Occurrence of Antibiotics in the Aquatic Environment
Abstract
The recent monitoring of drug residues in the aquatic environment has gained much interest as many pharmaceutical compounds can frequently be found in sewage treatment plant (STP) effluents and river water at concentrations up to several microgram/l. This article describes the analysis of various water samples for 18 antibiotic substances, from the classes of macrolid antibiotics, sulfonamides, penicillins and tetracyclines. Samples were preconcentrated via lyophilization and quantified using HPLC-electrospray-tandem-mass spectrometry. The investigated STP effluents and surface water samples showed frequent appearance of an erythromycin degradation product, roxithromycin and sulfamethoxazole with concentrations up to 6 micrograms/l. Neither tetracyclines nor penicillins could be detected at concentration levels above 50 and 20 ng/l, respectively. From the large number of ground water samples that were taken from agricultural areas in Germany, no contamination by antibiotics was detected except for two sites. This indicates that intake from veterinary applications to the aquatic environment is of minor importance.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Occurrence of drugs in German sewage treatment plants and rivers
Ternes, T. A. (1998) · Water Research · doi:10.1016/s0043-1354(98)00099-2 · Cited by 3,433 · see citing works
Occurrence, fate and effects of pharmaceutical substances in the environment- A review
Halling-Sørensen, B., Nors Nielsen, S., Lanzky, P. F., Ingerslev, F., Holten Lützhøft, H. C., & Jørgensen, S. E. (1998) · Chemosphere · doi:10.1016/s0045-6535(97)00354-8 · Cited by 3,285 · see citing works
The fate of pharmaceutical chemicals in the aquatic environment
Richardson, M. L., & Bowron, J. M. (1985) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1985.tb04922.x · Cited by 743 · see citing works
Holm, J. V., Rügge, K., Bjerg, P. L., & Christensen, T. H. (1995) · Environmental Science & Technology · doi:10.1021/es00005a039 · Cited by 407 · see citing works
Hirsch, R., Ternes, T. A., Haberer, K., Mehlich, A., Ballwanz, F., & Kratz, K. L. (1998) · Journal of Chromatography A · doi:10.1016/s0021-9673(98)00335-5 · Cited by 390 · see citing works
Lunestad, B., & Goksøyr, J. (1990) · Diseases of Aquatic Organisms · doi:10.3354/dao009067 · Cited by 182 · see citing works
Ternes, T. A., Hirsch, R., Mueller, J., & Haberer, K. (1998) · Fresenius Journal of Analytical Chemistry · doi:10.1007/s002160051083 · Cited by 151 · see citing works
Nachweis von Arzneimittelrückständen in Kläranlagen und Fliessgewässern
Stumpf, M., Ternes, T. A., Haberer, K., Seel, P., & Baumann, W. (1996) · Vom Wasser · Cited by 115 · see citing works
Migliore, L., Brambilla, G., Cozzolino, S., & Gaudio, L. (1995) · Agriculture Ecosystems & Environment · doi:10.1016/0167-8809(94)00549-t · Cited by 111 · see citing works
Nachweis von natürlichen und synthetischen Östrogenen in Kläranlagen und Fliessgewässern
Stumpf, M., Ternes, T. A., Haberer, K., & Baumann, W. (1996) · Vom Wasser · Cited by 100 · see citing works
Høverstad, T., Carlstedt‐Duke, B., Lingaas, E., Norin, E. L., Saxerholt, H., Steinbakk, M., & Midtvedt, T. (1986) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528608996411 · Cited by 84 · see citing works
Analysis of Organic Micropollutants in Water
(1984) · Springer eBooks · doi:10.1007/978-94-009-6345-0 · Cited by 79 · see citing works
Watts, C. D., Crathorne, B., Fielding, M., & Steel, C. P. (1984) · Springer eBooks · doi:10.1007/978-94-009-6345-0_13 · Cited by 65 · see citing works
Grabow, W. O. K., van Zyl, M., & Prozesky, O. W. (1976) · Water Research · doi:10.1016/0043-1354(76)90010-5 · Cited by 59 · see citing works
The use of chemotherapeutic agents in aquaculture in the Philippines.
