Diet, physical exercise and Orlistat administration increase serum Anti-Müllerian Hormone (AMH) levels in women with polycystic ovary syndrome (PCOS)
Abstract
The present study investigates the combined effect of diet, physical exercise and Orlistat for 24 weeks, on serum anti-Müllerian hormone (AMH) levels in overweight and obese women with polycystic ovary syndrome (PCOS) and in overweight and obese controls. Sixty-one (61) selected women with PCOS and 20 overweight and obese controls followed an energy-restricted diet, physical exercise plus Orlistat administration (120 mg, 3 times per day) for 24 weeks. At baseline, week 12 and week 24, serum levels of AMH, FSH, LH, PRL, androgens, sex hormone-binding globulin (SHBG), glucose, and insulin were measured and Free Androgen Index (FAI) and Insulin Resistance (IR) indices were calculated. In PCOS women, serum AMH levels increased after 12 and 24 weeks of treatment. After 12 weeks LH and SHBG were increased, while Testosterone decreased. After 12 and 24 weeks, FAI was decreased and all indices of IR were significantly improved. We concluded that in overweight and obese women with PCOS Orlistat administration, combined with diet and physical exercise, for 24 weeks, resulted in significant weight loss, improvement of hyperandrogenism and insulin sensitivity, and increased serum AMH levels.
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Weight loss through lifestyle modification, medications, or bariatric surgery improves insulin resistance, reduces hyperandrogenism, and alleviates PCOS clinical severity.
“Consistently, weight loss through lifestyle modification (comprising dietary modification, physical activity and/or behavioural change), medications (metformin, orlistat, incretin mimetics) orbariatric surgery improves insulin resistance, reduces hyperandrogenism and alleviates PCOS clinical severity (Moran et al. , 2011; Vosnakis et al. , 2013; Jensterle et al. , 2015).”
From Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis (2015) · cites this paper as Vosnakis et al., 2013
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Fat Tissue: A Steroid Reservoir and Site of Steroid Metabolism
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Naderpoor, N., Shorakae, S., de Courten, B., Misso, M. L., Moran, L. J., & Teede, H. J. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv025 · Cited by 334 · see citing works
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Weight management interventions in women with and without PCOS: a systematic review
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Self-citationWeight management strategies for patients with PCOS: current perspectives
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- Authors
- Vosnakis, C., Georgopoulos, N. A., Rousso, D., Mavromatidis, G., Katsikis, I., Roupas, N. D., Mamali, I., & Panidis, D.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- University of Patras (GR)
- Corresponding author
- Georgopoulos, Neoklis A.
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2012-11-30
- Volume
- 29
- Issue
- 3
- Pages
- 242-245
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2046541439
- Cited by
- 48
- References
- 5
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 3
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- polycystic ovary syndrome, anti-Müllerian hormone, orlistat, hypocaloric diet, physical activity, obesity, overweight women, insulin resistance, hyperandrogenism, free androgen index, sex hormone-binding globulin, weight loss, testosterone, luteinizing hormone, follicle-stimulating hormone
- MeSH terms
- Orlistat, Adult, Combined Modality Therapy, Diet, Reducing, Female, Humans, Insulin Resistance, Lactones, Luteinizing Hormone, Obesity, Polycystic Ovary Syndrome, Testosterone, Weight Loss, Exercise, Up-Regulation, Body Mass Index, Hyperandrogenism, Anti-Obesity Agents, Overweight, Anti-Mullerian Hormone, Young Adult
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