The DOI matches its Crossref record; 122 of the 123 references it cites were found in a registry or an index.
Personal care products and endocrine disruption: A critical review of the literature
Abstract
This article reviews laboratory and epidemiological research into the endocrine disruptive effects of components of personal care products, namely, phthalate esters, parabens, ultraviolet (UV) filters, polycyclic musks, and antimicrobials. High doses of phthalates in utero can produce “phthalate syndrome,” demasculinizing effects in male rat offspring due to impaired testosterone production by fetal testes. However, evidence linking phthalate exposure to similar effects in humans appears inconclusive. Furthermore, phthalate exposure derived from personal care products is within safe limits and its principal bioavailable phthalate, diethyl phthalate (DEP), does not produce “phthalate syndrome.” Parabens exhibit very weak estrogen activity in vitro and in vivo, but evidence of paraben-induced developmental and reproductive toxicity in vivo lacks consistency and physiological coherence. Evidence attempting to link paraben exposure with human breast cancer is nonexistent. Select UV filters at high doses produce estrogenic, antithyroid, and other effects in rats in vivo. Again, no evidence links UV filter exposure to endocrine disruptive effects in humans. Some polycyclic musks weakly bind to estrogen, androgen, or progestin receptors and exhibit primarily antagonistic activity in vitro, which for the most part, has yet to be confirmed in vivo in mammals. The antimicrobials triclocarban and triclosan evoke weak responses mediated by aryl hydrocarbon, estrogen, and androgen receptors in vitro, which require confirmation in vivo. Preliminary observations suggest a novel interaction between triclocarban and testosterone. In conclusion, although select constituents exhibit interactions with the endocrine system in the laboratory, the evidence linking personal care products to endocrine disruptive effects in humans is for the most part lacking.
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In the citing paper
“Witorsch et al. (2010) referred the negative impact of some classes of compounds, including UV filters that crossed the skin layers; nevertheless, this study highlighted that serum and reproductive hormones levels were not affected by this exposure [70].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [70]
In the citing paper
“Witorsch et al. (2010) referred the negative impact of some classes of compounds, including UV filters that crossed the skin layers; nevertheless, this study highlighted that serum and reproductive hormones levels were not affected by this exposure [70].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [70]
In the citing paper
“Several studies have concluded that there is no causal relationship between parabens and breast cancer13”
From Knowledge and Behavior Regarding Cosmetics in Koreans Visiting Dermatology Clinics (2017) · cites this paper as [13]
Citations
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Cited by
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Krutmann, J., Bouloc, A., Sore, G., Bernard, B. A., & Passeron, T. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2016.09.015 · Cited by 768
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Metadata
- Authors
- Witorsch, R. J., & Thomas, J. A.
- Affiliations
- Virginia Commonwealth University (US)
- Indiana University School of Medicine (US)
- Corresponding author
- Witorsch, Raphael J.
- ORCID
- Thomas, John A.
- Venue
- Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 2010-10-11
- Volume
- 40
- Issue
- sup3
- Pages
- 1-30
- ISSN
- 0045-6446 (ISSN-L)
- 1040-8444
- 1547-6898
- OpenAlex
- W2154786792
- Cited by
- 334
- References
- 123
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 12 · 2023: 13 · 2022: 21 · 2021: 19 · 2020: 29 · 2019: 24 · 2018: 38 · 2017: 18 · 2016: 24 · 2015: 25 · 2014: 26 · 2013: 21 · 2012: 19
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- endocrine disruption, personal care products, phthalates, parabens, UV filters, polycyclic musks, antimicrobial agents, triclocarban, triclosan, diethyl phthalate, breast cancer, reproductive toxicity, developmental toxicity, estrogenic activity, androgen receptor, aryl hydrocarbon receptor, progestin receptor, human exposure
- MeSH terms
- Animals, Breast Neoplasms, Carbanilides, Cosmetics, Estrogens, Female, Humans, Male, Parabens, Phthalic Acids, Receptors, Androgen, Triclosan, Ultraviolet Rays, Carcinoma, Ductal, Breast, Receptors, Aryl Hydrocarbon, Rats, Endocrine Disruptors
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