Baticados, M. C. L., & Paclibare, J. O. (1992) · SEAFDEC/AQD Repository (Southeast Asian Fisheries Development Center) · Cited by 56 · see citing works
Smith, P. R., & Samuelsen, O. B. (1996) · Aquaculture · doi:10.1016/s0044-8486(96)01318-x · Cited by 54 · see citing works
Antibiotic resistance in coliform and faecal coliform bacteria from natural waters and effluents
Cooke, M. D. (1976) · New Zealand Journal of Marine and Freshwater Research · doi:10.1080/00288330.1976.9515625 · Cited by 46 · see citing works
Bell, R. B. (1978) · Canadian Journal of Microbiology · doi:10.1139/m78-147 · Cited by 37 · see citing works
Toxicity and bioaccumulation of sulphadimethoxine inArtemia (Crustacea, Anostraca)
Migliore, L., Brambilla, G., Grassitellis, A., & Delupis, G. D. D. (1993) · International Journal of Salt Lake Research · doi:10.1007/bf02905906 · Cited by 36 · see citing works
Transformation of chloramphenicol and oxytetracycline in aquaculture pond sediments
Lai, H., Liu, S., & Chien, Y. (1995) · Journal of Environmental Science and Health Part A Environmental Science and Engineering and Toxicology · doi:10.1080/10934529509376311 · Cited by 31 · see citing works
Antibiotic resistance of heterotrophic bacterial flora of two lakes
Alvero, C. C. (1987) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(87)80073-5 · Cited by 29 · see citing works
Macrolide, lincosamide and streptogramin resistance in Campylobacter jejuni/coli
Burridge, R., Warren, C., & Phillips, I. R. (1986) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/17.3.315 · Cited by 20 · see citing works
Antibiotic resistance among pollution indicator bacteria isolated from Al-Khair river, Baghdad
Al‐Ghazali, M. R., Jazrawi, S. F., & Al-Doori, Z. (1988) · Water Research · doi:10.1016/0043-1354(88)90066-8 · Cited by 15 · see citing works
Drug resistance in Detroit River gram-negative bacilli.
Campeau, R. C., Gulli, L. F., & Graves, J. F. (1996) · PubMed · Cited by 10 · see citing works
Antibiotic resistant coliform and faecal coliform bacteria in drinking water
Jazrawi, S. F., Al-Doori, Z., & Haddad, T. A. (1988) · Water Air & Soil Pollution · doi:10.1007/bf00279482 · Cited by 9 · see citing works
Das vorkommen antibiotikaresistenter klebsiellen im abwasser
Stelzer, W., Ziegert, E., & Schneider, E. (1985) · Zentralblatt für Mikrobiologie · doi:10.1016/s0232-4393(85)80042-1 · Cited by 7 · see citing works
Antibiotic resistance and transfer factor (R+) in E. coli isolated from raw sewage.
Misra, D. S., Kumar, A., & Singh, I. P. (1979) · PubMed · Cited by 7 · see citing works
Pathak, S. P., Gautam, A. R., Gaur, A., Gopal, K., & Ray, P. K. (1993) · Journal of Environmental Science and Health Part A Environmental Science and Engineering and Toxicology · doi:10.1080/10934529309375953 · Cited by 4 · see citing works
Wastewater Sludge Disposal: Antibiotic Resistant Bacteria May Pose Health Hazard
Radtke, T. M., & Gist, G. L. (1989) · Digital Commons - East Tennessee State University (East Tennessee State University) · Cited by 4 · see citing works
On the drinking water situation on the Cape Verde Islands (Island of Santiago).
Buchrieser, V., Brosch, R., Buchrieser, C., Miorini, T., & SIXL, W. (1989) · PubMed · Cited by 2 · see citing works
THE INCIDENCE OF ANTIBIOTIC-RESISTANT ESCHERICHIA COLI IN WATER USED ON DAIRY FARMS
Joyce, D. A., LYNE, A. R., & ROBINSON, I. (1984) · Elsevier eBooks · doi:10.1016/b978-0-408-11155-3.50047-3 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 32 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B., & Buxton, H. T. (2002) · Environmental Science & Technology · doi:10.1021/es011055j · Cited by 7,953 · see citing works
Pharmaceuticals and Personal Care Products in the Environment: Agents of Subtle Change?
