The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Pharmaceuticals in the aquatic environment: A critical review of the evidence for health effects in fish
Abstract
The authors review the current data on the presence and reported biological effects in fish of some of the most commonly detected pharmaceuticals in the aquatic environment; namely nonsteroidal anti-inflammatory drugs (NSAIDs), fibrates, beta-blockers, selective serotonin reuptake inhibitors (SSRIs), azoles, and antibiotics. Reported biological effects in fish in the laboratory have often been shown to be in accordance with known effects of pharmaceuticals in mammals. Water concentrations at which such effects have been reported, however, are generally, between microg L(-1) and mg L(-1), typically at least 1 order of magnitude higher than concentrations normally found in surface waters (ng L(-1)). There are exceptions to this, however, as for the case of synthetic oestrogens, which can induce biological effects in the low ng L(-1) range. Although generally effect levels for pharmaceuticals are higher than those found in the environment, the risks to wild fish populations have not been thoroughly characterised, and there has been a lack of consideration given to the likely chronic nature of the exposures, or the potential for mixture effects. As global consumption of pharmaceuticals rises, an inevitable consequence is an increased level of contamination of surface and ground waters with these biologically active drugs, and thus in turn a greater potential for adverse effects in aquatic wildlife.
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Cites
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Ecotoxicology of human pharmaceuticals
Fent, K., Weston, A. A., & Caminada, D. (2006) · Aquatic Toxicology · doi:10.1016/j.aquatox.2005.09.009 · Cited by 3,223
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Occurrence of Antibiotics in the Aquatic Environment
Hirsch, R., Ternes, T., Haberer, K., & Kratz, K.-L. (1999) · Science of The Total Environment · doi:10.1016/s0048-9697(98)00337-4 · Cited by 2,140 · cited 4×
“Antibiotics are a wide-ranging group of compounds of which there are several classes with different mechanisms of action� The antibiotics include sulfonamides, penicillins, and tetracyclins, many examples of which have been detected in WWTW effluents and surface waters at ng L−1 to μg L−1 concentrations (Nakata et al�…”
BackgroundInfluentialNash, J. P., Kime, D. E., Van der Ven, L. T. M., Wester, P. W., Brion, F., Maack, G., Stahlschmidt-Allner, P., & Tyler, C. R. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7209 · Cited by 664
Self-citationThe occurrence of selected human pharmaceutical compounds in UK estuaries
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Cited by
Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions?
Boxall, A. B. A., Rudd, M. A., Brooks, B. W., Caldwell, D. J., Choi, K., Hickmann, S., Innes, E., Ostapyk, K., Staveley, J. P., Verslycke, T., et al. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104477 · Cited by 1,363
Medicating the environment: assessing risks of pharmaceuticals to wildlife and ecosystems
Arnold, K. E., Brown, A. R., Ankley, G. T., & Sumpter, J. P. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0569 · Cited by 441
Zhou, S., Di Paolo, C., Wu, X., Shao, Y., Seiler, T.-B., & Hollert, H. (2019) · Environment International · doi:10.1016/j.envint.2019.04.034 · Cited by 360
Environmental Mass Spectrometry: Emerging Contaminants and Current Issues
Richardson, S. D. (2012) · Analytical Chemistry · doi:10.1021/ac202903d · Cited by 323
Environmental Side Effects of Pharmaceutical Cocktails: What We Know and What We Should Know
Vasquez, M. I., Lambrianides, A., Schneider, M., Kümmerer, K., & Fatta-Kassinos, D. (2014) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2014.06.069 · Cited by 295
Metadata
- Authors
- Corcoran, J., Winter, M. J., & Tyler, C. R.
- Venue
- Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 2010-03-15
- Volume
- 40
- Issue
- 4
- Pages
- 287-304
- ISSN
- 0045-6446 (ISSN-L)
- 1040-8444
- 1547-6898
- OpenAlex
- W2126277206
- Cited by
- 563
- References
- 9
- FWCI
- 27.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pharmaceuticals in the aquatic environment: A critical review of the evidence for health effects in fish. https://app.cochat.ai/papers/10.3109/10408440903373590
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- Corcoran, J., Winter, M. J., & Tyler, C. R. (2010). Pharmaceuticals in the aquatic environment: A critical review of the evidence for health effects in fish. Critical Reviews in Toxicology. https://doi.org/10.3109/10408440903373590
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
