Cited by 334Effects and risks of endocrine disrupting chemicalsPesticide Exposure and ToxicityPharmaceutical and Antibiotic Environmental Impacts

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Personal care products and endocrine disruption: A critical review of the literature

Witorsch, Raphael J., Thomas, John A.·2010·Critical Reviews in Toxicology

DOI 10.3109/10408444.2010.515563

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Abstract

This article reviews laboratory and epidemiological research into the endocrine disruptive effects of components of personal care products, namely, phthalate esters, parabens, ultraviolet (UV) filters, polycyclic musks, and antimicrobials. High doses of phthalates in utero can produce “phthalate syndrome,” demasculinizing effects in male rat offspring due to impaired testosterone production by fetal testes. However, evidence linking phthalate exposure to similar effects in humans appears inconclusive. Furthermore, phthalate exposure derived from personal care products is within safe limits and its principal bioavailable phthalate, diethyl phthalate (DEP), does not produce “phthalate syndrome.” Parabens exhibit very weak estrogen activity in vitro and in vivo, but evidence of paraben-induced developmental and reproductive toxicity in vivo lacks consistency and physiological coherence. Evidence attempting to link paraben exposure with human breast cancer is nonexistent. Select UV filters at high doses produce estrogenic, antithyroid, and other effects in rats in vivo. Again, no evidence links UV filter exposure to endocrine disruptive effects in humans. Some polycyclic musks weakly bind to estrogen, androgen, or progestin receptors and exhibit primarily antagonistic activity in vitro, which for the most part, has yet to be confirmed in vivo in mammals. The antimicrobials triclocarban and triclosan evoke weak responses mediated by aryl hydrocarbon, estrogen, and androgen receptors in vitro, which require confirmation in vivo. Preliminary observations suggest a novel interaction between triclocarban and testosterone. In conclusion, although select constituents exhibit interactions with the endocrine system in the laboratory, the evidence linking personal care products to endocrine disruptive effects in humans is for the most part lacking.

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Authors: Witorsch, R. J., & Thomas, J. A.
Affiliations: Virginia Commonwealth University (US)
Indiana University School of Medicine (US)
Corresponding author: Witorsch, Raphael J.
ORCID: Thomas, John A.
Venue: Critical Reviews in Toxicology
Publisher: Informa UK Limited
Published: 2010-10-11
Volume: 40
Issue: sup3
Pages: 1-30
ISSN: 0045-6446 (ISSN-L)
1040-8444
1547-6898
DOI: 10.3109/10408444.2010.515563
OpenAlex: W2154786792
Cited by: 334
References: 123
Citations by year: 2026: 10 · 2025: 17 · 2024: 12 · 2023: 13 · 2022: 21 · 2021: 19 · 2020: 29 · 2019: 24 · 2018: 38 · 2017: 18 · 2016: 24 · 2015: 25 · 2014: 26 · 2013: 21 · 2012: 19
FWCI: 1.87
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Toxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Keywords: endocrine disruption, personal care products, phthalates, parabens, UV filters, polycyclic musks, antimicrobial agents, triclocarban, triclosan, diethyl phthalate, breast cancer, reproductive toxicity, developmental toxicity, estrogenic activity, androgen receptor, aryl hydrocarbon receptor, progestin receptor, human exposure
MeSH terms: Animals, Breast Neoplasms, Carbanilides, Cosmetics, Estrogens, Female, Humans, Male, Parabens, Phthalic Acids, Receptors, Androgen, Triclosan, Ultraviolet Rays, Carcinoma, Ductal, Breast, Receptors, Aryl Hydrocarbon, Rats, Endocrine Disruptors

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Personal care products and endocrine disruption: A critical review of the literature

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