The Effects of Dietary Approaches to Stop Hypertension Diet on Weight Loss, Anti-Müllerian Hormone and Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Randomized Clinical Trial
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Summary: Objective: This study was designed to evaluate the effects of the dietary approaches to stop hypertension ( DASH diet) on weight loss, anti‐Müllerian hormone ( AMH ) and metabolic profiles in women with polycystic ovary syndrome ( PCOS ). Design, Patients and Measurements: A randomized controlled clinical trial was conducted among 60 overweight or obese patients with PCOS . Patients were randomly assigned to receive either low‐calorie DASH (N=30) or control diet (N=30) for 12 weeks. The DASH and control diets were consisted of 52%‐55% carbohydrates, 16%‐18% proteins and 30% total fats; however, the DASH diet was designed to be rich in fruits, vegetables, whole grains, low‐fat dairy products, cholesterol and refined grains. Both diets were equicaloric. Results: Adherence to the DASH diet, compared to the control diet, resulted in a significant decrease in BMI (−1.6±0.5 vs −1.2±0.7 kg/m 2 , P =.02). Significant decreases in AMH (−1.1±3.1 vs +0.3±0.7 ng/mL, P =.01), insulin (−25.2±51.0 vs −1.2±28.8 pmol/L, P =.02), homoeostasis model of assessment‐estimated insulin resistance (−0.9±2.0 vs −0.1±1.0, P =.02), free androgen index ( FAI ; −0.03±0.09 vs +0.06±0.21, P =.02) and malondialdehyde ( MDA ) levels (−0.5±0.4 vs +0.2±0.3 μmol/L, P <.001), and significant increases in quantitative insulin sensitivity check index (+0.01±0.03 vs −0.004±0.01, P =.02), sex hormone‐binding globulin ( SHBG ; +3.7±8.5 vs −1.5±7.2 nmol/L, P =.01) and nitric oxide ( NO ; +9.0±4.9 vs +0.6±2.3 μmol/L, P <.001) were also seen in the DASH group compared with the control group. Conclusions: Adherence to the DASH diet for 12 weeks among PCOS women had beneficial effects on BMI , AMH , insulin metabolism, SHBG , FAI , NO and MDA levels.
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Four trials mentioning trial registration were considered to have a low risk of reporting bias.
“Four trials mentioning trial registration (37, 38, 41, 42) were considered to have a low risk of reporting bias (Fig. 2).”
From Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome (2020) · cites this paper as [42]
In both studies, the energy-restricted DASH diet group had significant improvement in weight, BMI, and insulin concentrations.
“Significant improvement in weight, BMI, and insulin concentrations were seen in the energy-restricted DASH diet group in both studies [94,95]”
From Moving beyond Weight: A Narrative Review of the Dietary and Lifestyle Management for Reducing Cardiometabolic Risk in Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [95]
Only one study explained allocation concealment.
“with only 1 explaining the allocation concealment (42).”
From Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome (2020) · cites this paper as [42]
Several studies demonstrated that the DASH diet had beneficial effects on markers of insulin resistance, inflammation, oxidative stress, and on hormonal profile (reduced androgens, anti-Müllerian hormone).
“In fact, several studies demonstrated that DASH diet had beneficial effect on markers of IR, inflammation, oxidative stress, and on hormonal profile (reduced androgens, anti-Müllerian hormone) [34–37].”
From Ketogenic Diet as Medical Prescription in Women with Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [37]
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“5) shown in the DASH diet group compared to the control group (Azadi et al., 2016; Foroozanfard et al., 2017).”
BackgroundMethodResultInfluential
- Authors
- Foroozanfard, F., Rafiei, H., Samimi, M., Gilasi, H. R., Gorjizadeh, R., Heidar, Z., & Asemi, Z.
- Affiliations
- Kashan University of Medical Sciences (IR)
- Shahid Beheshti University (IR)
- Corresponding author
- Asemi, Zatollah
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2017-04-11
- Volume
- 87
- Issue
- 1
- Pages
- 51-58
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2595803885
- Cited by
- 75
- References
- 35
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 9 · 2023: 14 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 2 · 2018: 3 · 2017: 2
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Update notices
- expression_of_concern (2024-02-26)
- Open access
- bronze
- doi.org
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- DASH diet, polycystic ovary syndrome, weight loss, anti-Müllerian hormone, insulin resistance, metabolic profile, sex hormone-binding globulin, free androgen index, malondialdehyde, nitric oxide, hypocaloric diet, obesity, insulin sensitivity, oxidative stress, women's health, dietary intervention, BMI reduction, sex hormones
- MeSH terms
- Dietary Approaches To Stop Hypertension, Adult, Female, Humans, Insulin, Malondialdehyde, Nitric Oxide, Polycystic Ovary Syndrome, Sex Hormone-Binding Globulin, Weight Loss, Treatment Outcome, Anti-Mullerian Hormone, Metabolome, Young Adult
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