms
- Animals, Anti-Inflammatory Agents, Colitis, Ulcerative, Immunologic Factors, Male, Plant Extracts, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Acetic Acid, Solanaceae, Rats, Spirulina
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