Daughton, C. G., & Ternes, T. A. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107s6907 · Cited by 4,703 · see citing works
Antibiotics in the aquatic environment – A review – Part I
Kümmerer, K. (2009) · Chemosphere · doi:10.1016/j.chemosphere.2008.11.086 · Cited by 4,485 · see citing works
Zhang, Q.-Q., Ying, G., Pan, C., Liu, Y., & Zhao, J. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b00729 · Cited by 3,861 · see citing works
Luo, Y., Guo, W., Ngo, H. H., Nghiem, L. D., Hai, F. I., Zhang, J., Liang, S., & Wang, X. C. (2014) · Science of The Total Environment · doi:10.1016/j.scitotenv.2013.12.065 · Cited by 3,983 · see citing works
Sarmah, A. K., Meyer, M. T., & Boxall, A. B. A. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.03.026 · Cited by 3,326 · see citing works
Ecotoxicology of human pharmaceuticals
Fent, K., Weston, A. A., & Caminada, D. (2006) · Aquatic Toxicology · doi:10.1016/j.aquatox.2005.09.009 · Cited by 3,223 · see citing works
Heberer, T. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(02)00041-3 · Cited by 2,995 · see citing works
Patel, M., Kumar, R., Kishor, K., Mlsna, T., Pittman, C. U., & Mohan, D. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00299 · Cited by 2,654 · see citing works
Oller, I., Malato, S., & Pérez, J. A. S. (2010) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2010.08.061 · Cited by 2,411 · see citing works
Deborde, M., & von Gunten, U. (2007) · Water Research · doi:10.1016/j.watres.2007.07.025 · Cited by 2,071 · see citing works
Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment
Ebele, A. J., Abou-Elwafa Abdallah, M., & Harrad, S. (2017) · Emerging Contaminants · doi:10.1016/j.emcon.2016.12.004 · Cited by 2,023 · see citing works
Michael, I., Rizzo, L., McArdell, C. S., Manaia, C. M., Merlin, C., Schwartz, T., Dagot, C., & Fatta‐Kassinos, D. (2012) · Water Research · doi:10.1016/j.watres.2012.11.027 · Cited by 2,025 · see citing works
Environmental pollution by antibiotics and by antibiotic resistance determinants
Martínez, J. L. (2009) · Environmental Pollution · doi:10.1016/j.envpol.2009.05.051 · Cited by 1,920 · see citing works
Emerging organic contaminants in groundwater: A review of sources, fate and occurrence
Lapworth, D. J., Baran, N., Stuart, M. E., & Ward, R. S. (2012) · Environmental Pollution · doi:10.1016/j.envpol.2011.12.034 · Cited by 1,913 · see citing works
Hernando, M. D., Mezcúa, M., FERNANDEZALBA, A., & Barceló, . (2005) · Talanta · doi:10.1016/j.talanta.2005.09.037 · Cited by 1,738 · see citing works
Rodríguez‐Mozaz, S., Chamorro, S., Marti, E., Huerta, B., Gros, M., Sànchez-Melsió, A., Borrego, C., Barceló, ., & Balcázar, J. L. (2014) · Water Research · doi:10.1016/j.watres.2014.11.021 · Cited by 1,625 · see citing works
Tetracycline antibiotics in the environment: a review
Daghrir, R., & Drogui, P. (2013) · Environmental Chemistry Letters · doi:10.1007/s10311-013-0404-8 · Cited by 1,605 · see citing works
Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant
Carballa, M., Omil, F., Lema, J. M., Llompart, M., Garcı́a-Jares, C., Rodríguez, I., Gómez, M., & Ternes, T. A. (2004) · Water Research · doi:10.1016/j.watres.2004.03.029 · Cited by 1,557 · see citing works
Degradation and removal methods of antibiotics from aqueous matrices – A review
Homem, V., & Santos, L. (2011) · Journal of Environmental Management · doi:10.1016/j.jenvman.2011.05.023 · Cited by 1,524 · see citing works
Yang, Y., Ok, Y. S., Kim, K.-H., Kwon, E. E., & Tsang, Y. F. (2017) · Science of The Total Environment · doi:10.1016/j.scitotenv.2017.04.102 · Cited by 1,608 · see citing works
Pharmaceuticals as emerging contaminants and their removal from water. A review
Rivera-Utrilla, J., Sánchez-Polo, M., Ferro-García, M. Á., Prados-Joya, G., & Ocampo-Pérez, R. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.07.059 · Cited by 1,486 · see citing works
Occurrence and toxicity of antibiotics in the aquatic environment: A review
Kovalakova, P., Cizmas, L. H., McDonald, T. J., Maršálek, B., Feng, M., & Sharma, V. K. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126351 · Cited by 1,465 · see citing works
Sorption of Veterinary Pharmaceuticals in Soils: A Review
Tolls, J. (2001) · Environmental Science & Technology · doi:10.1021/es0003021 · Cited by 1,390 · see citing works
Veterinary antibiotics in the aquatic and terrestrial environment
Kemper, N. (2007) · Ecological Indicators · doi:10.1016/j.ecolind.2007.06.002 · Cited by 1,368 · see citing works
Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions?
