Cited by 242Toxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicalsPesticide Exposure and Toxicity

Epidemiological and Laboratory Evidence of PCB-lnduced Neurotoxicity

Seegal, Richard F.·1996·Critical Reviews in Toxicology

Abstract

The purpose of this review is to provide a selective, but critical, assessment of important findings derived from both epidemiological and laboratory studies suggesting that: (1) exposure to polychlorinated biphenyls (PCBs) and related halogenated aromatic hydrocarbons induces significant neurological and behavioral dysfunctions in humans and laboratory animals, particularly following exposure during gestation and lactation; (2) the neurochemical actions of PCBs depend on their structure and the developmental status of the animal at the time of exposure; and (3) the mechanisms responsible for these changes may involve alterations in basic cellular signaling processes and endocrine function that influence the synthesis and activity of important central nervous system neurotransmitters, the organization of the developing brain, and the behavioral responses to these environmental contaminants.

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Registry

Crossref · 10.3109/10408449609037481

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128 of 128 references verified0 citation errors · 0 not checkable

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  • The weight of evidence from epidemiological studies supports a negative association between developmental exposure to PCBs and neuropsychological function in infancy and childhood.

    “The weight of evidence from epidemiological studies supports a negative association between developmental exposure to PCBs and neuropsychological function in infancy and childhood [ 56 , 95–99 ].”

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Authors
Seegal, R. F.
Affiliations
New York State Department of Health (US)
Corresponding author
Seegal, Richard F.
Venue
Critical Reviews in Toxicology
Published
1996-01
Volume
26
Issue
6
Pages
709-737
ISSN
  • 0045-6446 (ISSN-L)
  • 1040-8444
  • 1547-6898
OpenAlex
W1975003944
Cited by
242
References
130
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 8
FWCI
2.84
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
Keywords
polychlorinated biphenyls, neurotoxicity, developmental neurotoxicity, prenatal exposure, lactational exposure, halogenated aromatic hydrocarbons, brain development, neurotransmitter synthesis, endocrine disruption, signal transduction, behavioral dysfunction, structure-activity relationship
MeSH terms
Adult, Animals, Humans, Infant, Nervous System Diseases, Polychlorinated Biphenyls

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