The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Toxicology of Molecular Oxygen
Abstract
Molecular oxygen, itself not very reactive, can be converted by photosensitization to electronically excited singlet states, and by partial reduction to the superoxide and hydroxyl free radicals and to hydrogen peroxide. The very considerable toxicity of oxygen, which is due primarily to the properties of these derivatives, is ordinarily overlooked because aerobes have evolved an elaborate system of defenses which is reasonably adequate under ambient conditions. This toxicity becomes all too apparent when these defenses are overwhelmed at elevated pO2 or through the action of compounds which increase the conversion of oxygen to its more reactive derivatives. We will here consider the threat posed by oxygen and the defenses which make aerobic life possible.
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Cites
LXXIII.—Oxidation of tartaric acid in presence of iron
Fenton, H. J. H. (1894) · J. Chem. Soc., Trans. · doi:10.1039/ct8946500899 · Cited by 3,179
Harman, D. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7124 · Cited by 1,915
Oxygen poisoning and x-irradiation: a mechanism in common
Gerschman, R., Gilbert, D. L., Nye, S. W., Dwyer, P., & Fenn, W. O. (1954) · Science · doi:10.1126/science.119.3097.623 · Cited by 961
Weisiger, R. A., & Fridovich, I. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43969-0 · Cited by 895
Self-citationCadenas, E., Boveris, A., Ragan, C. I., & Stoppani, A. O. M. (1977) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(77)90035-2 · Cited by 855
Electrostatic interactions in the reaction mechanism of bovine erythrocyte superoxide dismutase
Cudd, A., & Fridovich, I. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33779-7 · Cited by 211
Self-citationGreenstock, C. L., & Miller, R. W. (1975) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(75)90184-x · Cited by 157
Cited by
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
Halliwell, B., & Gutteridge, J. M. C. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90305-x · Cited by 2,038
Oxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856
Self-citationThe chemical biology of nitric oxide: Implications in cellular signaling
Thomas, D. D., Ridnour, L. A., Isenberg, J. S., Flores-Santana, W., Switzer, C. H., Donzelli, S., Hussain, P., Vecoli, C., Paolocci, N., Ambs, S., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.020 · Cited by 975
The importance of free radicals and catalytic metal ions in human diseases.
Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941
Metadata
- Authors
- Diguiseppi, J., Fridovich, I., & McCord, J. M.
- Venue
- CRC Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 1984-01
- Volume
- 12
- Issue
- 4
- Pages
- 315-342
- ISSN
- 0045-6446 (ISSN-L)
- OpenAlex
- W2084871959
- Cited by
- 205
- References
- 7
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Diguiseppi, J., Fridovich, I., & McCord, J. M. (1984). The Toxicology of Molecular Oxygen. CRC Critical Reviews in Toxicology. https://doi.org/10.3109/10408448409044213
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