Boxall, A. B. A., Rudd, M. A., Brooks, B. W., Caldwell, D. J., Choi, K., Hickmann, S., Innes, E., Ostapyk, K., Staveley, J. P., Verslycke, T. A., et al. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104477 · Cited by 1,366 · see citing works
Antibiotics in the aquatic environments: A review of the European scenario
Carvalho, I. T., & Santos, L. (2016) · Environment International · doi:10.1016/j.envint.2016.06.025 · Cited by 1,315 · see citing works
Emerging pollutants in wastewater: a review of the literature.
Deblonde, T., Cossu-Leguille, C., & Hartemann, P. (2011) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2011.08.002 · Cited by 1,185 · see citing works
Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment
Andreozzi, R., Marotta, R., & Paxéus, N. (2003) · Chemosphere · doi:10.1016/s0045-6535(02)00769-5 · Cited by 1,314 · see citing works
Antibiotics in the aquatic environment – A review – Part II
Kümmerer, K. (2009) · Chemosphere · doi:10.1016/j.chemosphere.2008.12.006 · Cited by 1,299 · see citing works
Xu, L., Zhang, H., Xiong, P., Zhu, Q., Liao, C., & Jiang, G. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.141975 · Cited by 1,214 · see citing works
Adsorptive removal of antibiotics from water and wastewater: Progress and challenges
Ahmed, M. B., Zhou, J. L., Ngo, H. H., & Guo, W. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.05.130 · Cited by 1,221 · see citing works
The occurrence of antibiotics in an urban watershed: From wastewater to drinking water
Watkinson, A., Murby, E. J., Kolpin, D. W., & Costanzo, S. D. (2009) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2008.11.059 · Cited by 1,200 · see citing works
Watkinson, A., Murby, E. J., & Costanzo, S. D. (2007) · Water Research · doi:10.1016/j.watres.2007.04.005 · Cited by 1,193 · see citing works
Kasprzyk‐Hordern, B., Dinsdale, R. M., & Guwy, A. J. (2008) · Water Research · doi:10.1016/j.watres.2008.04.026 · Cited by 1,150 · see citing works
Human Pharmaceuticals in the Aquatic Environment: A Challenge to Green Chemistry
Khetan, S. K., & Collins, T. J. (2007) · Chemical Reviews · doi:10.1021/cr020441w · Cited by 1,148 · see citing works
Antibiotic pollution in surface fresh waters: Occurrence and effects
Danner, M.-C., Robertson, A. L., Behrends, V., & Reiss, J. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.01.406 · Cited by 1,139 · see citing works
Wellington, E. M. H., Boxall, A. B. A., Cross, P., Feil, E. J., Gaze, W. H., Hawkey, P. M., Johnson-Rollings, A. S., Jones, D. L., Lee, N. M., Otten, W., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70317-1 · Cited by 1,128 · see citing works
Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects
Cleuvers, M. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(03)00068-7 · Cited by 991 · see citing works
Degradation of Aqueous Pharmaceuticals by Ozonation and Advanced Oxidation Processes: A Review
Ikehata, K., Naghashkar, N. J., & El‐Din, M. G. (2006) · Ozone Science and Engineering · doi:10.1080/01919510600985937 · Cited by 969 · see citing works
Occurrence patterns of pharmaceuticals in water and wastewater environments
Nikolaou, A. D., Meriç, S., & Fatta‐Kassinos, D. (2007) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-006-1035-8 · Cited by 954 · see citing works
Kümmerer, K. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh325 · Cited by 940 · see citing works
Hu, X., Zhou, Q., & Luo, Y. (2010) · Environmental Pollution · doi:10.1016/j.envpol.2010.05.023 · Cited by 928 · see citing works
ROBERTS, P., & Thomas, K. V. (2005) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2005.04.031 · Cited by 920 · see citing works
Wang, J., Chu, L., Wojnárovits, L., & Takács, E. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.140997 · Cited by 903 · see citing works
Hamscher, G., Sczesny, S., Höper, H., & Nau, H. (2002) · Analytical Chemistry · doi:10.1021/ac015588m · Cited by 899 · see citing works
