Selected cytokines and glycodelin A levels in serum and peritoneal fluid in girls with endometriosis
Abstract
Aim: The aim of this study was to determine the role of serum and peritoneal interleukin (IL)‐6, tumor necrosis factor (TNF)‐α and glycodelin A levels as diagnostic markers of endometriosis in adolescent girls. Material and Methods: The study encompassed 50 adolescent girls, aged 13–19 years, after menarche and with chronic pelvic pain who qualified for diagnostic laparoscopy. The patients were allocated into two groups: group I (endometriosis group) consisted of subjects with diagnosed endometriosis (n = 33, 66%) and group II (control group) included those whose laparoscopic examinations revealed no evidence of endometriosis (n = 17, 34%). IL‐6, TNF‐α and glycodelin A concentrations in serum and peritoneal samples were assessed using commercially available human enzyme‐linked immunosorbent assay kits. The value of P < 0.05 was adopted as the level of statistical significance. Results: Compared with the control group, adolescent girls with endometriosis had significantly higher peritoneal fluid levels of: IL‐6 (525.10 ± 1168.53 pg/mL vs 62.96 ± 82.35 pg/mL), TNF‐α (5.79 ± 5.60 pg/mL vs 1.68 ± 1.24 pg/mL) and glycodelin A (94.24 ± 60.97 ng/mL vs 53.52 ± 41.43 ng/mL). Peritoneal IL‐6, TNF‐α and glycodelin A provided a good method of discrimination between subjects with endometriosis and controls. Using cut‐off points for peritoneal fluid IL‐6 (90.00 pg/mL), TNF‐α (3.00 pg/mL) and glycodelin A (60.0 ng/mL), exceptionally high odds ratios (10.2; 14.6; 2.2) were obtained in the prediction of endometriosis in adolescents. Conclusions: At the cut‐off value of 3.00 pg/mL, peritoneal TNF‐α can be a reliable screening marker for the prediction of endometriosis in adolescents, giving a 14.6‐fold higher probability of endometriosis detection in girls with chronic pelvic pain.
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Glycodelin A, TNF-α, and IL-6 showed no different expression in follicular phase serum of adolescent girls with endometriosis (n=33) compared with adolescents without endometriosis (n=17).
“Glycodelin A, a promoter of neovascularization and cell proliferation, was examined in follicular phase serum of adolescent girls with endometriosis (n = 33) aged 13–19 alongside TNF-α and IL-6, but none of these proteins showed a different expression compared with adolescents without endometriosis (n = 17) [46].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [46]
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Update on biomarkers for the detection of endometriosis
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“Glycodelin A, a promoter of neovascularization and cell proliferation, was examined in follicular phase serum of adolescent girls with endometriosis (n = 33) aged 13–19 alongside TNF-α and IL-6, but none of these proteins showed a different expression compared with adolescents without endometriosis (n = 17) [46].”
An integrated multi-tissue approach for endometriosis candidate biomarkers: a systematic review
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- Authors
- Drosdzol‐Cop, A., & Skrzypulec‐Plinta, V.
- Affiliations
- Medical University of Silesia (PL)
- Venue
- Journal of Obstetrics and Gynaecology Research
- Publisher
- Wiley
- Published
- 2012-05-08
- Volume
- 38
- Issue
- 10
- Pages
- 1245-1253
- ISSN
- 1341-8076 (ISSN-L)
- 1447-0756
- OpenAlex
- W1787839452
- Cited by
- 52
- References
- 28
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 7 · 2015: 6 · 2014: 8 · 2013: 3 · 2012: 1
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of obstetrics and gynaecology research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, adolescent girls, interleukin-6, TNF-α, glycodelin-A, serum cytokines, chronic pelvic pain, diagnostic biomarkers, endometriosis screening, laparoscopy, inflammatory markers, cut-off values, diagnostic accuracy, odds ratio, sensitivity and specificity
- MeSH terms
- Glycodelin, Adolescent, Ascitic Fluid, Endometriosis, Female, Glycoproteins, Humans, Poland, Pregnancy Proteins, Sexual Maturation, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Early Diagnosis, Young Adult
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