The DOI matches its Crossref record; 208 of the 208 references it cites were found in a registry or an index.
Metabolism as an integral cog in the mammalian circadian clockwork
Open accessAbstract
Circadian rhythms are an integral part of life. These rhythms are apparent in virtually all biological processes studies to date, ranging from the individual cell (e.g. DNA synthesis) to the whole organism (e.g. behaviors such as physical activity). Oscillations in metabolism have been characterized extensively in various organisms, including mammals. These metabolic rhythms often parallel behaviors such as sleep/wake and fasting/feeding cycles that occur on a daily basis. What has become increasingly clear over the past several decades is that many metabolic oscillations are driven by cell-autonomous circadian clocks, which orchestrate metabolic processes in a temporally appropriate manner. During the process of identifying the mechanisms by which clocks influence metabolism, molecular-based studies have revealed that metabolism should be considered an integral circadian clock component. The implications of such an interrelationship include the establishment of a vicious cycle during cardiometabolic disease states, wherein metabolism-induced perturbations in the circadian clock exacerbate metabolic dysfunction. The purpose of this review is therefore to highlight recent insights gained regarding links between cell-autonomous circadian clocks and metabolism and the implications of clock dysfunction in the pathogenesis of cardiometabolic diseases.
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Cited by
Sorted by citations
Timing of food intake: identifying contributing factors to design effective interventions
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Meal timing and its role in obesity and associated diseases
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Background
Metadata
- Authors
- Gamble, K. L., & Young, M. E.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Young, Martin E.
- Venue
- Critical Reviews in Biochemistry and Molecular Biology
- Publisher
- Informa UK Limited
- Published
- 2013-04-17
- Volume
- 48
- Issue
- 4
- Pages
- 317-331
- ISSN
- 0045-6411 (ISSN-L)
- 1040-9238
- 1549-7798
- PMC
- PMC3862897
- OpenAlex
- W2007270297
- Cited by
- 18
- References
- 208
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000165)
- Center for Clinical and Translational Science, University of Alabama at Birmingham
- National Heart, Lung, and Blood Institute (HL-074259, HL‑106199, R21HL106199, R21HL107709, HL-107709, R01HL074259)
- National Institute of General Medical Sciences (GM086683, R00GM086683, K99GM086683)
- National Institute of Neurological Disorders and Stroke (R01NS082413, NS082413)
- National Center for Research Resources
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian clock, metabolic rhythms, metabolism, cardiometabolic disease, sleep-wake cycle, circadian metabolism
- MeSH terms
- Animals, Circadian Rhythm, Energy Metabolism, Homeostasis, Humans, Mammals
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