Schwartz, T., Kohnen, W., Jansen, B., & Obst, U. (2003) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2003.tb01073.x · Cited by 889 · see citing works
Removal of pharmaceuticals and fragrances in biological wastewater treatment
Joss, A., Keller, E., Alder, A. C., Göbel, A., McArdell, C. S., Ternes, T. A., & Siegrist, H. (2005) · Water Research · doi:10.1016/j.watres.2005.05.031 · Cited by 868 · see citing works
Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators
Singer, A. C., Shaw, H., Rhodes, V., & Hart, A. J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01728 · Cited by 851 · see citing works
Removal of Pharmaceuticals in Sewage Treatment Plants in Italy
Castiglioni, S., Bagnati, R., Fanelli, R., Pomati, F., Calamari, D., & Zuccato, E. (2006) · Environmental Science & Technology · doi:10.1021/es050991m · Cited by 841 · see citing works
Chee‐Sanford, J. C., Mackie, R. I., Koike, S., Krapac, I. G., Lin, Y.-F. F., Yannarell, A. C., Maxwell, S., & Aminov, R. I. (2009) · Journal of Environmental Quality · doi:10.2134/jeq2008.0128 · Cited by 831 · see citing works
Occurrence of Antimicrobials in the Final Effluents of Wastewater Treatment Plants in Canada
Miao, X., Bishay, F., Chen, M., & Metcalfe, C. D. (2004) · Environmental Science & Technology · doi:10.1021/es030653q · Cited by 817 · see citing works
Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA
Karthikeyan, K. G., & Meyer, M. T. (2005) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2005.06.030 · Cited by 810 · see citing works
Clarke, B. O., & Smith, S. R. (2010) · Environment International · doi:10.1016/j.envint.2010.06.004 · Cited by 813 · see citing works
Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China
Zhao, L., Dong, Y., & Wang, H. (2009) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2009.11.014 · Cited by 793 · see citing works
Ji, L., Chen, W., Duan, L., & Zhu, D. (2009) · Environmental Science & Technology · doi:10.1021/es803268b · Cited by 801 · see citing works
Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies
Göbel, A., McArdell, C. S., Joss, A., Siegrist, H., & Giger, W. (2006) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2006.07.039 · Cited by 799 · see citing works
Bendz, D., Paxéus, N., Ginn, T. R., & Loge, F. J. (2005) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2005.03.012 · Cited by 796 · see citing works
González-Pleiter, M., Gonzalo, S., Rodea‐Palomares, I., Leganés, F., Rosal, R., Boltes, K., Marco, E., & Fernández‐Piñas, F. (2013) · Water Research · doi:10.1016/j.watres.2013.01.020 · Cited by 786 · see citing works
Brown, K. D., Kulis, J., Thomson, B. M., Chapman, T. H., & Mawhinney, D. B. (2005) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2005.10.007 · Cited by 786 · see citing works
Global Synthesis and Critical Evaluation of Pharmaceutical Data Sets Collected from River Systems
Hughes, S. R., Kay, P., & Brown, L. E. (2012) · Environmental Science & Technology · doi:10.1021/es3030148 · Cited by 779 · see citing works
Trends in Antibiotic Resistance Genes Occurrence in the Haihe River, China
Luo, Y., Mao, D., Rysz, M. W., Zhou, Q., Zhang, H., Xu, L., & Alvarez, P. J. J. (2010) · Environmental Science & Technology · doi:10.1021/es100233w · Cited by 781 · see citing works
Göbel, A., Thomsen, A., McArdell, C. S., Joss, A., & Giger, W. (2005) · Environmental Science & Technology · doi:10.1021/es048550a · Cited by 760 · see citing works
Gros, M., Petrović, M., & Barceló, . (2006) · Talanta · doi:10.1016/j.talanta.2006.05.024 · Cited by 754 · see citing works
Boreen, A. L., Arnold, W. A., & McNeill, K. (2004) · Environmental Science & Technology · doi:10.1021/es0353053 · Cited by 738 · see citing works
Miège, C., Choubert, J. M., Ribeiro, L., Eusèbe, M., & Coquery, M. (2009) · Environmental Pollution · doi:10.1016/j.envpol.2008.11.045 · Cited by 710 · see citing works
Glassmeyer, S. T., Furlong, E. T., Kolpin, D. W., Cahill, J. D., Zaugg, S. D., Werner, S. L., Meyer, M. T., & Kryak, D. D. (2005) · Environmental Science & Technology · doi:10.1021/es048120k · Cited by 705 · see citing works
Kümmerer, K., Al‐Ahmad, A., & Mersch‐Sundermann, V. (2000) · Chemosphere · doi:10.1016/s0045-6535(99)00439-7 · Cited by 696 · see citing works
Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom
Ashton, D. K., Hilton, M. J., & Thomas, K. V. (2004) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2004.04.062 · Cited by 689 · see citing works
Fate of antibiotics during municipal water recycling treatment processes
Le-Minh, N., Khan, S. J., Drewes, J. E., & Stuetz, R. M. (2010) · Water Research · doi:10.1016/j.watres.2010.06.020 · Cited by 778 · see citing works
Toxic and genotoxic evaluation of six antibiotics on non-target organisms
Isidori, M., Lavorgna, M., Nardelli, A., Pascarella, L., & Parrella, A. (2005) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2004.11.017 · Cited by 680 · see citing works
Antibiotics in the aquatic environments: A review of lakes, China
Liu, X., Lu, S., Guo, W., Xi, B., & Wang, W. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.01.271 · Cited by 668 · see citing works
Antibiotic Uptake by Plants from Soil Fertilized with Animal Manure
Kumar, K., Gupta, S. C., Baidoo, S. K., Chander, Y., & Rosen, C. J. (2005) · Journal of Environmental Quality · doi:10.2134/jeq2005.0026 · Cited by 660 · see citing works
Antibiotic resistance genes identified in wastewater treatment plant systems – A review
Pazda, M., Kumirska, J., Stepnowski, P., & Mulkiewicz, E. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134023 · Cited by 654 · see citing works
Martínez‐Carballo, E., González‐Barreiro, C., Scharf, S., & Gans, O. (2007) · Environmental Pollution · doi:10.1016/j.envpol.2006.11.035 · Cited by 647 · see citing works
Veterinary Medicines in the Environment
Boxall, A. B. A., Fogg, L. A., Blackwell, P. A., Blackwell, P., Kay, P., Pemberton, E., & Croxford, A. E. (2004) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/0-387-21729-0_1 · Cited by 639 · see citing works
Removal of Endocrine-Disrupting Chemicals in Activated Sludge Treatment Works
Johnson, A. C., & Sumpter, J. P. (2001) · Environmental Science & Technology · doi:10.1021/es010171j · Cited by 634 · see citing works
Xu, W., Zhang, G., Li, X. D., Zou, S., Li, P., Hu, Z., & Li, J. (2007) · Water Research · doi:10.1016/j.watres.2007.06.023 · Cited by 629 · see citing works
Uptake of Veterinary Medicines from Soils into Plants
Boxall, A. B. A., Johnson, P., Smith, E. J., Sinclair, C. J., Stutt, E., & Levy, L. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf053041t · Cited by 626 · see citing works
Halling‐Sørensen, B., Sengeløv, G., & Tjørnelund, J. (2002) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-001-0017-2 · Cited by 626 · see citing works
Petrović, M., Hernando, M. D., Díaz‐Cruz, M. S., & Barceló, . (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.10.110 · Cited by 620 · see citing works
Antibiotic Use in Agriculture and Its Impact on the Terrestrial Environment
Kumar, K., Gupta, S. C., Chander, Y., & Singh, A. K. (2005) · Advances in agronomy · doi:10.1016/s0065-2113(05)87001-4 · Cited by 617 · see citing works
Ecosystem response to antibiotics entering the aquatic environment
Costanzo, S. D., Murby, J., & Bates, J. R. (2004) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2004.10.038 · Cited by 593 · see citing works
Lindberg, R. H., Wennberg, P., Johansson, M. I., Tysklind, M., & Andersson, B. A. V. (2005) · Environmental Science & Technology · doi:10.1021/es048143z · Cited by 586 · see citing works
Promoting resistance by the emission of antibiotics from hospitals and households into effluent
Kümmerer, K., & Henninger, A. (2003) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2003.00739.x · Cited by 582 · see citing works
The environmental side effects of medication
Boxall, A. B. A. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400307 · Cited by 575 · see citing works
Εvgenidou, Ε., Konstantinou, I., & Lambropoulou, D. A. (2014) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2014.10.021 · Cited by 565 · see citing works
Corcoran, J., Winter, M. J., & Tyler, C. R. (2010) · Critical Reviews in Toxicology · doi:10.3109/10408440903373590 · Cited by 565 · see citing works
Ferrari, B. J. D., Mons, R., Vollat, B., Fraysse, B., Paxēaus, N., Giudice, R. L., Pollio, A., & Garric, J. (2004) · Environmental Toxicology and Chemistry · doi:10.1897/03-246 · Cited by 562 · see citing works
Household Disposal of Pharmaceuticals as a Pathway for Aquatic Contamination in the United Kingdom
Bound, J. P., & Voulvoulis, N. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8315 · Cited by 554 · see citing works
Antibiotics in soil and water in China–a systematic review and source analysis
Lyu, J., Yang, L., Zhang, L. H., Ye, B., & Wang, L. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115147 · Cited by 552 · see citing works
A review of the occurrence of pharmaceuticals and personal care products in Indian water bodies
Balakrishna, K., Rath, A., Praveenkumarreddy, Y., Guruge, K. S., & Subedi, B. (2016) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2016.11.014 · Cited by 545 · see citing works
Determination of Antibiotic Residues in Manure, Soil, and Surface Waters
Christian, T., Schneider, R. J., Färber, H. A., Skutlarek, D., Meyer, M. T., & Goldbach, H. E. (2003) · Acta hydrochimica et hydrobiologica · doi:10.1002/aheh.200390014 · Cited by 538 · see citing works
Xu, W., Zhang, G., Zou, S., Li, X. D., & Liu, Y. (2006) · Environmental Pollution · doi:10.1016/j.envpol.2006.05.038 · Cited by 537 · see citing works
Kim, S. C., & Carlson, K. (2006) · Environmental Science & Technology · doi:10.1021/es060737+ · Cited by 535 · see citing works
Excretion and ecotoxicity of pharmaceutical and personal care products in the environment
Jjemba, P. K. (2005) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2004.11.011 · Cited by 526 · see citing works
McClellan, K., & Halden, R. U. (2010) · Water Research · doi:10.1016/j.watres.2009.12.032 · Cited by 526 · see citing works
Wastewater Reuse in Agriculture: A Review about Its Limitations and Benefits
Jaramillo-Llorente, M. F., & Tarquino, I. R. (2017) · Sustainability · doi:10.3390/su9101734 · Cited by 523 · see citing works
Len Ritter, K. S. (2002) · Journal of Toxicology and Environmental Health · doi:10.1080/152873902753338572 · Cited by 522 · see citing works
Household hazardous waste in municipal landfills: contaminants in leachate
Slack, R. J., Gronow, J. R., & Voulvoulis, N. (2004) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2004.07.002 · Cited by 519 · see citing works
- Authors
- Hirsch, R., Ternes, T., Haberer, K., & Kratz, K.-L.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 225
- Issue
- 1-2
- Pages
- 109-118
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W2029593210
- Cited by
- 2,140
- References
- 32
- Citations by year
- 2026: 19 · 2025: 37 · 2024: 48 · 2023: 54 · 2022: 74 · 2021: 83 · 2020: 100 · 2019: 93 · 2018: 117 · 2017: 103 · 2016: 102 · 2015: 112 · 2014: 121 · 2013: 113 · 2012: 124
- FWCI
- 25.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Science of The Total Environment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Ministry of Environment
- Topics
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Keywords
- antibiotic residues, aquatic environment, sewage treatment plant effluent, surface water, groundwater contamination, sulfonamides, penicillin, tetracycline, roxithromycin, sulfamethoxazole, veterinary antibiotic use, agricultural land
- MeSH terms
- Agriculture, Animals, Anti-Bacterial Agents, Bacteria, Biodegradation, Environmental, Drug Resistance, Microbial, Erythromycin, Germany, Humans, Sewage, Water Pollutants, Chemical
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review